ENSGALG00000014983


Gallus gallus

Features
Gene ID: ENSGALG00000014983
  
Biological name :F2R
  
Synonyms : coagulation factor II thrombin receptor / F2R
  
Possible biological names infered from orthology : P25116 / P30558 / Proteinase-activated receptor 1
  
Species: Gallus gallus
  
Chr. number: Z
Strand: -1
Band:
Gene start: 23448238
Gene end: 23455214
  
Corresponding Affymetrix probe sets: GgaAffx.9515.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000024124
NCBI entrez gene - 427212     See in Manteia.
RefSeq - XM_424799
swissprot - F1NM53
Ensembl - ENSGALG00000014983
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 f2rENSDARG00000060012Danio rerio
 F2RENSG00000181104Homo sapiens
 F2rENSMUSG00000048376Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
F2RL1 / F2R like trypsin receptor 1 / P55085* / P55086* / Proteinase-activated receptor 2 *ENSGALG0000001498432
F2RL2 / coagulation factor II thrombin receptor like 2 / O00254* / O08675* / Proteinase-activated receptor 3 *ENSGALG0000002337928
ENSGALG0000000257028
P2RY8 / Q5ZI82 / P2Y purinoceptor 8 / Q86VZ1* / P2Y receptor family member 8*ENSGALG0000001668727
F2RL3 / F2R like thrombin or trypsin receptor 3 / O88634* / Q96RI0* / Proteinase-activated receptor 4 *ENSGALG0000004448526
GPR65 / G protein-coupled receptor 65 / Q8IYL9*ENSGALG0000001059519
GPR68 / G protein-coupled receptor 68 / Q15743* / Q8BFQ3* / Ovarian cancer G-protein coupled receptor 1 *ENSGALG0000001070719
GPR132 / G protein-coupled receptor 132 / Q9UNW8* / Q9Z282*ENSGALG0000002740717


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000935  Thrombin receptor
 IPR003912  Protease-activated receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002248 connective tissue replacement involved in inflammatory response wound healing IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007596 blood coagulation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009611 response to wounding IEA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0030168 platelet activation IEA
 biological_processGO:0030193 regulation of blood coagulation IEA
 biological_processGO:0030194 positive regulation of blood coagulation IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032651 regulation of interleukin-1 beta production IEA
 biological_processGO:0032967 positive regulation of collagen biosynthetic process IEA
 biological_processGO:0035025 positive regulation of Rho protein signal transduction IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045217 cell-cell junction maintenance IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045907 positive regulation of vasoconstriction IEA
 biological_processGO:0048873 homeostasis of number of cells within a tissue IEA
 biological_processGO:0051281 positive regulation of release of sequestered calcium ion into cytosol IEA
 biological_processGO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IBA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070493 thrombin-activated receptor signaling pathway IEA
 biological_processGO:0099553 trans-synaptic signaling by endocannabinoid, modulating synaptic transmission IEA
 biological_processGO:1900134 negative regulation of renin secretion into blood stream IEA
 biological_processGO:2000484 positive regulation of interleukin-8 secretion IEA
 biological_processGO:2000778 positive regulation of interleukin-6 secretion IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0005901 caveola IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031094 platelet dense tubular network IEA
 molecular_functionGO:0001965 G-protein alpha-subunit binding IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0015057 thrombin-activated receptor activity IBA
 molecular_functionGO:0031681 G-protein beta-subunit binding IEA


Pathways (from Reactome)
Pathway description
Common Pathway of Fibrin Clot Formation
Peptide ligand-binding receptors
G alpha (q) signalling events
Thrombin signalling through proteinase activated receptors (PARs)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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