Manteia

ENSMUSG00000021675

Mus musculus

Features

Gene ID:	ENSMUSG00000021675

Biological name :	F2rl2

Synonyms :	F2rl2 / O08675 / Proteinase-activated receptor 3

Possible biological names infered from orthology :	coagulation factor II thrombin receptor like 2 / O00254

Species:	Mus musculus

Chr. number:	13
Strand:	1
Band:	D1
Gene start:	95696853
Gene end:	95702739

Corresponding Affymetrix probe sets:	10406736 (MoGene1.0st) 1421407_at (Mouse Genome 430 2.0 Array) 1445680_x_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000022182 NCBI entrez gene - 14064 See in Manteia. MGI - MGI:1298208 RefSeq - NM_010170 RefSeq Peptide - NP_034300 swissprot - O08675 Ensembl - ENSMUSG00000021675

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
CABZ01071020.1	ENSDARG00000079472	Danio rerio
f2rl2	ENSDARG00000090524	Danio rerio
F2RL2	ENSGALG00000023379	Gallus gallus
F2RL2	ENSG00000164220	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
F2rl1 / P55086 / Proteinase-activated receptor 2 / P55085* / F2R like trypsin receptor 1*	ENSMUSG00000021678	30
F2r / P30558 / Proteinase-activated receptor 1 / P25116* / coagulation factor II thrombin receptor*	ENSMUSG00000048376	27
F2rl3 / O88634 / Proteinase-activated receptor 4 / Q96RI0* / F2R like thrombin or trypsin receptor 3*	ENSMUSG00000050147	26
Gpr4 / Q8BUD0 / G-protein coupled receptor 4 / P46093*	ENSMUSG00000044317	20
Gpr68 / Q8BFQ3 / Ovarian cancer G-protein coupled receptor 1 / Q15743* / G protein-coupled receptor 68*	ENSMUSG00000047415	20
Gpr65 / G protein-coupled receptor 65 / Q8IYL9*	ENSMUSG00000021886	19
Gpr132 / Q9Z282 / G protein-coupled receptor 132 / Q9UNW8*	ENSMUSG00000021298	19
Ffar2 / Q8VCK6 / Free fatty acid receptor 2 / O15552*	ENSMUSG00000051314	18
Ffar3 / Q3UFD7 / Free fatty acid receptor 3 / GPR42* / O14843* / O15529* / G protein-coupled receptor 42 (gene/pseudogene)*	ENSMUSG00000019429	17
Ffar1 / Q76JU9 / Free fatty acid receptor 1 / O14842*	ENSMUSG00000044453	15

Protein motifs (from Interpro)

Interpro ID	Name
IPR000276	G protein-coupled receptor, rhodopsin-like
IPR003912	Protease-activated receptor
IPR003943	Protease-activated receptor 3
IPR017452	GPCR, rhodopsin-like, 7TM

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0007165	signal transduction	IEA
biological_process	GO:0007186	G-protein coupled receptor signaling pathway	IEA
biological_process	GO:0007596	blood coagulation	IEA
biological_process	GO:0007599	hemostasis	IEA
biological_process	GO:0035025	positive regulation of Rho protein signal transduction	IBA
biological_process	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway	IBA
biological_process	GO:0070493	thrombin-activated receptor signaling pathway	IEA
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0005887	integral component of plasma membrane	IBA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0016324	apical plasma membrane	IDA
cellular_component	GO:0032991	protein-containing complex	IEA
molecular_function	GO:0004871	obsolete signal transducer activity	IEA
molecular_function	GO:0004930	G-protein coupled receptor activity	IBA
molecular_function	GO:0015057	thrombin-activated receptor activity	IEA

Pathways (from Reactome)

Pathway description

Peptide ligand-binding receptors

G alpha (q) signalling events

Thrombin signalling through proteinase activated receptors (PARs)

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0005048	thrombosis	"formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Frem1^heb/Frem1^heb Genetic Background: AKR/J
MP:0005464	abnormal platelet physiology	"atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Frem1^heb/Frem1^heb Genetic Background: AKR/J
MP:0005606	increased bleeding time	"greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]	Show Allelic Composition: Frem1^heb/Frem1^heb Genetic Background: AKR/J

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000000149	Gna12 / P27600 / guanine nucleotide binding protein, alpha 12 / Q03113* / G protein subunit alpha 12*	/ complex / reaction
ENSMUSG00000020611	Gna13 / P27601 / guanine nucleotide binding protein, alpha 13 / Q14344* / G protein subunit alpha 13*	/ complex / reaction
ENSMUSG00000021675	F2rl2 / O08675 / Proteinase-activated receptor 3 / O00254* / coagulation factor II thrombin receptor like 2*	/ reaction
ENSMUSG00000024639	Gnaq / P21279 / guanine nucleotide binding protein, alpha q polypeptide / P50148* / G protein subunit alpha q*	/ reaction / complex
ENSMUSG00000034781	Gna11 / P21278 / guanine nucleotide binding protein, alpha 11 / P29992* / G protein subunit alpha 11*	/ complex / reaction
ENSMUSG00000034792	Gna15 / P30678 / guanine nucleotide binding protein, alpha 15 / P30679* / G protein subunit alpha 15*	/ complex / reaction
ENSMUSG00000029064	Gnb1 / P62874 / guanine nucleotide binding protein (G protein), beta 1 / P62873* / G protein subunit beta 1*	/ reaction / complex
ENSMUSG00000043004	Gng2 / P63213 / guanine nucleotide binding protein (G protein), gamma 2 / P59768* / G protein subunit gamma 2*	/ complex / reaction
ENSMUSG00000050147	F2rl3 / O88634 / Proteinase-activated receptor 4 / Q96RI0* / F2R like thrombin or trypsin receptor 3*	/ reaction
ENSMUSG00000048376	F2r / P30558 / Proteinase-activated receptor 1 / P25116* / coagulation factor II thrombin receptor*	/ reaction
ENSMUSG00000024697	Gna14 / P30677 / guanine nucleotide binding protein, alpha 14 / O95837* / G protein subunit alpha 14*	/ complex / reaction
ENSMUSG00000027249	F2 / P19221 / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain / P00734* / coagulation factor II, thrombin*	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr