ENSMUSG00000021678


Mus musculus

Features
Gene ID: ENSMUSG00000021678
  
Biological name :F2rl1
  
Synonyms : F2rl1 / P55086 / Proteinase-activated receptor 2
  
Possible biological names infered from orthology : F2R like trypsin receptor 1 / P55085
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: D1
Gene start: 95511732
Gene end: 95525227
  
Corresponding Affymetrix probe sets: 10411226 (MoGene1.0st)   1448931_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022185
NCBI entrez gene - 14063     See in Manteia.
MGI - MGI:101910
RefSeq - NM_007974
RefSeq Peptide - NP_032000
swissprot - P55086
swissprot - Q3TU81
Ensembl - ENSMUSG00000021678
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 f2rl1.1ENSDARG00000068856Danio rerio
 f2rl1.2ENSDARG00000077540Danio rerio
 F2RL1ENSGALG00000014984Gallus gallus
 F2RL1ENSG00000164251Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
F2r / P30558 / Proteinase-activated receptor 1 / P25116* / coagulation factor II thrombin receptor*ENSMUSG0000004837632
F2rl3 / O88634 / Proteinase-activated receptor 4 / Q96RI0* / F2R like thrombin or trypsin receptor 3*ENSMUSG0000005014729
F2rl2 / O08675 / Proteinase-activated receptor 3 / O00254* / coagulation factor II thrombin receptor like 2*ENSMUSG0000002167528
Gpr4 / Q8BUD0 / G-protein coupled receptor 4 / P46093*ENSMUSG0000004431722
Ffar3 / Q3UFD7 / Free fatty acid receptor 3 / GPR42* / O14843* / O15529* / G protein-coupled receptor 42 (gene/pseudogene)*ENSMUSG0000001942921
Gpr65 / G protein-coupled receptor 65 / Q8IYL9*ENSMUSG0000002188621
Gpr68 / Q8BFQ3 / Ovarian cancer G-protein coupled receptor 1 / Q15743* / G protein-coupled receptor 68*ENSMUSG0000004741521
Gpr132 / Q9Z282 / G protein-coupled receptor 132 / Q9UNW8*ENSMUSG0000002129820
Ffar2 / Q8VCK6 / Free fatty acid receptor 2 / O15552*ENSMUSG0000005131418
Ffar1 / Q76JU9 / Free fatty acid receptor 1 / O14842*ENSMUSG0000004445316


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR002281  Protease-activated receptor 2
 IPR003912  Protease-activated receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002286 T cell activation involved in immune response IDA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002690 positive regulation of leukocyte chemotaxis IEA
 biological_processGO:0002741 positive regulation of cytokine secretion involved in immune response IEA
 biological_processGO:0003104 positive regulation of glomerular filtration IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway ISO
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007596 blood coagulation IEA
 biological_processGO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IDA
 biological_processGO:0030193 regulation of blood coagulation IEA
 biological_processGO:0030335 positive regulation of cell migration IDA
 biological_processGO:0030836 positive regulation of actin filament depolymerization IEA
 biological_processGO:0031274 positive regulation of pseudopodium assembly IDA
 biological_processGO:0032930 positive regulation of superoxide anion generation IEA
 biological_processGO:0034137 positive regulation of toll-like receptor 2 signaling pathway IEA
 biological_processGO:0034140 negative regulation of toll-like receptor 3 signaling pathway IEA
 biological_processGO:0034141 positive regulation of toll-like receptor 3 signaling pathway IEA
 biological_processGO:0034145 positive regulation of toll-like receptor 4 signaling pathway IEA
 biological_processGO:0035025 positive regulation of Rho protein signal transduction IEA
 biological_processGO:0035926 chemokine (C-C motif) ligand 2 secretion IEA
 biological_processGO:0042119 neutrophil activation IEA
 biological_processGO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043311 positive regulation of eosinophil degranulation IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045217 cell-cell junction maintenance IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046328 regulation of JNK cascade IEA
 biological_processGO:0046329 negative regulation of JNK cascade IEA
 biological_processGO:0046330 positive regulation of JNK cascade IEA
 biological_processGO:0050702 interleukin-1 beta secretion IEA
 biological_processGO:0050900 leukocyte migration IEA
 biological_processGO:0050921 positive regulation of chemotaxis IDA
 biological_processGO:0050927 positive regulation of positive chemotaxis IEA
 biological_processGO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IBA
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0060100 positive regulation of phagocytosis, engulfment IEA
 biological_processGO:0061028 establishment of endothelial barrier IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070493 thrombin-activated receptor signaling pathway IEA
 biological_processGO:0070661 leukocyte proliferation IDA
 biological_processGO:0070963 positive regulation of neutrophil mediated killing of gram-negative bacterium IEA
 biological_processGO:0072608 interleukin-10 secretion IEA
 biological_processGO:0072643 interferon-gamma secretion IDA
 biological_processGO:0090195 chemokine secretion IDA
 biological_processGO:0090198 negative regulation of chemokine secretion IEA
 biological_processGO:0097029 mature conventional dendritic cell differentiation IDA
 biological_processGO:0097755 positive regulation of blood vessel diameter IMP
 biological_processGO:1900135 positive regulation of renin secretion into blood stream IDA
 biological_processGO:2000484 positive regulation of interleukin-8 secretion IEA
 biological_processGO:2000778 positive regulation of interleukin-6 secretion IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031143 pseudopodium IDA
 molecular_functionGO:0001965 G-protein alpha-subunit binding IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity ISO
 molecular_functionGO:0015057 thrombin-activated receptor activity IEA
 molecular_functionGO:0031681 G-protein beta-subunit binding IDA
 molecular_functionGO:0032795 heterotrimeric G-protein binding TAS


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000230 abnormal blood pressure "altered tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tacr1tm1Sph/Tacr1tm1Sph
Genetic Background: involves: 129P2/OlaHsd

 MP:0000565 oligodactyly "congenital condition in which some digits or parts of digits are missing" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Eya4tm1b(KOMP)Wtsi/Eya4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Eya4tm1b(KOMP)Wtsi/Tcp

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: F2rtm1.1Cgh/F2rtm1.1Cgh,F2rl1tm2Cgh/F2rl1tm2Cgh,Tg(Tek-F2r)1Cgh/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: F2rl1tm1Cgh/F2rl1tm1Cgh,Spint2Gt(KST272)Byg/Spint2Gt(KST272)Byg,St14tm1Bug/St14+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
Show

Allelic Composition: Fbn2fp/Fbn2mz
Genetic Background: involves: BALB/cAnNCrl * C3H/HeH * C3HeB/FeHu * C57BL/6J

 MP:0001240 abnormal cornified layer morphology "structural or developmental anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: F2rl1tm1Cgh/F2rl1tm1Cgh,Spink5tm1Hov/Spink5tm1Hov
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
Show

Allelic Composition: F2rl1tm1Cgh/F2rl1tm1Cgh,Spink5tm1Hov/Spink5tm1Hov
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
Show

Allelic Composition: Eya4tm1b(KOMP)Wtsi/Eya4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Eya4tm1b(KOMP)Wtsi/Tcp

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lcattm1Nsa/Lcat+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Tc/th51,Tg(T)118.9Bgh/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0001874 acanthosis "diffuse hyperplasia of the spinous layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: F2rl1tm1Cgh/F2rl1tm1Cgh,Spink5tm1Hov/Spink5tm1Hov
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lcattm1Nsa/Lcat+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: F2rl1tm1Mslb/F2rl1tm1Mslb
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001883 mammary adenocarcinoma "higher than normal incidence of malignant tumors of the mammary gland" [J:62919]
Show

Allelic Composition: T/twPas2
Genetic Background: involves: M. m. brevirostris

 MP:0001970 abnormal pain threshold "increased or decreased average level of perception of pain" [J:17792]
Show

Allelic Composition: Lcattm1Nsa/Lcat+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
Show

Allelic Composition: Acanb2b183Clo/Acanb2b183Clo
Genetic Background: C57BL/6J-Acanb2b183Clo

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: F2rl1tm1Mslb/F2rl1tm1Mslb
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002098 abnormal vibrissae morphology "irregular or unusual structure, appearance, or alignment of the vibrissae" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Acanb2b183Clo/Acanb2b183Clo
Genetic Background: C57BL/6J-Acanb2b183Clo

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prss8fr/Prss8+,Spint2Gt(KST272)Byg/Spint2Gt(KST272)Byg
Genetic Background: involves: 129P2/OlaHsd * DBA

