ENSG00000060558


Homo sapiens

Features
Gene ID: ENSG00000060558
  
Biological name :GNA15
  
Synonyms : GNA15 / G protein subunit alpha 15 / P30679
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: p13.3
Gene start: 3136193
Gene end: 3163769
  
Corresponding Affymetrix probe sets: 205349_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000262958
Ensembl peptide - ENSP00000467256
NCBI entrez gene - 2769     See in Manteia.
OMIM - 139314
RefSeq - NM_002068
RefSeq Peptide - NP_002059
swissprot - P30679
swissprot - K7EP74
Ensembl - ENSG00000060558
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gna15.1ENSDARG00000016364Danio rerio
 gna15.2ENSDARG00000056654Danio rerio
 Gna15ENSMUSG00000034792Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GNA11 / P29992 / G protein subunit alpha 11ENSG0000008825654
GNAQ / P50148 / G protein subunit alpha qENSG0000015605254
GNA14 / O95837 / G protein subunit alpha 14ENSG0000015604953
GNAO1 / P09471 / G protein subunit alpha o1ENSG0000008725843
GNAT1 / P11488 / G protein subunit alpha transducin 1ENSG0000011434942
GNAI2 / P04899 / G protein subunit alpha i2ENSG0000011435341
GNAT3 / A8MTJ3 / G protein subunit alpha transducin 3ENSG0000021441541
GNAI3 / P08754 / G protein subunit alpha i3ENSG0000006513541
GNAI1 / P63096 / G protein subunit alpha i1ENSG0000012795541
GNAT2 / P19087 / G protein subunit alpha transducin 2ENSG0000013418341
GNAZ / P19086 / G protein subunit alpha zENSG0000012826640
GNA13 / Q14344 / G protein subunit alpha 13ENSG0000012006339
GNA12 / Q03113 / G protein subunit alpha 12ENSG0000014653537


Protein motifs (from Interpro)
Interpro ID Name
 IPR000654  G-protein alpha subunit, group Q
 IPR001019  Guanine nucleotide binding protein (G-protein), alpha subunit
 IPR011025  G protein alpha subunit, helical insertion
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IBA
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007202 activation of phospholipase C activity TAS
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007207 phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway TAS
 biological_processGO:0030168 platelet activation TAS
 biological_processGO:0060158 phospholipase C-activating dopamine receptor signaling pathway IBA
 cellular_componentGO:0005834 heterotrimeric G-protein complex NAS
 cellular_componentGO:0005886 plasma membrane TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IBA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019001 guanyl nucleotide binding IEA
 molecular_functionGO:0031683 G-protein beta/gamma-subunit complex binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Acetylcholine regulates insulin secretion
G alpha (q) signalling events
ADP signalling through P2Y purinoceptor 1
Thromboxane signalling through TP receptor
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
Thrombin signalling through proteinase activated receptors (PARs)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000127533 F2RL3 / Q96RI0 / F2R like thrombin or trypsin receptor 3  / reaction / complex
 ENSG00000240771 Q86VW2 / ARHGEF25 / Rho guanine nucleotide exchange factor 25  / reaction / complex
 ENSG00000198873 GRK5 / P34947 / G protein-coupled receptor kinase 5  / reaction / complex
 ENSG00000182621 PLCB1 / Q9NQ66 / phospholipase C beta 1  / reaction / complex
 ENSG00000121879 P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha  / reaction / complex
 ENSG00000137841 PLCB2 / Q00722 / phospholipase C beta 2  / complex / reaction
 ENSG00000164220 F2RL2 / O00254 / coagulation factor II thrombin receptor like 2  / reaction / complex
 ENSG00000186469 GNG2 / P59768 / G protein subunit gamma 2  / complex / reaction
 ENSG00000173020 GRK2 / P25098 / G protein-coupled receptor kinase 2  / complex / reaction
 ENSG00000038382 TRIO / O75962 / trio Rho guanine nucleotide exchange factor  / reaction / complex
 ENSG00000149782 PLCB3 / Q01970 / phospholipase C beta 3  / complex / reaction
 ENSG00000101333 PLCB4 / Q15147 / phospholipase C beta 4  / reaction / complex
 ENSG00000145675 P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1  / complex / reaction
 ENSG00000078369 GNB1 / P62873 / G protein subunit beta 1  / complex / reaction
 ENSG00000160145 KALRN / O60229 / kalirin RhoGEF kinase  / reaction / complex
 ENSG00000169860 P2RY1 / P47900 / purinergic receptor P2Y1  / reaction / complex
 ENSG00000006638 P21731 / TBXA2R / thromboxane A2 receptor  / reaction / complex
 ENSG00000181104 F2R / P25116 / coagulation factor II thrombin receptor  / reaction / complex






 

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