ENSMUSG00000048376


Mus musculus

Features
Gene ID: ENSMUSG00000048376
  
Biological name :F2r
  
Synonyms : F2r / P30558 / Proteinase-activated receptor 1
  
Possible biological names infered from orthology : coagulation factor II thrombin receptor / P25116
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: D1
Gene start: 95601803
Gene end: 95618487
  
Corresponding Affymetrix probe sets: 10411229 (MoGene1.0st)   1437308_s_at (Mouse Genome 430 2.0 Array)   1450852_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000061754
NCBI entrez gene - 14062     See in Manteia.
MGI - MGI:101802
RefSeq - NM_010169
RefSeq Peptide - NP_034299
swissprot - P30558
Ensembl - ENSMUSG00000048376
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 f2rENSDARG00000060012Danio rerio
 F2RENSGALG00000014983Gallus gallus
 F2RENSG00000181104Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
F2rl1 / P55086 / Proteinase-activated receptor 2 / P55085* / F2R like trypsin receptor 1*ENSMUSG0000002167830
F2rl3 / O88634 / Proteinase-activated receptor 4 / Q96RI0* / F2R like thrombin or trypsin receptor 3*ENSMUSG0000005014727
F2rl2 / O08675 / Proteinase-activated receptor 3 / O00254* / coagulation factor II thrombin receptor like 2*ENSMUSG0000002167523
Ffar3 / Q3UFD7 / Free fatty acid receptor 3 / GPR42* / O14843* / O15529* / G protein-coupled receptor 42 (gene/pseudogene)*ENSMUSG0000001942920
Gpr65 / G protein-coupled receptor 65 / Q8IYL9*ENSMUSG0000002188619
Gpr68 / Q8BFQ3 / Ovarian cancer G-protein coupled receptor 1 / Q15743* / G protein-coupled receptor 68*ENSMUSG0000004741518
Gpr132 / Q9Z282 / G protein-coupled receptor 132 / Q9UNW8*ENSMUSG0000002129818
Gpr4 / Q8BUD0 / G-protein coupled receptor 4 / P46093*ENSMUSG0000004431718
Ffar2 / Q8VCK6 / Free fatty acid receptor 2 / O15552*ENSMUSG0000005131417
Ffar1 / Q76JU9 / Free fatty acid receptor 1 / O14842*ENSMUSG0000004445314


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000935  Thrombin receptor
 IPR003912  Protease-activated receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000186 activation of MAPKK activity ISS
 biological_processGO:0002248 connective tissue replacement involved in inflammatory response wound healing IEA
 biological_processGO:0003105 negative regulation of glomerular filtration ISS
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0006954 inflammatory response IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IDA
 biological_processGO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway ISS
 biological_processGO:0007529 establishment of synaptic specificity at neuromuscular junction ISS
 biological_processGO:0007596 blood coagulation IEA
 biological_processGO:0007599 hemostasis IEA
 biological_processGO:0008284 positive regulation of cell proliferation ISS
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009611 response to wounding IEA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IDA
 biological_processGO:0030168 platelet activation IEA
 biological_processGO:0030193 regulation of blood coagulation IEA
 biological_processGO:0030194 positive regulation of blood coagulation IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0032496 response to lipopolysaccharide IMP
 biological_processGO:0032651 regulation of interleukin-1 beta production IMP
 biological_processGO:0032967 positive regulation of collagen biosynthetic process IEA
 biological_processGO:0035025 positive regulation of Rho protein signal transduction IDA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process ISS
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045217 cell-cell junction maintenance IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045907 positive regulation of vasoconstriction IDA
 biological_processGO:0045987 positive regulation of smooth muscle contraction ISS
 biological_processGO:0048873 homeostasis of number of cells within a tissue IMP
 biological_processGO:0051209 release of sequestered calcium ion into cytosol ISS
 biological_processGO:0051281 positive regulation of release of sequestered calcium ion into cytosol IEA
 biological_processGO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway ISS
 biological_processGO:0051928 positive regulation of calcium ion transport ISS
 biological_processGO:0051930 regulation of sensory perception of pain ISS
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IDA
 biological_processGO:0070493 thrombin-activated receptor signaling pathway IGI
 biological_processGO:0099553 trans-synaptic signaling by endocannabinoid, modulating synaptic transmission IMP
 biological_processGO:1900134 negative regulation of renin secretion into blood stream IDA
 biological_processGO:2000484 positive regulation of interleukin-8 secretion IEA
 biological_processGO:2000778 positive regulation of interleukin-6 secretion IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0005901 caveola IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031094 platelet dense tubular network IEA
 cellular_componentGO:0031594 neuromuscular junction ISS
 cellular_componentGO:0045211 postsynaptic membrane ISS
 molecular_functionGO:0001965 G-protein alpha-subunit binding IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IMP
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0015057 thrombin-activated receptor activity ISO
 molecular_functionGO:0031681 G-protein beta-subunit binding IDA
 molecular_functionGO:0032795 heterotrimeric G-protein binding TAS


