ENSMUSG00000051314


Mus musculus

Features
Gene ID: ENSMUSG00000051314
  
Biological name :Ffar2
  
Synonyms : Ffar2 / Free fatty acid receptor 2 / Q8VCK6
  
Possible biological names infered from orthology : O15552
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B1
Gene start: 30818348
Gene end: 30823775
  
Corresponding Affymetrix probe sets: 10562117 (MoGene1.0st)   1425215_at (Mouse Genome 430 2.0 Array)   1425216_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000140215
Ensembl peptide - ENSMUSP00000129398
Ensembl peptide - ENSMUSP00000140484
Ensembl peptide - ENSMUSP00000140493
Ensembl peptide - ENSMUSP00000052600
Ensembl peptide - ENSMUSP00000127758
NCBI entrez gene - 233079     See in Manteia.
MGI - MGI:2441731
RefSeq - XM_011250554
RefSeq - NM_001168509
RefSeq - NM_001168510
RefSeq - NM_001168511
RefSeq - NM_001168512
RefSeq - NM_146187
RefSeq - XM_011250548
RefSeq - XM_011250549
RefSeq - XM_011250552
RefSeq - XM_011250553
RefSeq Peptide - NP_001161982
RefSeq Peptide - NP_001161983
RefSeq Peptide - NP_001161984
RefSeq Peptide - NP_666299
RefSeq Peptide - NP_001161981
swissprot - A0A087WR60
swissprot - Q8VCK6
swissprot - A0A087WQJ1
swissprot - A0A087WR67
Ensembl - ENSMUSG00000051314
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CU855821.1ENSDARG00000079661Danio rerio
 si:ch211-231m23.4ENSDARG00000041292Danio rerio
 si:ch73-90p23.1ENSDARG00000097901Danio rerio
 si:dkey-211g8.6ENSDARG00000063088Danio rerio
 si:dkey-211g8.7ENSDARG00000058535Danio rerio
 FFAR2ENSG00000126262Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ffar3 / Q3UFD7 / Free fatty acid receptor 3 / GPR42* / O14843* / O15529* / G protein-coupled receptor 42 (gene/pseudogene)*ENSMUSG0000001942941
Ffar1 / Q76JU9 / Free fatty acid receptor 1 / O14842*ENSMUSG0000004445325
Gpr4 / Q8BUD0 / G-protein coupled receptor 4 / P46093*ENSMUSG0000004431724
F2rl3 / O88634 / Proteinase-activated receptor 4 / Q96RI0* / F2R like thrombin or trypsin receptor 3*ENSMUSG0000005014722
F2r / P30558 / Proteinase-activated receptor 1 / P25116* / coagulation factor II thrombin receptor*ENSMUSG0000004837622
F2rl1 / P55086 / Proteinase-activated receptor 2 / P55085* / F2R like trypsin receptor 1*ENSMUSG0000002167822
F2rl2 / O08675 / Proteinase-activated receptor 3 / O00254* / coagulation factor II thrombin receptor like 2*ENSMUSG0000002167520
Gpr68 / Q8BFQ3 / Ovarian cancer G-protein coupled receptor 1 / Q15743* / G protein-coupled receptor 68*ENSMUSG0000004741519
Gpr65 / G protein-coupled receptor 65 / Q8IYL9*ENSMUSG0000002188619
Gpr132 / Q9Z282 / G protein-coupled receptor 132 / Q9UNW8*ENSMUSG0000002129818


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR013312  G protein-coupled receptor 40-related receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002232 leukocyte chemotaxis involved in inflammatory response IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002385 mucosal immune response IMP
 biological_processGO:0002673 regulation of acute inflammatory response IMP
 biological_processGO:0002720 positive regulation of cytokine production involved in immune response IMP
 biological_processGO:0002752 cell surface pattern recognition receptor signaling pathway ISO
 biological_processGO:0002879 positive regulation of acute inflammatory response to non-antigenic stimulus IMP
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway ISO
 biological_processGO:0019915 lipid storage IMP
 biological_processGO:0032722 positive regulation of chemokine production IMP
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0045444 fat cell differentiation IMP
 biological_processGO:0071398 cellular response to fatty acid ISO
 biological_processGO:0090276 regulation of peptide hormone secretion IMP
 biological_processGO:2000484 positive regulation of interleukin-8 secretion ISS
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity ISO
 molecular_functionGO:0008289 lipid binding IEA


