ENSMUSG00000021298


Mus musculus

Features
Gene ID: ENSMUSG00000021298
  
Biological name :Gpr132
  
Synonyms : Gpr132 / G protein-coupled receptor 132 / Q9Z282
  
Possible biological names infered from orthology : Q9UNW8
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: F1
Gene start: 112850873
Gene end: 112868228
  
Corresponding Affymetrix probe sets: 10402800 (MoGene1.0st)   1421755_at (Mouse Genome 430 2.0 Array)   1444233_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021729
Ensembl peptide - ENSMUSP00000152509
NCBI entrez gene - 56696     See in Manteia.
MGI - MGI:1890220
RefSeq - XM_006516103
RefSeq - NM_019925
RefSeq - XM_006516102
RefSeq Peptide - NP_064309
swissprot - Q9Z282
swissprot - A0A1Y7VNN0
Ensembl - ENSMUSG00000021298
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gpr132aENSDARG00000021497Danio rerio
 gpr132bENSDARG00000103540Danio rerio
 GPR132ENSGALG00000027407Gallus gallus
 GPR132ENSG00000183484Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gpr4 / Q8BUD0 / G-protein coupled receptor 4 / P46093*ENSMUSG0000004431730
Gpr68 / Q8BFQ3 / Ovarian cancer G-protein coupled receptor 1 / Q15743* / G protein-coupled receptor 68*ENSMUSG0000004741526
Gpr65 / G protein-coupled receptor 65 / Q8IYL9*ENSMUSG0000002188624
F2rl1 / P55086 / Proteinase-activated receptor 2 / P55085* / F2R like trypsin receptor 1*ENSMUSG0000002167821
F2r / P30558 / Proteinase-activated receptor 1 / P25116* / coagulation factor II thrombin receptor*ENSMUSG0000004837620
F2rl2 / O08675 / Proteinase-activated receptor 3 / O00254* / coagulation factor II thrombin receptor like 2*ENSMUSG0000002167518
F2rl3 / O88634 / Proteinase-activated receptor 4 / Q96RI0* / F2R like thrombin or trypsin receptor 3*ENSMUSG0000005014718
Ffar3 / Q3UFD7 / Free fatty acid receptor 3 / GPR42* / O14843* / O15529* / G protein-coupled receptor 42 (gene/pseudogene)*ENSMUSG0000001942915
Ffar2 / Q8VCK6 / Free fatty acid receptor 2 / O15552*ENSMUSG0000005131415
Ffar1 / Q76JU9 / Free fatty acid receptor 1 / O14842*ENSMUSG0000004445314


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR005388  G2A lysophosphatidylcholine receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IDA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0010972 negative regulation of G2/M transition of mitotic cell cycle IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity ISS


Pathways (from Reactome)
Pathway description
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dnase1tm1Tmo/Dnase1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dnase1tm1Tmo/Dnase1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001859 kidney inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Dnase1tm1Tmo/Dnase1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Dnase1tm1Tmo/Dnase1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Dnase1tm1Tmo/Dnase1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002339 abnormal lymph node morphology "anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Dnase1tm1Tmo/Dnase1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002461 increased circulating immunoglobulin concentration "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dnase1tm1Tmo/Dnase1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dnase1tm1Tmo/Dnase1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dnase1tm1Tmo/Dnase1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003799 impaired macrophage migration "defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Atrnmg/Atrnmg
Genetic Background: LDJ/Le

 MP:0003945 abnormal lymphocyte physiology "abnormal function of any of the white blood cells that includes B cells, T cells, and NK cells " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dnase1tm1Tmo/Dnase1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dnase1tm1Tmo/Dnase1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dnase1tm1Tmo/Dnase1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dnase1tm1Tmo/Dnase1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005338 atherosclerotic lesions "thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Dnase1tm1Tmo/Dnase1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dnase1tm1Tmo/Dnase1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dnase1tm1Tmo/Dnase1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009623 enlarged inguinal lymph nodes "increased size of the lymph nodes located in the groin area" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dnase1tm1Tmo/Dnase1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011081 decreased macrophage apoptosis "reduced incidence of cell death in macrophages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gpr132tm1Witt/Gpr132tm1Witt,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.129-Ldlrtm1Her Gpr132tm1Witt

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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