Pathways (from Reactome)
Pathway description
Common Pathway of Fibrin Clot Formation
Peptide ligand-binding receptors
G alpha (q) signalling events
Thrombin signalling through proteinase activated receptors (PARs)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Hap1tm2Id/Hap1tm2Id
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000135 reduced cortical bone thickness "thinner than normal superficial layer of compact bone " [J:61509]
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Allelic Composition: Hap1tm2Id/Hap1tm2Id
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000230 abnormal blood pressure "altered tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tfap2atm2Will/Tfap2atm2Will,HhatTg(TFAP2A-cre)1Will/0
Genetic Background: Not Specified

 MP:0000292 distended pericardial sacs "stretched outer parietal layer of the pericardium" [J:25248]
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Allelic Composition: Hap1tm2Id/Hap1tm2Id
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000343 altered response to myocardial infarction "change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pkd2tm2Som/Pkd2+,Pkhd1tm1Gwu/Pkhd1tm1Gwu
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Ghrhrlit/Ghrhrlit,Prlrtm1Cnp/Prlrtm1Cnp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: F2rtm1.1Cgh/F2rtm1.1Cgh,F2rl1tm2Cgh/F2rl1tm2Cgh,Tg(Tek-F2r)1Cgh/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
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Allelic Composition: Fbn2fp/Fbn2mz
Genetic Background: involves: BALB/cAnNCrl * C3H/HeH * C3HeB/FeHu * C57BL/6J

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Hap1tm2Id/Hap1tm2Id
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ghrhrlit/Ghrhrlit,Prlrtm1Cnp/Prlrtm1Cnp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Spout1tm1Mxu/Spout1+,Dffatm1Mxu/Dffatm1Mxu
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: F2rtm1Ajc/F2rtm1Ajc,F5tm1Dgi/F5tm1Dgi
Genetic Background: B6.Cg-F5tm1Dgi F2rtm1Ajc

 MP:0001712 abnormal placental development "malformed or incomplete differentiation of the organ of metabolic exchange between the fetus and mother" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Spout1tm1Mxu/Spout1+,Dffatm1Mxu/Dffatm1Mxu
Genetic Background: involves: 129 * C57BL/6

 MP:0001719 absent vitelline blood vessels "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623]
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Allelic Composition: Hap1tm2Id/Hap1tm2Id
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hap1tm2Id/Hap1tm2Id
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Ghrhrlit/Ghrhrlit,Prlrtm1Cnp/Prlrtm1Cnp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tfap2atm2Will/Tfap2atm2Will,HhatTg(TFAP2A-cre)1Will/0
Genetic Background: Not Specified

 MP:0001883 mammary adenocarcinoma "higher than normal incidence of malignant tumors of the mammary gland" [J:62919]
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Allelic Composition: T/twPas2
Genetic Background: involves: M. m. brevirostris

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hap1tm2Id/Hap1tm2Id
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: F2rtm1Ajc/F2rtm1Ajc,F5tm1Dgi/F5tm1Dgi
Genetic Background: B6.Cg-F5tm1Dgi F2rtm1Ajc

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prss8fr/Prss8+,Spint2Gt(KST272)Byg/Spint2Gt(KST272)Byg
Genetic Background: involves: 129P2/OlaHsd * DBA

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tfap2atm2Will/Tfap2atm2Will,HhatTg(TFAP2A-cre)1Will/0
Genetic Background: Not Specified

