ENSG00000164251


Homo sapiens

Features
Gene ID: ENSG00000164251
  
Biological name :F2RL1
  
Synonyms : F2RL1 / F2R like trypsin receptor 1 / P55085
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q13.3
Gene start: 76818933
Gene end: 76835315
  
Corresponding Affymetrix probe sets: 206429_at (Human Genome U133 Plus 2.0 Array)   213506_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000296677
Ensembl peptide - ENSP00000425622
NCBI entrez gene - 2150     See in Manteia.
OMIM - 600933
RefSeq - NM_005242
RefSeq - XM_017009223
RefSeq Peptide - NP_005233
swissprot - D6RJH3
swissprot - P55085
Ensembl - ENSG00000164251
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 f2rl1.1ENSDARG00000068856Danio rerio
 f2rl1.2ENSDARG00000077540Danio rerio
 F2RL1ENSGALG00000014984Gallus gallus
 F2rl1ENSMUSG00000021678Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
F2R / P25116 / coagulation factor II thrombin receptorENSG0000018110434
F2RL3 / Q96RI0 / F2R like thrombin or trypsin receptor 3ENSG0000012753329
F2RL2 / O00254 / coagulation factor II thrombin receptor like 2ENSG0000016422029
P2RY8 / Q86VZ1 / P2Y receptor family member 8ENSG0000018216228
FFAR3 / O14843 / free fatty acid receptor 3ENSG0000018589722
GPR4 / P46093 / G protein-coupled receptor 4ENSG0000017746422
GPR42 / O15529 / G protein-coupled receptor 42 (gene/pseudogene)ENSG0000012625122
GPR68 / Q15743 / G protein-coupled receptor 68ENSG0000011971421
GPR65 / Q8IYL9 / G protein-coupled receptor 65ENSG0000014003021
GPR132 / Q9UNW8 / G protein-coupled receptor 132ENSG0000018348420
FFAR2 / O15552 / free fatty acid receptor 2ENSG0000012626219
FFAR1 / O14842 / free fatty acid receptor 1ENSG0000012626616


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR002281  Protease-activated receptor 2
 IPR003912  Protease-activated receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002286 T cell activation involved in immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002690 positive regulation of leukocyte chemotaxis IDA
 biological_processGO:0002741 positive regulation of cytokine secretion involved in immune response IDA
 biological_processGO:0003104 positive regulation of glomerular filtration IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007596 blood coagulation IEA
 biological_processGO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway IDA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0030193 regulation of blood coagulation IDA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030836 positive regulation of actin filament depolymerization IDA
 biological_processGO:0031274 positive regulation of pseudopodium assembly IEA
 biological_processGO:0032930 positive regulation of superoxide anion generation IDA
 biological_processGO:0034137 positive regulation of toll-like receptor 2 signaling pathway IMP
 biological_processGO:0034140 negative regulation of toll-like receptor 3 signaling pathway IMP
 biological_processGO:0034141 positive regulation of toll-like receptor 3 signaling pathway IMP
 biological_processGO:0034145 positive regulation of toll-like receptor 4 signaling pathway IDA
 biological_processGO:0035025 positive regulation of Rho protein signal transduction IEA
 biological_processGO:0035926 chemokine (C-C motif) ligand 2 secretion IDA
 biological_processGO:0042119 neutrophil activation IDA
 biological_processGO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling IDA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
 biological_processGO:0043311 positive regulation of eosinophil degranulation IDA
 biological_processGO:0043547 positive regulation of GTPase activity IMP
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045217 cell-cell junction maintenance IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0046328 regulation of JNK cascade IDA
 biological_processGO:0046329 negative regulation of JNK cascade IDA
 biological_processGO:0046330 positive regulation of JNK cascade IDA
 biological_processGO:0050702 interleukin-1 beta secretion IDA
 biological_processGO:0050900 leukocyte migration IDA
 biological_processGO:0050921 positive regulation of chemotaxis IEA
 biological_processGO:0050927 positive regulation of positive chemotaxis IDA
 biological_processGO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IBA
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0060100 positive regulation of phagocytosis, engulfment IDA
 biological_processGO:0061028 establishment of endothelial barrier IDA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070493 thrombin-activated receptor signaling pathway IEA
 biological_processGO:0070661 leukocyte proliferation IEA
 biological_processGO:0070963 positive regulation of neutrophil mediated killing of gram-negative bacterium IDA
 biological_processGO:0072608 interleukin-10 secretion IDA
 biological_processGO:0072643 interferon-gamma secretion IEA
 biological_processGO:0090195 chemokine secretion IDA
 biological_processGO:0090198 negative regulation of chemokine secretion IDA
 biological_processGO:0097029 mature conventional dendritic cell differentiation IEA
 biological_processGO:0097755 positive regulation of blood vessel diameter IEA
 biological_processGO:1900135 positive regulation of renin secretion into blood stream IEA
 biological_processGO:2000484 positive regulation of interleukin-8 secretion IDA
 biological_processGO:2000778 positive regulation of interleukin-6 secretion IDA
 cellular_componentGO:0005769 early endosome IDA
 cellular_componentGO:0005794 Golgi apparatus TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031143 pseudopodium IEA
 molecular_functionGO:0001965 G-protein alpha-subunit binding IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity TAS
 molecular_functionGO:0005102 signaling receptor binding TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015057 thrombin-activated receptor activity IEA
 molecular_functionGO:0031681 G-protein beta-subunit binding IEA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000180210 F2 / P00734 / coagulation factor II, thrombin  / reaction / complex






 

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