ENSMUSG00000046768


Mus musculus

Features
Gene ID: ENSMUSG00000046768
  
Biological name :Rhoj
  
Synonyms : Q9ER71 / ras homolog family member J / Rhoj
  
Possible biological names infered from orthology : Q9H4E5
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: C3
Gene start: 75308322
Gene end: 75401456
  
Corresponding Affymetrix probe sets: 10396476 (MoGene1.0st)   1418892_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000112379
Ensembl peptide - ENSMUSP00000113165
Ensembl peptide - ENSMUSP00000134552
Ensembl peptide - ENSMUSP00000059498
NCBI entrez gene - 80837     See in Manteia.
MGI - MGI:1931551
RefSeq - NM_023275
RefSeq Peptide - NP_075764
swissprot - Q9ER71
swissprot - D3YX61
swissprot - F2Z463
swissprot - G3UZM2
Ensembl - ENSMUSG00000046768
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rhojENSDARG00000020250Danio rerio
 RHOJENSGALG00000011855Gallus gallus
 RHOJENSG00000126785Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rhoq / Q8R527 / Rho-related GTP-binding protein RhoQ / P17081* / ras homolog family member Q*ENSMUSG0000002414373
Cdc42 / P60766 / Cell division control ENSMUSG0000000669956
Rac3 / P60764 / RAS-related C3 botulinum substrate 3 / P60763* / Rac family small GTPase 3*ENSMUSG0000001801253
Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*ENSMUSG0000000184753
Rac2 / Q05144 / Ras-related C3 botulinum toxin substrate 2 / P15153* / Rac family small GTPase 2*ENSMUSG0000003322052
Rhog / P84096 / ras homolog family member G / P84095*ENSMUSG0000007398246
Rhou / Q9EQT3 / Rho-related GTP-binding protein RhoU / Q7L0Q8* / ras homolog family member U*ENSMUSG0000003996046
Rhov / Q8VDU1 / Rho-related GTP-binding protein RhoV / Q96L33* / ras homolog family member V*ENSMUSG0000003422644
Q91V93 / Rhobtb2 / Rho-related BTB domain-containing protein 2 / Q9BYZ6* / Rho related BTB domain containing 2*ENSMUSG0000002207532
Q9DAK3 / Rhobtb1 / Rho-related BTB domain-containing protein 1 / O94844* / Rho related BTB domain containing 1*ENSMUSG0000001994432


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR003578  Small GTPase superfamily, Rho type
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0007266 Rho protein signal transduction IDA
 biological_processGO:0008360 regulation of cell shape IDA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0061299 retina vasculature morphogenesis in camera-type eye IMP
 biological_processGO:0090050 positive regulation of cell migration involved in sprouting angiogenesis IEA
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001273 decreased metastatic potential 
Show

Allelic Composition: Myo5ad-l35J/Myo5ad-l35J
Genetic Background: involves: C57BL/6J

Allelic Composition: Rhojtm1.2Auem/Rhojtm1.2Auem
Genetic Background: B6.Cg-Rhojtm1.2Auem

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
Show

Allelic Composition: Myo5ad-l35J/Myo5ad-l35J
Genetic Background: involves: C57BL/6J

Allelic Composition: Rhojtm1.1Auem/Rhojtm1.1Auem,Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background: involves: C57BL/6 * CBA/JNCrlj

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Zfp36tm1.2Xen/Zfp36tm1.2Xen
Genetic Background: C57BL/6-Zfp36tm1.2Xen

 MP:0002908 delayed wound healing "longer time requirement for the ability to self-repair and close wounds than normal" [J:63037]
Show

Allelic Composition: Myo5ad-l35J/Myo5ad-l35J
Genetic Background: involves: C57BL/6J

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
Show

Allelic Composition: Myo5ad-l35J/Myo5ad-l35J
Genetic Background: involves: C57BL/6J

Allelic Composition: Rhojtm1.2Auem/Rhojtm1.2Auem
Genetic Background: B6.Cg-Rhojtm1.2Auem

Allelic Composition: Rhojtm1.1Auem/Rhojtm1.1Auem,Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background: involves: C57BL/6 * CBA/JNCrlj

 MP:0003448 altered tumor morphology "changes in the expected pathology for a given tumor type compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rhojtm1.2Auem/Rhojtm1.2Auem
Genetic Background: B6.Cg-Rhojtm1.2Auem

Allelic Composition: Rhojtm1.1Auem/Rhojtm1.1Auem,Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background: involves: C57BL/6 * CBA/JNCrlj

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rhojtm1.2Auem/Rhojtm1.2Auem
Genetic Background: B6.Cg-Rhojtm1.2Auem

 MP:0010144 abnormal tumor vascularization "aberrant process of blood vessel formation and the subsequent remodeling process within and/or around tumors" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo5ad-l35J/Myo5ad-l35J
Genetic Background: involves: C57BL/6J

Allelic Composition: Rhojtm1.2Auem/Rhojtm1.2Auem
Genetic Background: B6.Cg-Rhojtm1.2Auem

Allelic Composition: Rhojtm1.1Auem/Rhojtm1.1Auem,Tg(Cdh5-cre/ERT2)1Rha/0
Genetic Background: involves: C57BL/6 * CBA/JNCrlj

 MP:0010269 decreased mammary gland tumor incidence "less than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo5ad-l35J/Myo5ad-l35J
Genetic Background: involves: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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