ENSMUSG00000018012


Mus musculus

Features
Gene ID: ENSMUSG00000018012
  
Biological name :Rac3
  
Synonyms : P60764 / Rac3 / RAS-related C3 botulinum substrate 3
  
Possible biological names infered from orthology : P60763 / Rac family small GTPase 3
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: E2
Gene start: 120721470
Gene end: 120723969
  
Corresponding Affymetrix probe sets: 10383472 (MoGene1.0st)   1420554_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000119523
Ensembl peptide - ENSMUSP00000018156
NCBI entrez gene - 170758     See in Manteia.
MGI - MGI:2180784
RefSeq - NM_133223
RefSeq Peptide - NP_573486
swissprot - A2AC13
swissprot - P60764
swissprot - Q14A12
Ensembl - ENSMUSG00000018012
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rac3aENSDARG00000090062Danio rerio
 rac3bENSDARG00000020795Danio rerio
 RAC3ENSGALG00000040606Gallus gallus
 RAC3ENSG00000169750Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*ENSMUSG0000000184793
Rac2 / Q05144 / Ras-related C3 botulinum toxin substrate 2 / P15153* / Rac family small GTPase 2*ENSMUSG0000003322088
Rhog / P84096 / ras homolog family member G / P84095*ENSMUSG0000007398270
Cdc42 / P60766 / Cell division control ENSMUSG0000000669969
Rhoq / Q8R527 / Rho-related GTP-binding protein RhoQ / P17081* / ras homolog family member Q*ENSMUSG0000002414362
Rhoj / Q9ER71 / ras homolog family member J / Q9H4E5*ENSMUSG0000004676859
Rhou / Q9EQT3 / Rho-related GTP-binding protein RhoU / Q7L0Q8* / ras homolog family member U*ENSMUSG0000003996056
Rhov / Q8VDU1 / Rho-related GTP-binding protein RhoV / Q96L33* / ras homolog family member V*ENSMUSG0000003422653
Q9DAK3 / Rhobtb1 / Rho-related BTB domain-containing protein 1 / O94844* / Rho related BTB domain containing 1*ENSMUSG0000001994443
Q91V93 / Rhobtb2 / Rho-related BTB domain-containing protein 2 / Q9BYZ6* / Rho related BTB domain containing 2*ENSMUSG0000002207543


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR003578  Small GTPase superfamily, Rho type
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0014041 regulation of neuron maturation IGI
 biological_processGO:0021894 cerebral cortex GABAergic interneuron development IGI
 biological_processGO:0022604 regulation of cell morphogenesis IGI
 biological_processGO:0030031 cell projection assembly IEA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0031175 neuron projection development IDA
 biological_processGO:0033630 positive regulation of cell adhesion mediated by integrin IEA
 biological_processGO:0048873 homeostasis of number of cells within a tissue IGI
 biological_processGO:0050885 neuromuscular process controlling balance IMP
 biological_processGO:0050905 neuromuscular process IMP
 biological_processGO:0051932 synaptic transmission, GABAergic IGI
 biological_processGO:1900026 positive regulation of substrate adhesion-dependent cell spreading IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0012505 endomembrane system ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0031941 filamentous actin IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 cellular_componentGO:0071944 cell periphery IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0048306 calcium-dependent protein binding IEA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle
PCP/CE pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001407 short stride length "reduced average distance between steps" [J:34193]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
Show

Allelic Composition: Tlx1tm1Thr/Tlx1tm1Thr
Genetic Background: involves: 129P2/OlaHsd * MF1

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tlx1tm1Thr/Tlx1tm1Thr
Genetic Background: involves: 129P2/OlaHsd * MF1

 MP:0002804 abnormal motor learning "defects in the ability to repeat a motor task requiring well coordinated movements and balance; measures cerebellar dependent learning" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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