ENSMUSG00000019429


Mus musculus

Features
Gene ID: ENSMUSG00000019429
  
Biological name :Ffar3
  
Synonyms : Ffar3 / Free fatty acid receptor 3 / Q3UFD7
  
Possible biological names infered from orthology : GPR42 / G protein-coupled receptor 42 (gene/pseudogene) / O14843 / O15529
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B1
Gene start: 30854330
Gene end: 30856178
  
Corresponding Affymetrix probe sets: 10562125 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000092163
Ensembl peptide - ENSMUSP00000140252
NCBI entrez gene - 233080     See in Manteia.
MGI - MGI:2685324
RefSeq - NM_001033316
RefSeq Peptide - NP_001028488
swissprot - Q08AU6
swissprot - Q3UFD7
Ensembl - ENSMUSG00000019429
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CU855821.1ENSDARG00000079661Danio rerio
 si:ch211-231m23.4ENSDARG00000041292Danio rerio
 si:ch73-90p23.1ENSDARG00000097901Danio rerio
 si:dkey-211g8.6ENSDARG00000063088Danio rerio
 si:dkey-211g8.7ENSDARG00000058535Danio rerio
 FFAR3ENSG00000185897Homo sapiens
 GPR42ENSG00000126251Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ffar2 / Q8VCK6 / Free fatty acid receptor 2 / O15552*ENSMUSG0000005131442
Ffar1 / Q76JU9 / Free fatty acid receptor 1 / O14842*ENSMUSG0000004445328
F2rl1 / P55086 / Proteinase-activated receptor 2 / P55085* / F2R like trypsin receptor 1*ENSMUSG0000002167826
F2r / P30558 / Proteinase-activated receptor 1 / P25116* / coagulation factor II thrombin receptor*ENSMUSG0000004837626
F2rl3 / O88634 / Proteinase-activated receptor 4 / Q96RI0* / F2R like thrombin or trypsin receptor 3*ENSMUSG0000005014724
Gpr68 / Q8BFQ3 / Ovarian cancer G-protein coupled receptor 1 / Q15743* / G protein-coupled receptor 68*ENSMUSG0000004741521
Gpr4 / Q8BUD0 / G-protein coupled receptor 4 / P46093*ENSMUSG0000004431721
Gpr65 / G protein-coupled receptor 65 / Q8IYL9*ENSMUSG0000002188621
F2rl2 / O08675 / Proteinase-activated receptor 3 / O00254* / coagulation factor II thrombin receptor like 2*ENSMUSG0000002167520
Gpr132 / Q9Z282 / G protein-coupled receptor 132 / Q9UNW8*ENSMUSG0000002129818


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR013312  G protein-coupled receptor 40-related receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002385 mucosal immune response IMP
 biological_processGO:0002720 positive regulation of cytokine production involved in immune response IMP
 biological_processGO:0002879 positive regulation of acute inflammatory response to non-antigenic stimulus IMP
 biological_processGO:0003062 regulation of heart rate by chemical signal IMP
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway ISO
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway ISS
 biological_processGO:0032722 positive regulation of chemokine production IMP
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0045760 positive regulation of action potential IMP
 biological_processGO:0045776 negative regulation of blood pressure IMP
 biological_processGO:0046885 regulation of hormone biosynthetic process IMP
 biological_processGO:0071398 cellular response to fatty acid ISO
 biological_processGO:0090276 regulation of peptide hormone secretion IMP
 biological_processGO:2001275 positive regulation of glucose import in response to insulin stimulus IMP
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity ISO
 molecular_functionGO:0008289 lipid binding IEA


Pathways (from Reactome)
Pathway description
G alpha (q) signalling events
Free fatty acid receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001015 small superior cervical ganglion "reduced size of the group of neurons that is the largest of the ganglia of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck" [J:23882]
Show

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Pax1un-ex/Pax1un-ex
Genetic Background: Not Specified

 MP:0001629 abnormal heart rate "greater than or fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001664 abnormal digestion "altered ability of the mechanical, chemical, and enzymatic processes of the body to convert ingested food into material suitable for assimiliation for synthesis of tissues or liberation of energy " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pax1un-ex/Pax1un-ex
Genetic Background: Not Specified

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+,Ptentm2Mak/Ptentm2Mak,Tg(RasE)290Biat/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Ffar2tm2Soff/Ffar2tm2Soff,Ffar3tm2.1Soff/Ffar3tm2.1Soff,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

 MP:0002575 increased circulating ketone body level "greater than the normal amount of acetoacetate, 3-hydroxybutyrate and acteone in the blood; produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, J:71968]
Show

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ffar2tm2Soff/Ffar2tm2Soff,Ffar3tm2.1Soff/Ffar3tm2.1Soff,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

 MP:0003564 abnormal insulin secretion "aberrant release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ffar2tm2Soff/Ffar2tm2Soff,Ffar3tm2.1Soff/Ffar3tm2.1Soff,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

 MP:0003868 abnormal feces composition "increase or decrease in the amount of compunds normally found in the feces (fat, protein etc) or presence of material not normally seen in the feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pax1un-ex/Pax1un-ex
Genetic Background: Not Specified

 MP:0003964 abnormal noradrenaline level "aberrant concentration of this precursor of epinephrine that is a widespread central and autonomic neurotransmitter" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0005288 abnormal oxygen consumption "deviation from the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ffar2tm2Soff/Ffar2tm2Soff,Ffar3tm2.1Soff/Ffar3tm2.1Soff,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm2Sbn/Traf3ip2tm2Sbn,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0005318 decreased triglyceride level "lower than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pax1un-ex/Pax1un-ex
Genetic Background: Not Specified

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
Show

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0005448 abnormal energy balance "aberrant intake or expenditure of calories as compared to the normal state" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pax1un-ex/Pax1un-ex
Genetic Background: Not Specified

 MP:0005534 decreased body temperature "less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0005664 decreased circulating noradrenaline level "less than the normal blood concentration of this precursor of epinephrine that is a widespread central and autonomic neurotransmitter" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0005666 abnormal adipose tissue physiology "functional anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Rnf8Gt(AS0574)Wtsi/Rnf8+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Pax1un-ex/Pax1un-ex
Genetic Background: Not Specified

 MP:0006001 abnormal intestinal transit time "increase or decrease in the time it takes for a bolus of material to pass through the intestine" [smb:Susan M Bello, Mouse Genome Iformatics Curator]
Show

Allelic Composition: Pax1un-ex/Pax1un-ex
Genetic Background: Not Specified

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0009253 abnormal sympathetic neuron physiology "any functional anomaly of any of the neurons of the part of the autonomic nervous system that innervates smooth muscle, cardiac muscle and glands and mediates the body s response to stressful situations" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0009284 abnormal sympathetic neuron innervation "defective or incomplete supply of nerve fibers to sympathetic termini" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0009289 decreased epididymal fat pad weight 
Show

Allelic Composition: Pax1un-ex/Pax1un-ex
Genetic Background: Not Specified

 MP:0010155 abnormal intestine physiology "any functional anomaly of the digestive tube passing from the stomach to the anus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Traf3ip2tm2Sbn/Traf3ip2tm2Sbn,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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