ENSG00000181104


Homo sapiens

Features
Gene ID: ENSG00000181104
  
Biological name :F2R
  
Synonyms : coagulation factor II thrombin receptor / F2R / P25116
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q13.3
Gene start: 76716043
Gene end: 76735781
  
Corresponding Affymetrix probe sets: 1569642_at (Human Genome U133 Plus 2.0 Array)   203989_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000426398
Ensembl peptide - ENSP00000321326
NCBI entrez gene - 2149     See in Manteia.
OMIM - 187930
RefSeq - NM_001992
RefSeq - NM_001311313
RefSeq Peptide - NP_001298242
RefSeq Peptide - NP_001983
swissprot - P25116
swissprot - A0A024RAP7
swissprot - G3XAL6
Ensembl - ENSG00000181104
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 f2rENSDARG00000060012Danio rerio
 F2RENSGALG00000014983Gallus gallus
 F2rENSMUSG00000048376Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
F2RL1 / P55085 / F2R like trypsin receptor 1ENSG0000016425132
F2RL2 / O00254 / coagulation factor II thrombin receptor like 2ENSG0000016422027
F2RL3 / Q96RI0 / F2R like thrombin or trypsin receptor 3ENSG0000012753327
P2RY8 / Q86VZ1 / P2Y receptor family member 8ENSG0000018216226
GPR132 / Q9UNW8 / G protein-coupled receptor 132ENSG0000018348421
GPR42 / O15529 / G protein-coupled receptor 42 (gene/pseudogene)ENSG0000012625120
FFAR3 / O14843 / free fatty acid receptor 3ENSG0000018589720
GPR65 / Q8IYL9 / G protein-coupled receptor 65ENSG0000014003019
GPR68 / Q15743 / G protein-coupled receptor 68ENSG0000011971419
FFAR2 / O15552 / free fatty acid receptor 2ENSG0000012626218
GPR4 / P46093 / G protein-coupled receptor 4ENSG0000017746417
FFAR1 / O14842 / free fatty acid receptor 1ENSG0000012626615


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000935  Thrombin receptor
 IPR003912  Protease-activated receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000186 activation of MAPKK activity ISS
 biological_processGO:0002248 connective tissue replacement involved in inflammatory response wound healing IDA
 biological_processGO:0003105 negative regulation of glomerular filtration ISS
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration ISS
 biological_processGO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway ISS
 biological_processGO:0007529 establishment of synaptic specificity at neuromuscular junction ISS
 biological_processGO:0007596 blood coagulation TAS
 biological_processGO:0007599 hemostasis IEA
 biological_processGO:0008284 positive regulation of cell proliferation ISS
 biological_processGO:0008285 negative regulation of cell proliferation IDA
 biological_processGO:0009611 response to wounding IDA
 biological_processGO:0009653 anatomical structure morphogenesis TAS
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling ISS
 biological_processGO:0030168 platelet activation IDA
 biological_processGO:0030193 regulation of blood coagulation IDA
 biological_processGO:0030194 positive regulation of blood coagulation IDA
 biological_processGO:0030335 positive regulation of cell migration IMP
 biological_processGO:0032496 response to lipopolysaccharide ISS
 biological_processGO:0032651 regulation of interleukin-1 beta production ISS
 biological_processGO:0032967 positive regulation of collagen biosynthetic process IDA
 biological_processGO:0035025 positive regulation of Rho protein signal transduction ISS
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEP
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0043410 positive regulation of MAPK cascade IDA
 biological_processGO:0043524 negative regulation of neuron apoptotic process ISS
 biological_processGO:0043547 positive regulation of GTPase activity IMP
 biological_processGO:0045217 cell-cell junction maintenance IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045907 positive regulation of vasoconstriction ISS
 biological_processGO:0045987 positive regulation of smooth muscle contraction ISS
 biological_processGO:0048873 homeostasis of number of cells within a tissue ISS
 biological_processGO:0051209 release of sequestered calcium ion into cytosol ISS
 biological_processGO:0051281 positive regulation of release of sequestered calcium ion into cytosol IDA
 biological_processGO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway ISS
 biological_processGO:0051928 positive regulation of calcium ion transport ISS
 biological_processGO:0051930 regulation of sensory perception of pain ISS
 biological_processGO:0060155 platelet dense granule organization IC
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade ISS
 biological_processGO:0070493 thrombin-activated receptor signaling pathway IEA
 biological_processGO:0099553 trans-synaptic signaling by endocannabinoid, modulating synaptic transmission IEA
 biological_processGO:1900134 negative regulation of renin secretion into blood stream ISS
 biological_processGO:2000484 positive regulation of interleukin-8 secretion IDA
 biological_processGO:2000778 positive regulation of interleukin-6 secretion IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0005769 early endosome IDA
 cellular_componentGO:0005770 late endosome IDA
 cellular_componentGO:0005794 Golgi apparatus TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0005901 caveola IDA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031094 platelet dense tubular network IDA
 cellular_componentGO:0031594 neuromuscular junction ISS
 cellular_componentGO:0045211 postsynaptic membrane ISS
 molecular_functionGO:0001965 G-protein alpha-subunit binding ISS
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity TAS
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015057 thrombin-activated receptor activity IDA
 molecular_functionGO:0031681 G-protein beta-subunit binding ISS


Pathways (from Reactome)
Pathway description
Common Pathway of Fibrin Clot Formation
Peptide ligand-binding receptors
G alpha (q) signalling events
Thrombin signalling through proteinase activated receptors (PARs)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000088256 GNA11 / P29992 / G protein subunit alpha 11  / complex / reaction
 ENSG00000100030 MAPK1 / P28482 / mitogen-activated protein kinase 1  / complex / reaction
 ENSG00000127533 F2RL3 / Q96RI0 / F2R like thrombin or trypsin receptor 3  / reaction
 ENSG00000060558 GNA15 / P30679 / G protein subunit alpha 15  / reaction / complex
 ENSG00000102882 MAPK3 / P27361 / mitogen-activated protein kinase 3  / complex / reaction
 ENSG00000156052 GNAQ / P50148 / G protein subunit alpha q  / reaction / complex
 ENSG00000164220 F2RL2 / O00254 / coagulation factor II thrombin receptor like 2  / reaction
 ENSG00000146535 GNA12 / Q03113 / G protein subunit alpha 12  / reaction / complex
 ENSG00000180210 F2 / P00734 / coagulation factor II, thrombin  / reaction / complex
 ENSG00000078369 GNB1 / P62873 / G protein subunit beta 1  / reaction / complex
 ENSG00000137486 ARRB1 / P49407 / arrestin beta 1  / reaction / complex
 ENSG00000120063 GNA13 / Q14344 / G protein subunit alpha 13  / complex / reaction
 ENSG00000101000 PROCR / Q9UNN8 / protein C receptor  / complex / reaction
 ENSG00000181104 F2R / P25116 / coagulation factor II thrombin receptor  / reaction
 ENSG00000141480 ARRB2 / P32121 / arrestin beta 2  / reaction / complex
 ENSG00000186469 GNG2 / P59768 / G protein subunit gamma 2  / complex / reaction
 ENSG00000156049 GNA14 / O95837 / G protein subunit alpha 14  / complex / reaction
 ENSG00000115718 PROC / P04070 / protein C, inactivator of coagulation factors Va and VIIIa  / complex / reaction
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / reaction / complex






 

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