ENSG00000140030


Homo sapiens

Features
Gene ID: ENSG00000140030
  
Biological name :GPR65
  
Synonyms : GPR65 / G protein-coupled receptor 65 / Q8IYL9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: 1
Band: q31.3
Gene start: 88005124
Gene end: 88014811
  
Corresponding Affymetrix probe sets: 214467_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000267549
NCBI entrez gene - 8477     See in Manteia.
OMIM - 604620
RefSeq - NM_003608
RefSeq Peptide - NP_003599
swissprot - B5B0C2
swissprot - Q8IYL9
Ensembl - ENSG00000140030
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gpr65ENSDARG00000045957Danio rerio
 GPR65ENSGALG00000010595Gallus gallus
 Gpr65ENSMUSG00000021886Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GPR4 / P46093 / G protein-coupled receptor 4ENSG0000017746439
GPR68 / Q15743 / G protein-coupled receptor 68ENSG0000011971434
GPR132 / Q9UNW8 / G protein-coupled receptor 132ENSG0000018348428
F2RL1 / P55085 / F2R like trypsin receptor 1ENSG0000016425125
F2R / P25116 / coagulation factor II thrombin receptorENSG0000018110424
F2RL3 / Q96RI0 / F2R like thrombin or trypsin receptor 3ENSG0000012753323
P2RY8 / Q86VZ1 / P2Y receptor family member 8ENSG0000018216223
F2RL2 / O00254 / coagulation factor II thrombin receptor like 2ENSG0000016422022
FFAR2 / O15552 / free fatty acid receptor 2ENSG0000012626219
FFAR3 / O14843 / free fatty acid receptor 3ENSG0000018589718
GPR42 / O15529 / G protein-coupled receptor 42 (gene/pseudogene)ENSG0000012625118
FFAR1 / O14842 / free fatty acid receptor 1ENSG0000012626614


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR005464  Psychosine receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0006955 immune response TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007275 multicellular organism development TAS
 biological_processGO:0010447 response to acidic pH IDA
 biological_processGO:0031532 actin cytoskeleton reorganization IDA
 biological_processGO:0035025 positive regulation of Rho protein signal transduction IBA
 biological_processGO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IBA
 biological_processGO:0051496 positive regulation of stress fiber assembly IDA
 biological_processGO:0090630 activation of GTPase activity IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IDA


Pathways (from Reactome)
Pathway description
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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