ENSGALG00000014984


Gallus gallus

Features
Gene ID: ENSGALG00000014984
  
Biological name :F2RL1
  
Synonyms : F2RL1 / F2R like trypsin receptor 1
  
Possible biological names infered from orthology : P55085 / P55086 / Proteinase-activated receptor 2
  
Species: Gallus gallus
  
Chr. number: Z
Strand: -1
Band:
Gene start: 23413421
Gene end: 23422623
  
Corresponding Affymetrix probe sets: GgaAffx.12054.1.S1_s_at (Chicken Array)   GgaAffx.9516.1.A1_at (Chicken Array)   GgaAffx.9516.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000024125
NCBI entrez gene - 427213     See in Manteia.
RefSeq - NM_001012608
RefSeq Peptide - NP_001012626
swissprot - Q5F4D0
Ensembl - ENSGALG00000014984
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 f2rl1.1ENSDARG00000068856Danio rerio
 f2rl1.2ENSDARG00000077540Danio rerio
 F2RL1ENSG00000164251Homo sapiens
 F2rl1ENSMUSG00000021678Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
F2RL3 / F2R like thrombin or trypsin receptor 3 / O88634* / Q96RI0* / Proteinase-activated receptor 4 *ENSGALG0000004448535
ENSGALG0000000257032
F2RL2 / coagulation factor II thrombin receptor like 2 / O00254* / O08675* / Proteinase-activated receptor 3 *ENSGALG0000002337931
P2RY8 / Q5ZI82 / P2Y purinoceptor 8 / Q86VZ1* / P2Y receptor family member 8*ENSGALG0000001668731
F2R / coagulation factor II thrombin receptor / P25116* / P30558* / Proteinase-activated receptor 1 *ENSGALG0000001498326
GPR68 / G protein-coupled receptor 68 / Q15743* / Q8BFQ3* / Ovarian cancer G-protein coupled receptor 1 *ENSGALG0000001070721
GPR65 / G protein-coupled receptor 65 / Q8IYL9*ENSGALG0000001059520
GPR132 / G protein-coupled receptor 132 / Q9UNW8* / Q9Z282*ENSGALG0000002740719


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR002281  Protease-activated receptor 2
 IPR003912  Protease-activated receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002286 T cell activation involved in immune response IEA
 biological_processGO:0002690 positive regulation of leukocyte chemotaxis IEA
 biological_processGO:0002741 positive regulation of cytokine secretion involved in immune response IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007596 blood coagulation IEA
 biological_processGO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0030193 regulation of blood coagulation IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030836 positive regulation of actin filament depolymerization IEA
 biological_processGO:0031274 positive regulation of pseudopodium assembly IEA
 biological_processGO:0032930 positive regulation of superoxide anion generation IEA
 biological_processGO:0034137 positive regulation of toll-like receptor 2 signaling pathway IEA
 biological_processGO:0034140 negative regulation of toll-like receptor 3 signaling pathway IEA
 biological_processGO:0034141 positive regulation of toll-like receptor 3 signaling pathway IEA
 biological_processGO:0034145 positive regulation of toll-like receptor 4 signaling pathway IEA
 biological_processGO:0035025 positive regulation of Rho protein signal transduction IEA
 biological_processGO:0035926 chemokine (C-C motif) ligand 2 secretion IEA
 biological_processGO:0042119 neutrophil activation IEA
 biological_processGO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043311 positive regulation of eosinophil degranulation IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045217 cell-cell junction maintenance IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046328 regulation of JNK cascade IEA
 biological_processGO:0046329 negative regulation of JNK cascade IEA
 biological_processGO:0046330 positive regulation of JNK cascade IEA
 biological_processGO:0050702 interleukin-1 beta secretion IEA
 biological_processGO:0050900 leukocyte migration IEA
 biological_processGO:0050921 positive regulation of chemotaxis IEA
 biological_processGO:0050927 positive regulation of positive chemotaxis IEA
 biological_processGO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IBA
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0060100 positive regulation of phagocytosis, engulfment IEA
 biological_processGO:0061028 establishment of endothelial barrier IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070493 thrombin-activated receptor signaling pathway IEA
 biological_processGO:0070661 leukocyte proliferation IEA
 biological_processGO:0070963 positive regulation of neutrophil mediated killing of gram-negative bacterium IEA
 biological_processGO:0072608 interleukin-10 secretion IEA
 biological_processGO:0072643 interferon-gamma secretion IEA
 biological_processGO:0090195 chemokine secretion IEA
 biological_processGO:0090198 negative regulation of chemokine secretion IEA
 biological_processGO:0097029 mature conventional dendritic cell differentiation IEA
 biological_processGO:0097755 positive regulation of blood vessel diameter IEA
 biological_processGO:1900135 positive regulation of renin secretion into blood stream IEA
 biological_processGO:2000484 positive regulation of interleukin-8 secretion IEA
 biological_processGO:2000778 positive regulation of interleukin-6 secretion IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031143 pseudopodium IEA
 molecular_functionGO:0001965 G-protein alpha-subunit binding IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IBA
 molecular_functionGO:0015057 thrombin-activated receptor activity IEA
 molecular_functionGO:0031681 G-protein beta-subunit binding IEA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000008332 F2 / prothrombin precursor / P00734* / P19221* / coagulation factor II, thrombin* / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain*  / complex / reaction






 

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