ENSG00000119714


Homo sapiens

Features
Gene ID: ENSG00000119714
  
Biological name :GPR68
  
Synonyms : GPR68 / G protein-coupled receptor 68 / Q15743
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: -1
Band: q32.11
Gene start: 91232532
Gene end: 91253925
  
Corresponding Affymetrix probe sets: 211249_at (Human Genome U133 Plus 2.0 Array)   229055_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000440797
Ensembl peptide - ENSP00000432740
Ensembl peptide - ENSP00000434045
NCBI entrez gene - 8111     See in Manteia.
OMIM - 601404
RefSeq - XM_011537199
RefSeq - NM_001177676
RefSeq - NM_003485
RefSeq - XM_005268112
RefSeq - XM_006720262
RefSeq - XM_011537196
RefSeq - XM_011537197
RefSeq - XM_011537198
RefSeq - XM_005268110
RefSeq - XM_005268111
RefSeq Peptide - NP_001171147
RefSeq Peptide - NP_001335366
RefSeq Peptide - NP_003476
swissprot - Q15743
swissprot - E9PNU7
Ensembl - ENSG00000119714
  
Related genetic diseases (OMIM): 617217 - Amelogenesis imperfecta, hypomaturation type, IIA6, 617217
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GPR68ENSDARG00000053711Danio rerio
 GPR68ENSGALG00000010707Gallus gallus
 Gpr68ENSMUSG00000047415Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GPR4 / P46093 / G protein-coupled receptor 4ENSG0000017746446
GPR65 / Q8IYL9 / G protein-coupled receptor 65ENSG0000014003032
GPR132 / Q9UNW8 / G protein-coupled receptor 132ENSG0000018348426
F2R / P25116 / coagulation factor II thrombin receptorENSG0000018110422
F2RL1 / P55085 / F2R like trypsin receptor 1ENSG0000016425122
F2RL2 / O00254 / coagulation factor II thrombin receptor like 2ENSG0000016422022
F2RL3 / Q96RI0 / F2R like thrombin or trypsin receptor 3ENSG0000012753321
P2RY8 / Q86VZ1 / P2Y receptor family member 8ENSG0000018216220
FFAR3 / O14843 / free fatty acid receptor 3ENSG0000018589719
GPR42 / O15529 / G protein-coupled receptor 42 (gene/pseudogene)ENSG0000012625119
FFAR2 / O15552 / free fatty acid receptor 2ENSG0000012626218
FFAR1 / O14842 / free fatty acid receptor 1ENSG0000012626618


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR005389  OGR1 sphingosylphosphorylcholine receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0032024 positive regulation of insulin secretion IEA
 biological_processGO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA
 biological_processGO:0045656 negative regulation of monocyte differentiation IEA
 biological_processGO:0071467 cellular response to pH IEA
 biological_processGO:2001206 positive regulation of osteoclast development IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity TAS


Pathways (from Reactome)
Pathway description
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000007 Autosomal recessive inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
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 HP:0200095 Anterior open bite 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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