ENSG00000169750


Homo sapiens

Features
Gene ID: ENSG00000169750
  
Biological name :RAC3
  
Synonyms : P60763 / RAC3 / Rac family small GTPase 3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q25.3
Gene start: 82031624
Gene end: 82034204
  
Corresponding Affymetrix probe sets: 206103_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000304283
Ensembl peptide - ENSP00000462421
Ensembl peptide - ENSP00000463590
NCBI entrez gene - 5881     See in Manteia.
OMIM - 602050
RefSeq - NM_005052
RefSeq - NM_001316307
RefSeq Peptide - NP_001303236
RefSeq Peptide - NP_005043
swissprot - P60763
swissprot - J3KSC4
swissprot - J3QLK0
Ensembl - ENSG00000169750
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rac3aENSDARG00000090062Danio rerio
 rac3bENSDARG00000020795Danio rerio
 RAC3ENSGALG00000040606Gallus gallus
 Rac3ENSMUSG00000018012Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RAC1 / P63000 / Rac family small GTPase 1ENSG0000013623893
RAC2 / P15153 / Rac family small GTPase 2ENSG0000012834089
RHOG / P84095 / ras homolog family member GENSG0000017710570
CDC42 / P60953 / cell division cycle 42ENSG0000007083169
RHOQ / P17081 / ras homolog family member QENSG0000011972963
RHOJ / Q9H4E5 / ras homolog family member JENSG0000012678559
RHOU / Q7L0Q8 / ras homolog family member UENSG0000011657456
RHOV / Q96L33 / ras homolog family member VENSG0000010414053
O94844 / RHOBTB1 / Rho related BTB domain containing 1ENSG0000007242244
Q9BYZ6 / RHOBTB2 / Rho related BTB domain containing 2ENSG0000000885343


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR003578  Small GTPase superfamily, Rho type
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0014041 regulation of neuron maturation IEA
 biological_processGO:0021894 cerebral cortex GABAergic interneuron development IEA
 biological_processGO:0022604 regulation of cell morphogenesis IEA
 biological_processGO:0030031 cell projection assembly IDA
 biological_processGO:0030036 actin cytoskeleton organization IDA
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0033630 positive regulation of cell adhesion mediated by integrin IDA
 biological_processGO:0035556 intracellular signal transduction TAS
 biological_processGO:0048873 homeostasis of number of cells within a tissue IEA
 biological_processGO:0050885 neuromuscular process controlling balance IEA
 biological_processGO:0050905 neuromuscular process IEA
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 biological_processGO:0051932 synaptic transmission, GABAergic IEA
 biological_processGO:1900026 positive regulation of substrate adhesion-dependent cell spreading IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030426 growth cone IDA
 cellular_componentGO:0031941 filamentous actin IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0071944 cell periphery IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0048306 calcium-dependent protein binding IPI


Pathways (from Reactome)
Pathway description
Rho GTPase cycle
PCP/CE pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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