ENSMUSG00000047415


Mus musculus

Features
Gene ID: ENSMUSG00000047415
  
Biological name :Gpr68
  
Synonyms : Gpr68 / Ovarian cancer G-protein coupled receptor 1 / Q8BFQ3
  
Possible biological names infered from orthology : G protein-coupled receptor 68 / Q15743
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: E
Gene start: 100876682
Gene end: 100908198
  
Corresponding Affymetrix probe sets: 10402136 (MoGene1.0st)   10402140 (MoGene1.0st)   1455000_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000057510
Ensembl peptide - ENSMUSP00000105692
Ensembl peptide - ENSMUSP00000105693
NCBI entrez gene - 238377     See in Manteia.
MGI - MGI:2441763
RefSeq - XM_017315062
RefSeq - NM_001177673
RefSeq - NM_001177674
RefSeq - NM_175493
RefSeq Peptide - NP_001171145
RefSeq Peptide - NP_780702
RefSeq Peptide - NP_001171144
swissprot - Q8BFQ3
Ensembl - ENSMUSG00000047415
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GPR68ENSDARG00000053711Danio rerio
 GPR68ENSGALG00000010707Gallus gallus
 GPR68ENSG00000119714Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gpr4 / Q8BUD0 / G-protein coupled receptor 4 / P46093*ENSMUSG0000004431744
Gpr65 / G protein-coupled receptor 65 / Q8IYL9*ENSMUSG0000002188631
Gpr132 / Q9Z282 / G protein-coupled receptor 132 / Q9UNW8*ENSMUSG0000002129827
F2r / P30558 / Proteinase-activated receptor 1 / P25116* / coagulation factor II thrombin receptor*ENSMUSG0000004837622
F2rl1 / P55086 / Proteinase-activated receptor 2 / P55085* / F2R like trypsin receptor 1*ENSMUSG0000002167822
F2rl3 / O88634 / Proteinase-activated receptor 4 / Q96RI0* / F2R like thrombin or trypsin receptor 3*ENSMUSG0000005014721
F2rl2 / O08675 / Proteinase-activated receptor 3 / O00254* / coagulation factor II thrombin receptor like 2*ENSMUSG0000002167521
Ffar3 / Q3UFD7 / Free fatty acid receptor 3 / GPR42* / O14843* / O15529* / G protein-coupled receptor 42 (gene/pseudogene)*ENSMUSG0000001942919
Ffar2 / Q8VCK6 / Free fatty acid receptor 2 / O15552*ENSMUSG0000005131418
Ffar1 / Q76JU9 / Free fatty acid receptor 1 / O14842*ENSMUSG0000004445316


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR005389  OGR1 sphingosylphosphorylcholine receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0032024 positive regulation of insulin secretion IMP
 biological_processGO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
 biological_processGO:0045656 negative regulation of monocyte differentiation IMP
 biological_processGO:0071467 cellular response to pH IMP
 biological_processGO:2001206 positive regulation of osteoclast development IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA


Pathways (from Reactome)
Pathway description
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000005 increased brown fat amount "increased amount of thermogenic tissue in the body that is composed of cells containing multiple small fat droplets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:14208]
Show

Allelic Composition: Npc1m1N/Npc1m1N,Tg(CAG-RAB9A)500Repa/0
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gpr68tm1.1Yaxu/Gpr68tm1.1Yaxu
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gpr68tm1Yaxu/Gpr68tm1Yaxu
Genetic Background: involves: C57BL/6

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
Show

Allelic Composition: Npc1m1N/Npc1m1N,Tg(CAG-RAB9A)500Repa/0
Genetic Background: involves: BALB/c * C57BL/6 * CBA

Allelic Composition: Gpr68tm1.1Yaxu/Gpr68tm1.1Yaxu
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

Allelic Composition: Gpr68tm1Yaxu/Gpr68tm1Yaxu
Genetic Background: involves: C57BL/6

 MP:0001780 decreased brown fat amount "reduced quantity of this thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gpr68tm1.1Yaxu/Gpr68tm1.1Yaxu
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Syne2cpfl8/Syne2cpfl8
Genetic Background: B6.Cg-Syne2cpfl8

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gpr68tm1.1Yaxu/Gpr68tm1.1Yaxu
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

Allelic Composition: Gpr68tm1Yaxu/Gpr68tm1Yaxu
Genetic Background: involves: C57BL/6

 MP:0002696 decreased circulating glucagon level "lower than normal blood concentration of this peptide hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Htr1btm1Rhn/Htr1b+,Tph1tm1Kry/Tph1+,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Htr1btm1Rhn/Htr1b+,Tph1tm1Kry/Tph1+,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Gpr68tm1.1Aha/Gpr68tm1.1Aha
Genetic Background: B6.129(C)-Gpr68tm1.1Aha

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Htr1btm1Rhn/Htr1b+,Tph1tm1Kry/Tph1+,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0002971 abnormal brown fat morphology "defect in the thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gpr68tm1.1Yaxu/Gpr68tm1.1Yaxu
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

Allelic Composition: Gpr68tm1Yaxu/Gpr68tm1Yaxu
Genetic Background: involves: C57BL/6

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Htr1btm1Rhn/Htr1b+,Tph1tm1Kry/Tph1+,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Gpr68tm1.1Aha/Gpr68tm1.1Aha
Genetic Background: B6.129(C)-Gpr68tm1.1Aha

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
Show

Allelic Composition: Npc1m1N/Npc1m1N,Tg(CAG-RAB9A)500Repa/0
Genetic Background: involves: BALB/c * C57BL/6 * CBA

Allelic Composition: Gpr68tm1.1Yaxu/Gpr68tm1.1Yaxu
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0003721 increased tumor growth/size "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gpr68tm1Yaxu/Gpr68tm1Yaxu
Genetic Background: involves: C57BL/6

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
Show

Allelic Composition: Gpr68tm1.1Yaxu/Gpr68tm1.1Yaxu
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Htr1btm1Rhn/Htr1b+,Tph1tm1Kry/Tph1+,Tg(Vil-cre)20Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Npc1m1N/Npc1m1N,Tg(CAG-RAB9A)500Repa/0
Genetic Background: involves: BALB/c * C57BL/6 * CBA

Allelic Composition: Gpr68tm1.1Yaxu/Gpr68tm1.1Yaxu
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

Allelic Composition: Gpr68tm1Yaxu/Gpr68tm1Yaxu
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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