ENSG00000240771


Homo sapiens

Features
Gene ID: ENSG00000240771
  
Biological name :ARHGEF25
  
Synonyms : ARHGEF25 / Q86VW2 / Rho guanine nucleotide exchange factor 25
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q13.3
Gene start: 57610180
Gene end: 57619379
  
Corresponding Affymetrix probe sets: 227427_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000286494
Ensembl peptide - ENSP00000484303
Ensembl peptide - ENSP00000335560
NCBI entrez gene - 115557     See in Manteia.
OMIM - 610215
RefSeq - NM_001111270
RefSeq - NM_182947
RefSeq Peptide - NP_001104740
RefSeq Peptide - NP_891992
swissprot - A0A024RBA8
swissprot - Q86VW2
Ensembl - ENSG00000240771
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgef25bENSDARG00000014465Danio rerio
 BX539336.1ENSDARG00000100606Danio rerio
 Arhgef25ENSMUSG00000019467Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TRIO / O75962 / trio Rho guanine nucleotide exchange factorENSG0000003838250
MCF2L / O15068 / MCF.2 cell line derived transforming sequence likeENSG0000012621720
MCF2 / P10911 / MCF.2 cell line derived transforming sequenceENSG0000010197720
Q9ULL1 / PLEKHG1 / pleckstrin homology and RhoGEF domain containing G1ENSG0000012027819
A1L390 / PLEKHG3 / pleckstrin homology and RhoGEF domain containing G3ENSG0000012682219
Q9H7P9 / PLEKHG2 / pleckstrin homology and RhoGEF domain containing G2ENSG0000009092418
MCF2L2 / Q86YR7 / MCF.2 cell line derived transforming sequence-like 2ENSG0000005352416
KALRN / O60229 / kalirin RhoGEF kinaseENSG000001601455


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR030738  Rho guanine nucleotide exchange factor 25
 IPR035899  Dbl homology (DH) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030016 myofibril ISS
 cellular_componentGO:0030017 sarcomere IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA


Pathways (from Reactome)
Pathway description
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000088256 GNA11 / P29992 / G protein subunit alpha 11  / reaction / complex
 ENSG00000060558 GNA15 / P30679 / G protein subunit alpha 15  / reaction / complex
 ENSG00000156052 GNAQ / P50148 / G protein subunit alpha q  / reaction / complex
 ENSG00000156049 GNA14 / O95837 / G protein subunit alpha 14  / complex / reaction






 

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