ENSG00000120063


Homo sapiens

Features
Gene ID: ENSG00000120063
  
Biological name :GNA13
  
Synonyms : GNA13 / G protein subunit alpha 13 / Q14344
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q24.1
Gene start: 65010715
Gene end: 65056839
  
Corresponding Affymetrix probe sets: 206917_at (Human Genome U133 Plus 2.0 Array)   224761_at (Human Genome U133 Plus 2.0 Array)   227539_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000439647
Ensembl peptide - ENSP00000400717
NCBI entrez gene - 10672     See in Manteia.
OMIM - 604406
RefSeq - NM_001282425
RefSeq - NM_006572
RefSeq Peptide - NP_001269354
RefSeq Peptide - NP_006563
swissprot - Q14344
swissprot - A0A024R8M0
Ensembl - ENSG00000120063
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gna13aENSDARG00000073765Danio rerio
 gna13bENSDARG00000037924Danio rerio
 GNA13ENSGALG00000036028Gallus gallus
 Gna13ENSMUSG00000020611Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GNA12 / Q03113 / G protein subunit alpha 12ENSG0000014653563
GNAQ / P50148 / G protein subunit alpha qENSG0000015605245
GNA11 / P29992 / G protein subunit alpha 11ENSG0000008825644
GNA14 / O95837 / G protein subunit alpha 14ENSG0000015604943
GNAO1 / P09471 / G protein subunit alpha o1ENSG0000008725839
GNA15 / P30679 / G protein subunit alpha 15ENSG0000006055839
GNAI2 / P04899 / G protein subunit alpha i2ENSG0000011435338
GNAI1 / P63096 / G protein subunit alpha i1ENSG0000012795537
GNAT3 / A8MTJ3 / G protein subunit alpha transducin 3ENSG0000021441536
GNAT1 / P11488 / G protein subunit alpha transducin 1ENSG0000011434936
GNAI3 / P08754 / G protein subunit alpha i3ENSG0000006513536
GNAZ / P19086 / G protein subunit alpha zENSG0000012826636
GNAT2 / P19087 / G protein subunit alpha transducin 2ENSG0000013418336


Protein motifs (from Interpro)
Interpro ID Name
 IPR000469  G-protein alpha subunit, group 12/13
 IPR001019  Guanine nucleotide binding protein (G-protein), alpha subunit
 IPR011025  G protein alpha subunit, helical insertion
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001569 branching involved in blood vessel morphogenesis IEA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IBA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0007266 Rho protein signal transduction IBA
 biological_processGO:0008360 regulation of cell shape IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030168 platelet activation TAS
 biological_processGO:0030334 regulation of cell migration IEA
 biological_processGO:0031584 activation of phospholipase D activity IBA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043065 positive regulation of apoptotic process TAS
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005834 heterotrimeric G-protein complex IBA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031526 brush border membrane IBA
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IEA
 molecular_functionGO:0003924 GTPase activity TAS
 molecular_functionGO:0004871 obsolete signal transducer activity IBA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019001 guanyl nucleotide binding IEA
 molecular_functionGO:0031683 G-protein beta/gamma-subunit complex binding IBA
 molecular_functionGO:0031702 type 1 angiotensin receptor binding IBA
 molecular_functionGO:0031752 D5 dopamine receptor binding IBA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events
Thromboxane signalling through TP receptor
Thrombin signalling through proteinase activated receptors (PARs)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000127533 F2RL3 / Q96RI0 / F2R like thrombin or trypsin receptor 3  / complex / reaction
 ENSG00000164050 O43157 / PLXNB1 / plexin B1  / reaction / complex
 ENSG00000164220 F2RL2 / O00254 / coagulation factor II thrombin receptor like 2  / complex / reaction
 ENSG00000181104 F2R / P25116 / coagulation factor II thrombin receptor  / complex / reaction
 ENSG00000076928 Q92888 / ARHGEF1 / Rho guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000186469 GNG2 / P59768 / G protein subunit gamma 2  / reaction / complex
 ENSG00000196914 Q9NZN5 / ARHGEF12 / Rho guanine nucleotide exchange factor 12  / complex / reaction
 ENSG00000006638 P21731 / TBXA2R / thromboxane A2 receptor  / reaction / complex
 ENSG00000078369 GNB1 / P62873 / G protein subunit beta 1  / reaction / complex
 ENSG00000171873 ADRA1D / P25100 / adrenoceptor alpha 1D  / reaction / complex
 ENSG00000170214 ADRA1B / P35368 / adrenoceptor alpha 1B  / complex / reaction
 ENSG00000120907 ADRA1A / P35348 / adrenoceptor alpha 1A  / reaction / complex
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / reaction
 ENSG00000177105 RHOG / P84095 / ras homolog family member G  / reaction
 ENSG00000067560 RHOA / P61586 / ras homolog family member A  / reaction
 ENSG00000128340 RAC2 / P15153 / Rac family small GTPase 2  / reaction






 

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