ENSG00000164220


Homo sapiens

Features
Gene ID: ENSG00000164220
  
Biological name :F2RL2
  
Synonyms : coagulation factor II thrombin receptor like 2 / F2RL2 / O00254
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: q13.3
Gene start: 76615482
Gene end: 76623434
  
Corresponding Affymetrix probe sets: 206795_at (Human Genome U133 Plus 2.0 Array)   230147_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000296641
Ensembl peptide - ENSP00000426703
NCBI entrez gene - 2151     See in Manteia.
OMIM - 601919
RefSeq - NM_001256566
RefSeq - NM_004101
RefSeq Peptide - NP_001243495
RefSeq Peptide - NP_004092
swissprot - O00254
Ensembl - ENSG00000164220
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01071020.1ENSDARG00000079472Danio rerio
 f2rl2ENSDARG00000090524Danio rerio
 F2RL2ENSGALG00000023379Gallus gallus
 F2rl2ENSMUSG00000021675Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
F2R / P25116 / coagulation factor II thrombin receptorENSG0000018110431
F2RL1 / P55085 / F2R like trypsin receptor 1ENSG0000016425130
F2RL3 / Q96RI0 / F2R like thrombin or trypsin receptor 3ENSG0000012753330
P2RY8 / Q86VZ1 / P2Y receptor family member 8ENSG0000018216226
GPR4 / P46093 / G protein-coupled receptor 4ENSG0000017746423
GPR132 / Q9UNW8 / G protein-coupled receptor 132ENSG0000018348422
GPR68 / Q15743 / G protein-coupled receptor 68ENSG0000011971421
GPR65 / Q8IYL9 / G protein-coupled receptor 65ENSG0000014003020
FFAR2 / O15552 / free fatty acid receptor 2ENSG0000012626219
GPR42 / O15529 / G protein-coupled receptor 42 (gene/pseudogene)ENSG0000012625118
FFAR3 / O14843 / free fatty acid receptor 3ENSG0000018589718
FFAR1 / O14842 / free fatty acid receptor 1ENSG0000012626614


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR003912  Protease-activated receptor
 IPR003943  Protease-activated receptor 3
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007596 blood coagulation TAS
 biological_processGO:0007599 hemostasis IEA
 biological_processGO:0009611 response to wounding TAS
 biological_processGO:0030168 platelet activation TAS
 biological_processGO:0035025 positive regulation of Rho protein signal transduction IBA
 biological_processGO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IBA
 biological_processGO:0070493 thrombin-activated receptor signaling pathway IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0032991 protein-containing complex IDA
 molecular_functionGO:0004435 phosphatidylinositol phospholipase C activity TAS
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015057 thrombin-activated receptor activity TAS


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (q) signalling events
Thrombin signalling through proteinase activated receptors (PARs)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000088256 GNA11 / P29992 / G protein subunit alpha 11  / complex / reaction
 ENSG00000127533 F2RL3 / Q96RI0 / F2R like thrombin or trypsin receptor 3  / reaction
 ENSG00000060558 GNA15 / P30679 / G protein subunit alpha 15  / reaction / complex
 ENSG00000156052 GNAQ / P50148 / G protein subunit alpha q  / reaction / complex
 ENSG00000078369 GNB1 / P62873 / G protein subunit beta 1  / reaction / complex
 ENSG00000164220 F2RL2 / O00254 / coagulation factor II thrombin receptor like 2  / reaction
 ENSG00000120063 GNA13 / Q14344 / G protein subunit alpha 13  / reaction / complex
 ENSG00000181104 F2R / P25116 / coagulation factor II thrombin receptor  / reaction
 ENSG00000146535 GNA12 / Q03113 / G protein subunit alpha 12  / complex / reaction
 ENSG00000180210 F2 / P00734 / coagulation factor II, thrombin  / complex / reaction
 ENSG00000156049 GNA14 / O95837 / G protein subunit alpha 14  / complex / reaction
 ENSG00000186469 GNG2 / P59768 / G protein subunit gamma 2  / complex / reaction






 

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