ENSG00000101977


Homo sapiens

Features
Gene ID: ENSG00000101977
  
Biological name :MCF2
  
Synonyms : MCF2 / MCF.2 cell line derived transforming sequence / P10911
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: -1
Band: q27.1
Gene start: 139581770
Gene end: 139708227
  
Corresponding Affymetrix probe sets: 1555313_a_at (Human Genome U133 Plus 2.0 Array)   208017_s_at (Human Genome U133 Plus 2.0 Array)   214884_at (Human Genome U133 Plus 2.0 Array)   217004_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000438155
Ensembl peptide - ENSP00000427745
Ensembl peptide - ENSP00000430276
Ensembl peptide - ENSP00000342204
Ensembl peptide - ENSP00000359605
Ensembl peptide - ENSP00000359608
Ensembl peptide - ENSP00000397055
Ensembl peptide - ENSP00000403271
Ensembl peptide - ENSP00000405848
NCBI entrez gene - 4168     See in Manteia.
OMIM - 311030
RefSeq - XM_017029532
RefSeq - NM_001099855
RefSeq - NM_001171876
RefSeq - NM_001171877
RefSeq - NM_001171878
RefSeq - NM_001171879
RefSeq - NM_005369
RefSeq - XM_005262413
RefSeq - XM_011531339
RefSeq - XM_017029529
RefSeq - XM_017029530
RefSeq - XM_017029531
RefSeq Peptide - NP_001165350
RefSeq Peptide - NP_001165348
RefSeq Peptide - NP_001165349
RefSeq Peptide - NP_005360
RefSeq Peptide - NP_001093325
RefSeq Peptide - NP_001165347
swissprot - P10911
swissprot - Q5JYJ5
swissprot - H0Y662
Ensembl - ENSG00000101977
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mcf2aENSDARG00000022895Danio rerio
 mcf2bENSDARG00000056603Danio rerio
 MCF2ENSGALG00000006562Gallus gallus
 Mcf2ENSMUSG00000031139Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MCF2L / O15068 / MCF.2 cell line derived transforming sequence likeENSG0000012621745
MCF2L2 / Q86YR7 / MCF.2 cell line derived transforming sequence-like 2ENSG0000005352436
TRIO / O75962 / trio Rho guanine nucleotide exchange factorENSG0000003838228
Q9ULL1 / PLEKHG1 / pleckstrin homology and RhoGEF domain containing G1ENSG0000012027813
KALRN / O60229 / kalirin RhoGEF kinaseENSG0000016014513
A1L390 / PLEKHG3 / pleckstrin homology and RhoGEF domain containing G3ENSG0000012682212
Q86VW2 / ARHGEF25 / Rho guanine nucleotide exchange factor 25ENSG0000024077112
Q9H7P9 / PLEKHG2 / pleckstrin homology and RhoGEF domain containing G2ENSG0000009092411


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001251  CRAL-TRIO lipid binding domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR018159  Spectrin/alpha-actinin
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036865  CRAL-TRIO lipid binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043065 positive regulation of apoptotic process TAS
 biological_processGO:0050771 negative regulation of axonogenesis TAS
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton TAS
 cellular_componentGO:0016020 membrane TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Axonal growth inhibition (RHOA activation)
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000067560 RHOA / P61586 / ras homolog family member A  / reaction






 

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