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: F2rl1tm1Mslb/F2rl1tm1Mslb
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002733 abnormal thermal nociception "abnormal capability to sense pain elicited by thermal stimulation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: F2rl1tm1Mslb/F2rl1tm1Mslb
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003051 curly tail "a loop or corkscrew-like curl in the tail" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Prss8fr/Prss8+,Spint2Gt(KST272)Byg/Spint2Gt(KST272)Byg
Genetic Background: involves: 129P2/OlaHsd * DBA

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: F2rtm1Ajc/F2rtm1Ajc,F2rl1tm1Cgh/F2rl1tm1Cgh
Genetic Background: involves: 129S4/SvJae

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
Show

Allelic Composition: Tc/th51,Tg(T)118.9Bgh/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0004761 susceptibility to induced pancreatitis "more likely than normal to develop an inflammatory response, or an increased inflammatory response in the pancreatic tissue after experimental manipulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lcattm1Nsa/Lcat+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0005085 abnormal gall bladder physiology "anomalous action or function of the organ that stores and concentrates bile " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: F2rl1tm1Mslb/F2rl1tm1Mslb
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: F2rl1tm1Mslb/F2rl1tm1Mslb
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: F2rl1tm1Mslb/F2rl1tm1Mslb
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005501 abnormal skin physiology "atypical function of the membranous protective covering of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: F2rl1tm1Mslb/F2rl1tm1Mslb
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005616 decreased susceptibility to type IV hypersensitivity reaction "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ppp1r1btm2Pggd/Ppp1r1btm2Pggd
Genetic Background: involves: 129 * C57BL/6

 MP:0006060 increased cerebral infarction size "increased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tc/th51,Tg(T)118.9Bgh/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0008127 decreased dendritic cell number "reduction in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tc/T+,Tg(T)118.9Bgh/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0008636 decreased circulating interleukin-18 level "reduction in the amount in the blood of a cytokine which enhances the cytotoxic activity of NK cells and cytotoxic T-cells and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity" [MESH:D12.644.276.374.465.518]
Show

Allelic Composition: Tc/th51,Tg(T)118.9Bgh/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: F3tm1Dco/F3tm1Dco,Tg(F3)1Nmk/0
Genetic Background: B6.Cg-F3tm1Dco Tg(F3)1Nmk

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tc/T+,Tg(T)118.9Bgh/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0008762 embryonic lethality "death of an animal in the embryonic period (Mus: up to E14)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tc/T+,Tg(T)118.9Bgh/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tc/T+,Tg(T)118.9Bgh/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tc/th51,Tg(T)118.9Bgh/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tc/th51,Tg(T)118.9Bgh/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Eya4tm1b(KOMP)Wtsi/Eya4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Eya4tm1b(KOMP)Wtsi/Tcp

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tc/T+,Tg(T)118.9Bgh/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0010144 abnormal tumor vascularization "aberrant process of blood vessel formation and the subsequent remodeling process within and/or around tumors" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
Show

Allelic Composition: T/twPas2
Genetic Background: involves: M. m. brevirostris

 MP:0010269 decreased mammary gland tumor incidence "less than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: T/twPas2
Genetic Background: involves: M. m. brevirostris

 MP:0010383 increased adenoma incidence "greater than the expected number of a benign epithelial neoplasm with a glandular organization, occurring in a specific population in a given time period; this tumor type usually does not invade or infiltrate surrounding tissue but may remain a benign tumor or progress to malignancy" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:C04.557.470.035]
Show

Allelic Composition: T/twPas2
Genetic Background: involves: M. m. brevirostris

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Tacr1tm1Sph/Tacr1tm1Sph
Genetic Background: involves: 129P2/OlaHsd

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: F2rl1tm1Cgh/F2rl1tm1Cgh,Spink5tm1Hov/Spink5tm1Hov
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Tacr1tm1Sph/Tacr1tm1Sph
Genetic Background: involves: 129P2/OlaHsd

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: F2rl1tm1Cgh/F2rl1tm1Cgh,Spint2Gt(KST272)Byg/Spint2Gt(KST272)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0011102 partial embryonic lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Tc/T+,Tg(T)118.9Bgh/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0020332 impaired leukocyte tethering or rolling "reduced ability or inability in the transient adhesive interactions between leukocytes and endothelial cells lining blood vessels mediated primarily by selectins and which are typically the first step in cellular extravasation" [GO:0050901, ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: F2rl1tm1Mslb/F2rl1tm1Mslb
Genetic Background: involves: 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027249 F2 / P19221 / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain / P00734* / coagulation factor II, thrombin*  / complex / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr