ENSMUSG00000044453


Mus musculus

Features
Gene ID: ENSMUSG00000044453
  
Biological name :Ffar1
  
Synonyms : Ffar1 / Free fatty acid receptor 1 / Q76JU9
  
Possible biological names infered from orthology : O14842
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B1
Gene start: 30857390
Gene end: 30861564
  
Corresponding Affymetrix probe sets: 10562130 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000055564
NCBI entrez gene - 233081     See in Manteia.
MGI - MGI:2684079
RefSeq - NM_194057
RefSeq Peptide - NP_918946
swissprot - Q76JU9
Ensembl - ENSMUSG00000044453
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:dkey-211g8.9ENSDARG00000087828Danio rerio
 FFAR1ENSG00000126266Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ffar3 / Q3UFD7 / Free fatty acid receptor 3 / GPR42* / O14843* / O15529* / G protein-coupled receptor 42 (gene/pseudogene)*ENSMUSG0000001942930
Ffar2 / Q8VCK6 / Free fatty acid receptor 2 / O15552*ENSMUSG0000005131427
F2rl3 / O88634 / Proteinase-activated receptor 4 / Q96RI0* / F2R like thrombin or trypsin receptor 3*ENSMUSG0000005014722
Gpr4 / Q8BUD0 / G-protein coupled receptor 4 / P46093*ENSMUSG0000004431721
F2rl1 / P55086 / Proteinase-activated receptor 2 / P55085* / F2R like trypsin receptor 1*ENSMUSG0000002167821
Gpr68 / Q8BFQ3 / Ovarian cancer G-protein coupled receptor 1 / Q15743* / G protein-coupled receptor 68*ENSMUSG0000004741520
F2r / P30558 / Proteinase-activated receptor 1 / P25116* / coagulation factor II thrombin receptor*ENSMUSG0000004837620
F2rl2 / O08675 / Proteinase-activated receptor 3 / O00254* / coagulation factor II thrombin receptor like 2*ENSMUSG0000002167519
Gpr65 / G protein-coupled receptor 65 / Q8IYL9*ENSMUSG0000002188618
Gpr132 / Q9Z282 / G protein-coupled receptor 132 / Q9UNW8*ENSMUSG0000002129818


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR013312  G protein-coupled receptor 40-related receptor
 IPR013313  GPR40 receptor fatty acid
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0030073 insulin secretion IMP
 biological_processGO:0032024 positive regulation of insulin secretion IMP
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0051928 positive regulation of calcium ion transport IEA
 biological_processGO:0070542 response to fatty acid IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0045125 bioactive lipid receptor activity IDA


Pathways (from Reactome)
Pathway description
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
G alpha (q) signalling events
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
Free fatty acid receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000187 abnormal triglyceride level "anomalous concentration of this molecule, glycerol esterified at each of its three hydroxyl groups by a fatty acid; triglyceride is an important molecule for storage of fatty acids in adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Foxp3tm4(YFP/icre)Ayr/Foxp3tm4(YFP/icre)Ayr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ffar1tm1Dgen/Ffar1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Emx1tm1.1(KOMP)Vlcg/Emx1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Emx1tm1.1(KOMP)Vlcg/Ucd

 MP:0001560 abnormal circulating insulin level "anomalous blood concentration of this polypeptide hormone, secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Myh11tm2Peri/Myh11tm2Peri
Genetic Background: involves: 129 * C57BL/6

 MP:0001985 abnormal gustatory system physiology "anomalous perception of taste" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ndufs4tm1.1Rpa/Ndufs4tm1.1Rpa
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001986 taste sensitivity/ preferences 
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Allelic Composition: Ndufs4tm1.1Rpa/Ndufs4tm1.1Rpa
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002059 abnormal seminal gland morphology "anomalous structure of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Emx1tm1.1(KOMP)Vlcg/Emx1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Emx1tm1.1(KOMP)Vlcg/Ucd

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Foxp3tm4(YFP/icre)Ayr/Foxp3tm4(YFP/icre)Ayr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ffar1tm1Dgen/Ffar1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002696 decreased circulating glucagon level "lower than normal blood concentration of this peptide hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ffar1tm1Dgen/Ffar1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Foxp3tm4(YFP/icre)Ayr/Foxp3tm4(YFP/icre)Ayr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Foxp3tm4(YFP/icre)Ayr/Foxp3tm4(YFP/icre)Ayr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Sirt1tm1.1Ygu/Sirt1tm1.1Ygu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

Allelic Composition: Ffar1tm1Heed/Ffar1tm1Heed
Genetic Background: Not Specified

 MP:0003383 abnormal gluconeogenesis "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]
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Allelic Composition: Ffar1tm1Heed/Ffar1tm1Heed
Genetic Background: Not Specified

 MP:0003565 abnormal glucagon secretion "anomaly in the release of this hormone secreted by the alpha cells of the islets of Langerhans; it normally plays a role in regulation of blood glucose concentration, ketone metabolism, and other biochemical and physiological processes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Rc3h2tm1c(KOMP)Wtsi/Rc3h2tm1c(KOMP)Wtsi,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: C57BL/6N * DBA/2

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Foxp3tm4(YFP/icre)Ayr/Foxp3tm4(YFP/icre)Ayr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005418 abnormal circulating hormone level "anomalous blood concentration of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs; originally applied to substances secreted by various endocrine glands and transported in the bloodstream to the target organs, it is sometimes extended to include substances that are not produced by the endocrine glands but that have similar effects" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ffar1tm1Dgen/Ffar1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Rc3h1tm1.1Mass/Rc3h1tm1.1Mass,Rc3h2tm1c(KOMP)Wtsi/Rc3h2tm1c(KOMP)Wtsi,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: C57BL/6N * DBA/2

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ffar1tm1Dgen/Ffar1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010055 abnormal sensory neuron physiology "any functional anomaly of cells that innervate an effector (muscle or glandular) tissue and are responsible for transmission of sensory impulses" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ndufs4tm1.1Rpa/Ndufs4tm1.1Rpa
Genetic Background: involves: 129S4/SvJaeSor

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Ffar1tm1Dgen/Ffar1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0014125 decreased amylin secretion "reduction in the production or release of the polypeptide hormone that is normally co-secreted with insulin by the beta cells of the pancreatic islets of Langerhans and is known to inhibit glucagon secretion, delay gastric emptying, and act as a satiety agent" [http://www.ajpcr.com/Vol6Issue1/1462.pdf]
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Allelic Composition: Ffar1tm1Dgen/Ffar1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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