 MP:0002339 abnormal lymph node morphology "anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: CrygcM1Sbao/Crygc+
Genetic Background: involves: BALB/cJ * ICR

 MP:0003051 curly tail "a loop or corkscrew-like curl in the tail" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Ghrhrlit/Ghrhrlit,Prlrtm1Cnp/Prlrtm1Cnp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: F2rtm1Ajc/F2rtm1Ajc
Genetic Background: involves: 129S4/SvJae

Allelic Composition: F2rtm1Ajc/F2rtm1Ajc,F2rl1tm1Cgh/F2rl1tm1Cgh
Genetic Background: involves: 129S4/SvJae

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Ghrhrlit/Ghrhrlit,Prlrtm1Cnp/Prlrtm1Cnp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: F2rtm1Ajc/F2rtm1Ajc,F2rl1tm1Cgh/F2rl1tm1Cgh
Genetic Background: involves: 129S4/SvJae

 MP:0003071 decreased vascular permeability "reduced or slower ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tfap2atm2Will/Tfap2atm2Will,HhatTg(TFAP2A-cre)1Will/0
Genetic Background: Not Specified

 MP:0003202 abnormal neuron apoptosis "change in the timing or the number of neurons undergoing programmed cell death" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: F2rtm1Ajc/F2rtm1Ajc
Genetic Background: B6.129S4-F2rtm1Ajc

 MP:0003228 abnormal sinus venosus "malformation in the cavity at the caudal end of the embryonic cardiac tube in which the veins from the intra- and extraembryonic circulatory arcs unite; in the adult this becomes the portion of the right atrium known as the sinus of the vena cava" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
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Allelic Composition: F2rtm1Ajc/F2rtm1Ajc
Genetic Background: B6.129S4-F2rtm1Ajc

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: F2rtm1Ajc/F2rtm1Ajc
Genetic Background: B6.129S4-F2rtm1Ajc

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pkd2tm2Som/Pkd2+,Pkhd1tm1Gwu/Pkhd1tm1Gwu
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Spout1tm1Mxu/Spout1+,Dffatm1Mxu/Dffatm1Mxu
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: F2rtm1Ajc/F2rtm1Ajc
Genetic Background: B6.129S4-F2rtm1Ajc

 MP:0004086 absent heartbeat "lack of a spontaneously beating heart (usually due to defects in the calcium delivery mechanism or loss of a functional contractile apparatus)" [J:69362, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Spout1tm1Mxu/Spout1+,Dffatm1Mxu/Dffatm1Mxu
Genetic Background: involves: 129 * C57BL/6

 MP:0004181 abnormal carotid artery morphology "malformation of any of the four arteries (two on each side of the neck; right and left internal carotid arteries, and right and left external carotid arteries) that deliver oxygen-rich blood from the heart to the head and brain" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Tfap2atm2Will/Tfap2atm2Will,HhatTg(TFAP2A-cre)1Will/0
Genetic Background: Not Specified

 MP:0004348 long femur "increased length of the long bone of the thigh" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: F2rtm1Ajc/F2rtm1Ajc
Genetic Background: B6.129S4-F2rtm1Ajc

 MP:0004883 abnormal blood vessel healing "anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Tfap2atm2Will/Tfap2atm2Will,HhatTg(TFAP2A-cre)1Will/0
Genetic Background: Not Specified

 MP:0005085 abnormal gall bladder physiology "anomalous action or function of the organ that stores and concentrates bile " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: F2rl1tm1Mslb/F2rl1tm1Mslb
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005244 hemopericardium "bleeding into the pericardial space" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Hap1tm2Id/Hap1tm2Id
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: F2rtm1Ajc/F2rtm1Ajc,F5tm1Dgi/F5tm1Dgi
Genetic Background: B6.Cg-F5tm1Dgi F2rtm1Ajc

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: F2rtm1Ajc/F2rtm1Ajc,F5tm1Dgi/F5tm1Dgi
Genetic Background: B6.Cg-F5tm1Dgi F2rtm1Ajc

