ENSMUSG00000033220


Mus musculus

Features
Gene ID: ENSMUSG00000033220
  
Biological name :Rac2
  
Synonyms : Q05144 / Rac2 / Ras-related C3 botulinum toxin substrate 2
  
Possible biological names infered from orthology : P15153 / Rac family small GTPase 2
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: E1
Gene start: 78559167
Gene end: 78572783
  
Corresponding Affymetrix probe sets: 10430372 (MoGene1.0st)   1417620_at (Mouse Genome 430 2.0 Array)   1440208_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000036384
Ensembl peptide - ENSMUSP00000154826
Ensembl peptide - ENSMUSP00000155090
NCBI entrez gene - 19354     See in Manteia.
MGI - MGI:97846
RefSeq - NM_009008
RefSeq Peptide - NP_033034
swissprot - Q05144
Ensembl - ENSMUSG00000033220
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rac2ENSDARG00000038010Danio rerio
 RAC2ENSGALG00000012456Gallus gallus
 RAC2ENSG00000128340Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*ENSMUSG0000000184792
Rac3 / P60764 / RAS-related C3 botulinum substrate 3 / P60763* / Rac family small GTPase 3*ENSMUSG0000001801288
Rhog / P84096 / ras homolog family member G / P84095*ENSMUSG0000007398271
Cdc42 / P60766 / Cell division control ENSMUSG0000000669969
Rhoq / Q8R527 / Rho-related GTP-binding protein RhoQ / P17081* / ras homolog family member Q*ENSMUSG0000002414359
Rhoj / Q9ER71 / ras homolog family member J / Q9H4E5*ENSMUSG0000004676858
Rhou / Q9EQT3 / Rho-related GTP-binding protein RhoU / Q7L0Q8* / ras homolog family member U*ENSMUSG0000003996054
Rhov / Q8VDU1 / Rho-related GTP-binding protein RhoV / Q96L33* / ras homolog family member V*ENSMUSG0000003422651
Q9DAK3 / Rhobtb1 / Rho-related BTB domain-containing protein 1 / O94844* / Rho related BTB domain containing 1*ENSMUSG0000001994441
Q91V93 / Rhobtb2 / Rho-related BTB domain-containing protein 2 / Q9BYZ6* / Rho related BTB domain containing 2*ENSMUSG0000002207541


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR003578  Small GTPase superfamily, Rho type
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006935 chemotaxis IDA
 biological_processGO:0007015 actin filament organization IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IGI
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0010592 positive regulation of lamellipodium assembly IEA
 biological_processGO:0010810 regulation of cell-substrate adhesion IEA
 biological_processGO:0030031 cell projection assembly IDA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0042129 regulation of T cell proliferation IMP
 biological_processGO:0043304 regulation of mast cell degranulation IMP
 biological_processGO:0045453 bone resorption IEA
 biological_processGO:0045859 regulation of protein kinase activity IEA
 biological_processGO:0060263 regulation of respiratory burst IEA
 biological_processGO:0060753 regulation of mast cell chemotaxis IMP
 biological_processGO:0071593 lymphocyte aggregation IEA
 biological_processGO:0090023 positive regulation of neutrophil chemotaxis IEA
 biological_processGO:1902622 regulation of neutrophil migration IEA
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005635 nuclear envelope IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005884 actin filament IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0030027 lamellipodium IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019887 protein kinase regulator activity IMP


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
Rho GTPase cycle
PCP/CE pathway
G alpha (12/13) signalling events
RHO GTPases Activate NADPH Oxidases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gbx2tm1.1(cre/ERT2)Jyhl/Gbx2tm1Mrt,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gbx2tm1.1(cre/ERT2)Jyhl/Gbx2tm1Mrt,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

Allelic Composition: Rac2m3Btlr/Rac2m3Btlr
Genetic Background: C57BL/6J-Rac2m3Btlr

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gbx2tm1.1(cre/ERT2)Jyhl/Gbx2tm1Mrt,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gbx2tm1.1(cre/ERT2)Jyhl/Gbx2tm1Mrt,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Rac2m3Btlr/Rac2m3Btlr
Genetic Background: C57BL/6J-Rac2m3Btlr

Allelic Composition: Rac2m3Btlr/Rac2+
Genetic Background: C57BL/6J-Rac2m3Btlr

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rac1tm1Tyb/Rac1tm1Tyb,Rac2tm1Mddw/Rac2tm1Mddw
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ankfy1Gt(RRE069)Byg/Ankfy1Gt(RRE069)Byg
Genetic Background: C.129P2(B6)-Ankfy1Gt(RRE069)Byg