Pathways (from Reactome)
Pathway description
G alpha (q) signalling events
Free fatty acid receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ntf3tm1Esm/Ntf3tm1Esm,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Ntf3tm1Esm/Ntf3tm1Esm,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Ntf3tm1Esm/Ntf3tm1Esm,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0001553 abnormal circulating free fatty acids level "anomalous blood concentrations of organic, monobasic acids derived from hydrocarbons and which are complexed with serum albumin for transport; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nfasctm1.1Brp/Nfasctm1.1Brp,Tg(Nefl-Nfasc)1Brp/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Ntf3tm1Esm/Ntf3tm1Esm,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Aplntm1Tq/Y
Genetic Background: B6.129S6-Aplntm1Tq

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+,Ptentm2Mak/Ptentm2Mak,Tg(RasE)290Biat/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Ffar2tm2Soff/Ffar2tm2Soff,Ffar3tm2.1Soff/Ffar3tm2.1Soff,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

 MP:0002462 abnormal granulocyte physiology "functional anomaly of neutrophils, eosinophils, or basophils " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Aplntm1Tq/Y
Genetic Background: B6.129S6-Aplntm1Tq

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Aplntm1Tq/Y
Genetic Background: B6.129S6-Aplntm1Tq

 MP:0002467 impaired neutrophil phagocytosis "reduced ability of these leukocytes to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Aplntm1Tq/Y
Genetic Background: B6.129S6-Aplntm1Tq

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ffar2tm2Soff/Ffar2tm2Soff,Ffar3tm2.1Soff/Ffar3tm2.1Soff,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm2Sbn/Traf3ip2tm2Sbn,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0003293 rectal hemorrhage "bleeding in the rectum" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Ntf3tm1Esm/Ntf3tm1Esm,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0003304 large intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the large intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Ntf3tm1Esm/Ntf3tm1Esm,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0003564 abnormal insulin secretion "aberrant release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ffar2tm2Soff/Ffar2tm2Soff,Ffar3tm2.1Soff/Ffar3tm2.1Soff,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

 MP:0003724 susceptibility to induced arthritis "more likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Aplntm1Tq/Y
Genetic Background: B6.129S6-Aplntm1Tq

 MP:0003866 abnormal defecation "anomaly in the production and excretion of feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ntf3tm1Esm/Ntf3tm1Esm,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Aplntm1Tq/Y
Genetic Background: B6.129S6-Aplntm1Tq

 MP:0005044 sepsis "presence of various pathogenic organisms, or their toxins, in the blood or tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:82434]
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Allelic Composition: Ntf3tm1Esm/Ntf3tm1Esm,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0005065 abnormal neutrophil morphology "structural anomaly of the granular leukocytes that have a three- to five-lobed nucleus and a cytoplasm that contains inconspicuous granules stainable by neutral dyes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ntf3tm1Esm/Ntf3tm1Esm,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ffar2tm2Soff/Ffar2tm2Soff,Ffar3tm2.1Soff/Ffar3tm2.1Soff,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm2Sbn/Traf3ip2tm2Sbn,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Aplntm1Tq/Y
Genetic Background: B6.129S6-Aplntm1Tq

 MP:0008539 decreased susceptibility to induced colitis "decreased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ntf3tm1Esm/Ntf3tm1Esm,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Ntf3tm1Esm/Ntf3tm1Esm,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0008554 decreased circulating tumor necrosis factor level "reduction in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Ntf3tm1Esm/Ntf3tm1Esm,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Ntf3tm1Esm/Ntf3tm1Esm,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ntf3tm1Esm/Ntf3tm1Esm,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0008720 impaired neutrophil migration "defect in the ability of neutrophils to move along a chemotactic gradient" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Aplntm1Tq/Y
Genetic Background: B6.129S6-Aplntm1Tq

Allelic Composition: Ffar2tm2Lex/Ffar2tm2Lex
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Aplntm1Tq/Y
Genetic Background: B6.129S6-Aplntm1Tq

Allelic Composition: Ffar2tm2Lex/Ffar2tm2Lex
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010155 abnormal intestine physiology "any functional anomaly of the digestive tube passing from the stomach to the anus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm2Sbn/Traf3ip2tm2Sbn,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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