 MP:0005416 abnormal circulating protein level "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hap1tm2Id/Hap1tm2Id
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Spout1tm1Mxu/Spout1+,Dffatm1Mxu/Dffatm1Mxu
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: F2rtm1Ajc/F2rtm1Ajc
Genetic Background: B6.129S4-F2rtm1Ajc

 MP:0006315 abnormal kidney protein excretion "anomaly in the amount of protein eliminated by the kidneys" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: F2rtm1Ajc/F2rtm1Ajc
Genetic Background: B6.129S4-F2rtm1Ajc

 MP:0006316 increased urine sodium level "higher than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: F2rtm1Ajc/F2rtm1Ajc
Genetic Background: B6.129S4-F2rtm1Ajc

 MP:0008466 enlarged mesenteric lymph nodes "increased size of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: CrygcM1Sbao/Crygc+
Genetic Background: involves: BALB/cJ * ICR

 MP:0008539 decreased susceptibility to induced colitis "decreased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tfap2atm2Will/Tfap2atm2Will,HhatTg(TFAP2A-cre)1Will/0
Genetic Background: Not Specified

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: CrygcM1Sbao/Crygc+
Genetic Background: involves: BALB/cJ * ICR

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: CrygcM1Sbao/Crygc+
Genetic Background: involves: BALB/cJ * ICR

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Tc/T+,Tg(T)118.9Bgh/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0008762 embryonic lethality "death of an animal in the embryonic period (Mus: up to E14)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tc/T+,Tg(T)118.9Bgh/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Tc/T+,Tg(T)118.9Bgh/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: F2rtm2Cgh/F2rtm2Cgh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009349 increased urine pH "increased urine alkalinity" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: F2rtm1Ajc/F2rtm1Ajc
Genetic Background: B6.129S4-F2rtm1Ajc

 MP:0009660 abnormal induced retinal neovascularization "any anomaly in the response to conditions which induce the pathological growth of vessels into the retina" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: F2rtm1Pago/F2rtm1Pago,F3tm1.1Dwr/F3tm1.1Dwr
Genetic Background: B6.129-F3tm1.1Dwr F2rtm1Pago

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tc/T+,Tg(T)118.9Bgh/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0009764 decreased sensitivity to induced morbidity/mortality "increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: CrygcM1Sbao/Crygc+
Genetic Background: involves: BALB/cJ * ICR

 MP:0010155 abnormal intestine physiology "any functional anomaly of the digestive tube passing from the stomach to the anus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tfap2atm2Will/Tfap2atm2Will,HhatTg(TFAP2A-cre)1Will/0
Genetic Background: Not Specified

 MP:0010383 increased adenoma incidence "greater than the expected number of a benign epithelial neoplasm with a glandular organization, occurring in a specific population in a given time period; this tumor type usually does not invade or infiltrate surrounding tissue but may remain a benign tumor or progress to malignancy" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:C04.557.470.035]
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Allelic Composition: T/twPas2
Genetic Background: involves: M. m. brevirostris

 MP:0010695 abnormal blood pressure regulation "any anomaly in the process that modulates the force with which blood travels through the circulatory system, which is controlled by a balance of processes that increase pressure and decrease pressure" [GO:0008217]
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Allelic Composition: Tfap2atm2Will/Tfap2atm2Will,HhatTg(TFAP2A-cre)1Will/0
Genetic Background: Not Specified

 MP:0010697 abnormal systemic arterial blood pressure regulation "anomaly in the process that modulates the force with which blood travels through the systemic arterial circulatory system" [GO:0003073]
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Allelic Composition: Tfap2atm2Will/Tfap2atm2Will,HhatTg(TFAP2A-cre)1Will/0
Genetic Background: Not Specified

 MP:0010868 increased bone trabecula number "increased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: F2rtm1Ajc/F2rtm1Ajc
Genetic Background: B6.129S4-F2rtm1Ajc

 MP:0010874 abnormal bone volume "any anomaly in the amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: F2rtm1Ajc/F2rtm1Ajc
Genetic Background: B6.129S4-F2rtm1Ajc

 MP:0010878 increased trabecular bone volume "increase in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: F2rtm1Ajc/F2rtm1Ajc
Genetic Background: B6.129S4-F2rtm1Ajc

 MP:0010964 increased compact bone volume 
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Allelic Composition: F2rtm1Ajc/F2rtm1Ajc
Genetic Background: B6.129S4-F2rtm1Ajc

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: F2rtm1Ajc/F2rtm1Ajc,F5tm1Dgi/F5tm1Dgi
Genetic Background: B6.Cg-F5tm1Dgi F2rtm1Ajc

 MP:0011102 partial embryonic lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Tc/T+,Tg(T)118.9Bgh/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Tfap2atm2Will/Tfap2atm2Will,HhatTg(TFAP2A-cre)1Will/0
Genetic Background: Not Specified

Allelic Composition: F2rtm1Ajc/F2rtm1Ajc
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: F2rtm1Ajc/F2rtm1Ajc
Genetic Background: B6.129S4-F2rtm1Ajc

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: F2rtm2Cgh/F2rtm2Cgh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0013631 decreased bone trabecular spacing "decrease in the amount of space between trabeculae in cancellous bone" [MGI:jwhite]
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Allelic Composition: F2rtm1Ajc/F2rtm1Ajc
Genetic Background: B6.129S4-F2rtm1Ajc

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000149 Gna12 / P27600 / guanine nucleotide binding protein, alpha 12 / Q03113* / G protein subunit alpha 12*  / complex / reaction
 ENSMUSG00000020611 Gna13 / P27601 / guanine nucleotide binding protein, alpha 13 / Q14344* / G protein subunit alpha 13*  / complex / reaction
 ENSMUSG00000021675 F2rl2 / O08675 / Proteinase-activated receptor 3 / O00254* / coagulation factor II thrombin receptor like 2*  / reaction
 ENSMUSG00000027249 F2 / P19221 / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain / P00734* / coagulation factor II, thrombin*  / complex / reaction
 ENSMUSG00000027611 Procr / Q64695 / protein C receptor, endothelial / Q9UNN8* / protein C receptor*  / complex / reaction
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000018909 Arrb1 / Q8BWG8 / Beta-arrestin-1 / P49407* / arrestin beta 1*  / complex / reaction
 ENSMUSG00000029064 Gnb1 / P62874 / guanine nucleotide binding protein (G protein), beta 1 / P62873* / G protein subunit beta 1*  / complex / reaction
 ENSMUSG00000063358 Mapk1 / P63085 / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA. / P28482* / mitogen-activated protein kinase 1*  / reaction / complex
 ENSMUSG00000063065 Mapk3 / Q63844 / Mitogen-activated protein kinase 3 / P27361*  / complex / reaction
 ENSMUSG00000043004 Gng2 / P63213 / guanine nucleotide binding protein (G protein), gamma 2 / P59768* / G protein subunit gamma 2*  / complex / reaction
 ENSMUSG00000050147 F2rl3 / O88634 / Proteinase-activated receptor 4 / Q96RI0* / F2R like thrombin or trypsin receptor 3*  / reaction
 ENSMUSG00000048376 F2r / P30558 / Proteinase-activated receptor 1 / P25116* / coagulation factor II thrombin receptor*  / reaction
 ENSMUSG00000034781 Gna11 / P21278 / guanine nucleotide binding protein, alpha 11 / P29992* / G protein subunit alpha 11*  / reaction / complex
 ENSMUSG00000060216 Arrb2 / Q91YI4 / Beta-arrestin-2 / P32121* / arrestin beta 2*  / complex / reaction
 ENSMUSG00000024697 Gna14 / P30677 / guanine nucleotide binding protein, alpha 14 / O95837* / G protein subunit alpha 14*  / complex / reaction
 ENSMUSG00000034792 Gna15 / P30678 / guanine nucleotide binding protein, alpha 15 / P30679* / G protein subunit alpha 15*  / reaction / complex
 ENSMUSG00000024639 Gnaq / P21279 / guanine nucleotide binding protein, alpha q polypeptide / P50148* / G protein subunit alpha q*  / reaction / complex
 ENSMUSG00000024386 Proc / P33587 / Vitamin K-dependent protein C Vitamin K-dependent protein C light chain Vitamin K-dependent protein C heavy chain Activation peptide / P04070* / protein C, inactivator of co...  / reaction / complex






 

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