Allelic Composition: Rac2M4Btlr/Rac2+
Genetic Background: C57BL/6J-Rac2M4Btlr

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rab27am2Btlr/Rab27am2Btlr
Genetic Background: C57BL/6J-Rab27am2Btlr

Allelic Composition: Rac2m1Btlr/Rac2+
Genetic Background: C57BL/6J-Rac2m1Btlr

Allelic Composition: Rac2m3Btlr/Rac2m3Btlr
Genetic Background: C57BL/6J-Rac2m3Btlr

Allelic Composition: Rac2M4Btlr/Rac2M4Btlr
Genetic Background: C57BL/6J-Rac2M4Btlr

Allelic Composition: Rac2M4Btlr/Rac2+
Genetic Background: C57BL/6J-Rac2M4Btlr

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Rac2tm1Mddw/Rac2tm1Mddw
Genetic Background: involves: 129S/SvEv

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gbx2tm1.1(cre/ERT2)Jyhl/Gbx2tm1Mrt,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gbx2tm1.1(cre/ERT2)Jyhl/Gbx2tm1Mrt,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

Allelic Composition: Rac2tm1Mddw/Rac2tm1Mddw
Genetic Background: involves: 129S/SvEv

Allelic Composition: Rac2tm1Mddw/Rac2tm1Mddw
Genetic Background: B6.129S-Rac2tm1Mddw

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ankfy1Gt(RRE069)Byg/Ankfy1Gt(RRE069)Byg
Genetic Background: C.129P2(B6)-Ankfy1Gt(RRE069)Byg

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rac2M4Btlr/Rac2+
Genetic Background: C57BL/6J-Rac2M4Btlr

 MP:0002908 delayed wound healing "longer time requirement for the ability to self-repair and close wounds than normal" [J:63037]
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Allelic Composition: Rac2tm1Mddw/Rac2tm1Mddw
Genetic Background: involves: 129S/SvEv

 MP:0004977 increased B-1 B cell number "greater number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rac2m3Btlr/Rac2+
Genetic Background: C57BL/6J-Rac2m3Btlr

 MP:0004978 decreased B-1 B cell number "reduced number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rac1tm1Tyb/Rac1tm1Tyb,Rac2tm1Mddw/Rac2tm1Mddw
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6

Allelic Composition: Rac2M2Btlr/Rac2M2Btlr
Genetic Background: C57BL/6J-Rac2M2Btlr

Allelic Composition: Rac2M2Btlr/Rac2+
Genetic Background: C57BL/6J-Rac2M2Btlr

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rac1tm1Tyb/Rac1tm1Tyb,Rac2tm1Mddw/Rac2tm1Mddw
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6

Allelic Composition: Rac2m3Btlr/Rac2m3Btlr
Genetic Background: C57BL/6J-Rac2m3Btlr

 MP:0005023 abnormal wound healing "aberrant process of repair of trauma to any tissues of the body, especially that caused by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rac2tm1Mddw/Rac2tm1Mddw
Genetic Background: involves: 129S/SvEv

 MP:0005070 defective NK cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]
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Allelic Composition: Rac2M4Btlr/Rac2M4Btlr
Genetic Background: C57BL/6J-Rac2M4Btlr

Allelic Composition: Rac2M4Btlr/Rac2+
Genetic Background: C57BL/6J-Rac2M4Btlr

 MP:0005078 abnormal cytotoxic T cell physiology "impaired function of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rac2M4Btlr/Rac2M4Btlr
Genetic Background: C57BL/6J-Rac2M4Btlr

Allelic Composition: Rac2M4Btlr/Rac2+
Genetic Background: C57BL/6J-Rac2M4Btlr

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Gbx2tm1.1(cre/ERT2)Jyhl/Gbx2tm1Mrt,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

Allelic Composition: Rac2tm1Mddw/Rac2tm1Mddw,Tg(TcrAND)53Hed/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
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Allelic Composition: Rac2tm1Mddw/Rac2tm1Mddw
Genetic Background: involves: 129S/SvEv

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rac2M4Btlr/Rac2M4Btlr
Genetic Background: C57BL/6J-Rac2M4Btlr

Allelic Composition: Rac2M4Btlr/Rac2+
Genetic Background: C57BL/6J-Rac2M4Btlr

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rac2M4Btlr/Rac2M4Btlr
Genetic Background: C57BL/6J-Rac2M4Btlr

Allelic Composition: Rac2M4Btlr/Rac2+
Genetic Background: C57BL/6J-Rac2M4Btlr

Allelic Composition: Rac2M5Btlr/Rac2M5Btlr
Genetic Background: C57BL/6J-Rac2M5Btlr

Allelic Composition: Rac2M5Btlr/Rac2+
Genetic Background: C57BL/6J-Rac2M5Btlr

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rac2M4Btlr/Rac2M4Btlr
Genetic Background: C57BL/6J-Rac2M4Btlr

Allelic Composition: Rac2M4Btlr/Rac2+
Genetic Background: C57BL/6J-Rac2M4Btlr

 MP:0008111 abnormal granulocyte differentiaton "atypical production of or inability to produce leukocytes that have abundant granules in the cytoplasm, including basophils, neutrophils, and eosinophils" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gbx2tm1.1(cre/ERT2)Jyhl/Gbx2tm1Mrt,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0008168 decreased B-1a cell number "reduced number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
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Allelic Composition: Rac2M2Btlr/Rac2M2Btlr
Genetic Background: C57BL/6J-Rac2M2Btlr

Allelic Composition: Rac2M2Btlr/Rac2+
Genetic Background: C57BL/6J-Rac2M2Btlr

Allelic Composition: Rac2m3Btlr/Rac2m3Btlr
Genetic Background: C57BL/6J-Rac2m3Btlr

Allelic Composition: Rac2m3Btlr/Rac2+
Genetic Background: C57BL/6J-Rac2m3Btlr

Allelic Composition: Rac2M5Btlr/Rac2M5Btlr
Genetic Background: C57BL/6J-Rac2M5Btlr

 MP:0008169 increased B-1b cell number "greater number of the B-1 B cell subset not bearing the CD5 surface marker, but having other phenotypic attributes of a B-1 B cell" [CL:0000821, PMID:11861604]
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Allelic Composition: Rac2M2Btlr/Rac2M2Btlr
Genetic Background: C57BL/6J-Rac2M2Btlr

Allelic Composition: Rac2M2Btlr/Rac2+
Genetic Background: C57BL/6J-Rac2M2Btlr

Allelic Composition: Rac2m3Btlr/Rac2m3Btlr
Genetic Background: C57BL/6J-Rac2m3Btlr

Allelic Composition: Rac2M5Btlr/Rac2M5Btlr
Genetic Background: C57BL/6J-Rac2M5Btlr

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rac1tm1Tyb/Rac1tm1Tyb,Rac2tm1Mddw/Rac2tm1Mddw
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rac1tm1Tyb/Rac1tm1Tyb,Rac2tm1Mddw/Rac2tm1Mddw
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6

 MP:0008190 decreased transitional stage B cell number "reduced number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rac1tm1Tyb/Rac1tm1Tyb,Rac2tm1Mddw/Rac2tm1Mddw
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6

 MP:0008600 decreased circulating interleukin-2 level "reduction in the amount in the blood of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Rac2tm1Mddw/Rac2tm1Mddw,Tg(TcrAND)53Hed/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0008720 impaired neutrophil migration "defect in the ability of neutrophils to move along a chemotactic gradient" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gbx2tm1.1(cre/ERT2)Jyhl/Gbx2tm1Mrt,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gbx2tm1.1(cre/ERT2)Jyhl/Gbx2tm1Mrt,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL

 MP:0010841 increased central memory CD4-positive, alpha-beta T cell number "increased number of CD4-positive, alpha-beta memory T cells with the phenotype CCR7-positive, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000904, GO_REF:0000031, GOC:add, GOC:pam]
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Allelic Composition: Rac2M4Btlr/Rac2M4Btlr
Genetic Background: C57BL/6J-Rac2M4Btlr

 MP:0010844 increased effector memory CD4-positive, alpha-beta T cell number "increased number of CD4-positive, alpha-beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000905, GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm]
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Allelic Composition: Rac2M4Btlr/Rac2M4Btlr
Genetic Background: C57BL/6J-Rac2M4Btlr

Allelic Composition: Rac2M4Btlr/Rac2+
Genetic Background: C57BL/6J-Rac2M4Btlr

 MP:0010847 increased central memory CD8 positive, alpha-beta T cell number "increased number of CD8-positive, alpha beta memory T cells with the phenotype CCR7-positive, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000907, GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:20146720]
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Allelic Composition: Rac2M4Btlr/Rac2M4Btlr
Genetic Background: C57BL/6J-Rac2M4Btlr

