ENSG00000177105


Homo sapiens

Features
Gene ID: ENSG00000177105
  
Biological name :RHOG
  
Synonyms : P84095 / ras homolog family member G / RHOG
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: p15.4
Gene start: 3826978
Gene end: 3840983
  
Corresponding Affymetrix probe sets: 203175_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000339467
Ensembl peptide - ENSP00000380175
Ensembl peptide - ENSP00000380176
Ensembl peptide - ENSP00000436932
NCBI entrez gene - 391     See in Manteia.
OMIM - 179505
RefSeq - XM_017017719
RefSeq - NM_001665
RefSeq - XM_005252916
RefSeq Peptide - NP_001656
swissprot - Q6ICQ8
swissprot - P84095
Ensembl - ENSG00000177105
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rhogaENSDARG00000068653Danio rerio
 rhogbENSDARG00000004301Danio rerio
 RHOGENSGALG00000026995Gallus gallus
 RhogENSMUSG00000073982Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RAC2 / P15153 / Rac family small GTPase 2ENSG0000012834072
RAC1 / P63000 / Rac family small GTPase 1ENSG0000013623872
RAC3 / P60763 / Rac family small GTPase 3ENSG0000016975070
CDC42 / P60953 / cell division cycle 42ENSG0000007083161
RHOQ / P17081 / ras homolog family member QENSG0000011972955
RHOJ / Q9H4E5 / ras homolog family member JENSG0000012678552
RHOU / Q7L0Q8 / ras homolog family member UENSG0000011657449
RHOV / Q96L33 / ras homolog family member VENSG0000010414047
Q9BYZ6 / RHOBTB2 / Rho related BTB domain containing 2ENSG0000000885342
O94844 / RHOBTB1 / Rho related BTB domain containing 1ENSG0000007242242


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR003578  Small GTPase superfamily, Rho type
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0007266 Rho protein signal transduction IDA
 biological_processGO:0008284 positive regulation of cell proliferation TAS
 biological_processGO:0016601 Rac protein signal transduction IDA
 biological_processGO:0030036 actin cytoskeleton organization IDA
 biological_processGO:0030168 platelet activation TAS
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 biological_processGO:0060326 cell chemotaxis IMP
 biological_processGO:0090630 activation of GTPase activity IMP
 biological_processGO:1900027 regulation of ruffle assembly IEA
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030667 secretory granule membrane TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
Rho GTPase cycle
G alpha (12/13) signalling events
RHO GTPases activate KTN1
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000121879 P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha  / reaction / complex
 ENSG00000141968 VAV1 / P15498 / vav guanine nucleotide exchange factor 1  / reaction
 ENSG00000145675 P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1  / reaction / complex
 ENSG00000126777 KTN1 / Q86UP2 / kinectin 1  / reaction / complex
 ENSG00000076928 Q92888 / ARHGEF1 / Rho guanine nucleotide exchange factor 1  / reaction
 ENSG00000134215 VAV3 / Q9UKW4 / vav guanine nucleotide exchange factor 3  / reaction
 ENSG00000155980 KIF5A / Q12840 / kinesin family member 5A  / reaction / complex
 ENSG00000174996 KLC2 / Q9H0B6 / kinesin light chain 2  / complex / reaction
 ENSG00000126214 KLC1 / Q07866 / kinesin light chain 1  / complex / reaction
 ENSG00000160293 VAV2 / P52735 / vav guanine nucleotide exchange factor 2  / reaction
 ENSG00000120063 GNA13 / Q14344 / G protein subunit alpha 13  / reaction






 

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