ENSMUSG00000044317


Mus musculus

Features
Gene ID: ENSMUSG00000044317
  
Biological name :Gpr4
  
Synonyms : Gpr4 / G-protein coupled receptor 4 / Q8BUD0
  
Possible biological names infered from orthology : P46093
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: A3
Gene start: 19212538
Gene end: 19224174
  
Corresponding Affymetrix probe sets: 10550627 (MoGene1.0st)   1457745_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000061243
NCBI entrez gene - 319197     See in Manteia.
MGI - MGI:2441992
RefSeq - NM_175668
RefSeq - XM_006540048
RefSeq Peptide - NP_783599
swissprot - Q8BUD0
Ensembl - ENSMUSG00000044317
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gpr4ENSDARG00000079479Danio rerio
 GPR4ENSG00000177464Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gpr68 / Q8BFQ3 / Ovarian cancer G-protein coupled receptor 1 / Q15743* / G protein-coupled receptor 68*ENSMUSG0000004741544
Gpr65 / G protein-coupled receptor 65 / Q8IYL9*ENSMUSG0000002188633
Gpr132 / Q9Z282 / G protein-coupled receptor 132 / Q9UNW8*ENSMUSG0000002129832
F2rl1 / P55086 / Proteinase-activated receptor 2 / P55085* / F2R like trypsin receptor 1*ENSMUSG0000002167824
Ffar2 / Q8VCK6 / Free fatty acid receptor 2 / O15552*ENSMUSG0000005131422
F2rl3 / O88634 / Proteinase-activated receptor 4 / Q96RI0* / F2R like thrombin or trypsin receptor 3*ENSMUSG0000005014722
F2r / P30558 / Proteinase-activated receptor 1 / P25116* / coagulation factor II thrombin receptor*ENSMUSG0000004837621
F2rl2 / O08675 / Proteinase-activated receptor 3 / O00254* / coagulation factor II thrombin receptor like 2*ENSMUSG0000002167520
Ffar3 / Q3UFD7 / Free fatty acid receptor 3 / GPR42* / O14843* / O15529* / G protein-coupled receptor 42 (gene/pseudogene)*ENSMUSG0000001942919
Ffar1 / Q76JU9 / Free fatty acid receptor 1 / O14842*ENSMUSG0000004445317


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR002276  G protein-coupled receptor 4 orphan
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IMP
 biological_processGO:0010447 response to acidic pH IMP
 biological_processGO:0016525 negative regulation of angiogenesis IMP
 biological_processGO:0035025 positive regulation of Rho protein signal transduction IBA
 biological_processGO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IBA
 biological_processGO:0060055 angiogenesis involved in wound healing IDA
 biological_processGO:0072144 glomerular mesangial cell development IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IMP


Pathways (from Reactome)
Pathway description
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Faddtm1Mpa/Faddtm1Mpa,Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0000525 renal tubular acidosis "a clinical syndrome characterized by the inability to acidify urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19268]
Show

Allelic Composition: Piezo1tm2.1Apat/Piezo1tm2.1Apat,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA

 MP:0000533 kidney hemorrhage "bleeding in the organ of excretion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Faddtm1Mpa/Faddtm1Mpa,Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0001182 lung hemorrhage "bleeding in the respiratory organs" [J:66345]
Show

Allelic Composition: Faddtm1Mpa/Faddtm1Mpa,Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Faddtm1Mpa/Faddtm1Mpa,Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Faddtm1Mpa/Faddtm1Mpa,Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Faddtm1Mpa/Faddtm1Mpa,Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Faddtm1Mpa/Faddtm1Mpa,Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0001957 apnea "absence of breathing; sometimes episodic" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17384]
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Allelic Composition: Piezo1tm2.1Apat/Piezo1tm2.1Apat,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA

 MP:0002318 hypercapnia "elevated concentration of CO2 in the blood, alveoli or other tissues resulting in the increased pressure of this component of body gases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Piezo1tm2.1Apat/Piezo1tm2.1Apat,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA

 MP:0002901 hyperphosphaturia "an increase of excretion of phosphates in the urine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Piezo1tm2.1Apat/Piezo1tm2.1Apat,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA

 MP:0002986 hypocalciuria "excretion of abnormally low amounts of calcium in the urine" [J:83000]
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Allelic Composition: Piezo1tm2.1Apat/Piezo1tm2.1Apat,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA

 MP:0003031 acidosis "a pathological state characterized by an increase in the hydrogen ion concentration of arterial blood; caused by an decrease in the concentration of alkaline compounds, or by a increase in the concentration of acidic compounds or carbon dioxide to the body fluids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Piezo1tm2.1Apat/Piezo1tm2.1Apat,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
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Allelic Composition: Piezo1tm2.1Apat/Piezo1tm2.1Apat,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA

 MP:0003477 abnormal nerve fiber response "anomaly in the electrophysiological recordings from a single or several nerve fiber(s)" [Nmice:Neuromice Consortium Submission]
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Allelic Composition: Piezo1tm2.1Apat/Piezo1tm2.1Apat,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA

 MP:0003620 decreased urine output "decreased volume of urine produced and excreted" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Piezo1tm2.1Apat/Piezo1tm2.1Apat,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faddtm1Mpa/Faddtm1Mpa,Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0005435 hemoperitoneum "blood in the peritoneal cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87293]
Show

Allelic Composition: Faddtm1Mpa/Faddtm1Mpa,Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0005488 bronchial epithelial hyperplasia "increased numbers of cells lining the inner surfaces of the bronchi" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Faddtm1Mpa/Faddtm1Mpa,Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0005576 decreased pulmonary ventilation "less than the normal total volume of gas per minute inspired or expired " [RGD:Rat Genome Database submission]
Show

Allelic Composition: Piezo1tm2.1Apat/Piezo1tm2.1Apat,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA

 MP:0005592 abnormal vascular smooth muscle morphology "structural anomaly of the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faddtm1Mpa/Faddtm1Mpa,Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Piezo1tm2.1Apat/Piezo1tm2.1Apat,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA

 MP:0008055 increased urine osmolality "increase in the concentration of ions in the urine compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Piezo1tm2.1Apat/Piezo1tm2.1Apat,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA

 MP:0008816 petechiae "very small blood spots or splotches that appear especially in skin as a result of localized hemorrhage" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Faddtm1Mpa/Faddtm1Mpa,Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0010144 abnormal tumor vascularization "aberrant process of blood vessel formation and the subsequent remodeling process within and/or around tumors" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Piezo1tm2.1Apat/Piezo1tm2.1Apat,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Faddtm1Mpa/Faddtm1Mpa,Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Faddtm1Mpa/Faddtm1Mpa,Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0011428 mesangial cell hypoplasia "decreased number of the phagocytic cells in the capillary tuft of the renal glomerulus, interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft" [MGI:anna]
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Allelic Composition: Faddtm1Mpa/Faddtm1Mpa,Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0011437 glomerulus hemorrhage "bleeding in the renal glomerulus" [MGI:anna]
Show

Allelic Composition: Faddtm1Mpa/Faddtm1Mpa,Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0011470 increased urine creatinine level "an increased amount of creatinine in the urine compared to the normal state" [MGI:csmith]
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Allelic Composition: Piezo1tm2.1Apat/Piezo1tm2.1Apat,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA

 MP:0011735 increased urine ammonia level "a greater amount of ammonia in the urine compared to the normal state" [MGI:anna]
Show

Allelic Composition: Piezo1tm2.1Apat/Piezo1tm2.1Apat,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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