Allelic Composition: Rac2M4Btlr/Rac2+
Genetic Background: C57BL/6J-Rac2M4Btlr

 MP:0010850 increased effector memory CD8-positive, alpha-beta T cell number "increased number of CD8-positive, alpha beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000913, GO_REF:0000031, GOC:add, GOC:pam, PMID:20146720]
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Allelic Composition: Rac2M4Btlr/Rac2M4Btlr
Genetic Background: C57BL/6J-Rac2M4Btlr

Allelic Composition: Rac2M4Btlr/Rac2+
Genetic Background: C57BL/6J-Rac2M4Btlr

 MP:0012764 increased alpha-beta T cell number "greater number of T cells that expresses an alpha-beta T cell receptor complex" [CL:0000789]
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Allelic Composition: Rac2M4Btlr/Rac2M4Btlr
Genetic Background: C57BL/6J-Rac2M4Btlr

Allelic Composition: Rac2M4Btlr/Rac2+
Genetic Background: C57BL/6J-Rac2M4Btlr

 MP:0012765 decreased alpha-beta T cell number "reduced number of T cells that expresses an alpha-beta T cell receptor complex" [CL:0000789]
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Allelic Composition: Rac2M4Btlr/Rac2M4Btlr
Genetic Background: C57BL/6J-Rac2M4Btlr

Allelic Composition: Rac2M4Btlr/Rac2+
Genetic Background: C57BL/6J-Rac2M4Btlr

 MP:0013435 decreased CD8-positive, naive alpha-beta T cell number "reduction in the number of the naïve regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions with a CD44-low CD62L+ phenotype" [IMPC:Saran]
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Allelic Composition: Rac2M4Btlr/Rac2M4Btlr
Genetic Background: C57BL/6J-Rac2M4Btlr

Allelic Composition: Rac2M4Btlr/Rac2+
Genetic Background: C57BL/6J-Rac2M4Btlr

 MP:0020001 decreased response to antigen "decreased or weak immune response after exposure to an antigen" [GOC:NV]
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Allelic Composition: Rac2m3Btlr/Rac2m3Btlr
Genetic Background: C57BL/6J-Rac2m3Btlr

 MP:0020154 impaired humoral immune response "impaired response of the immune system that mediates secreted antibodies produced in B cells" [GOC:NV]
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Allelic Composition: Rab27am2Btlr/Rab27am2Btlr
Genetic Background: C57BL/6J-Rab27am2Btlr

Allelic Composition: Rac2m1Btlr/Rac2+
Genetic Background: C57BL/6J-Rac2m1Btlr

Allelic Composition: Rac2M4Btlr/Rac2M4Btlr
Genetic Background: C57BL/6J-Rac2M4Btlr

Allelic Composition: Rac2M4Btlr/Rac2+
Genetic Background: C57BL/6J-Rac2M4Btlr

 MP:0020316 decreased vascular endothelial cell proliferation "decrease in the expansion rate of any vascular endothelial cell population by cell division" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Rac2tm1Mddw/Rac2tm1Mddw
Genetic Background: involves: 129S/SvEv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000034116 Vav1 / P27870 / vav 1 oncogene / P15498* / vav guanine nucleotide exchange factor 1*  / reaction
 ENSMUSG00000015950 Ncf1 / Q09014 / Neutrophil cytosol factor 1 / P14598* / neutrophil cytosolic factor 1*  / complex / reaction
 ENSMUSG00000015340 Cybb / Q61093 / Cytochrome b-245 heavy chain / P04839* / cytochrome b-245 beta chain*  / reaction / complex
 ENSMUSG00000020611 Gna13 / P27601 / guanine nucleotide binding protein, alpha 13 / Q14344* / G protein subunit alpha 13*  / reaction
 ENSMUSG00000006519 Cyba / Q61462 / Cytochrome b-245 light chain / P13498* / cytochrome b-245 alpha chain*  / complex / reaction
 ENSMUSG00000026480 Ncf2 / O70145 / Neutrophil cytosol factor 2 / P19878* / neutrophil cytosolic factor 2*  / complex / reaction
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / reaction / complex
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / reaction / complex
 ENSMUSG00000040940 Q61210 / Arhgef1 / Rho guanine nucleotide exchange factor 1 / Q92888*  / reaction
 ENSMUSG00000071715 Ncf4 / P97369 / Neutrophil cytosol factor 4 / Q15080* / neutrophil cytosolic factor 4*  / complex / reaction






 

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