ENSDARG00000022895


Danio rerio

Features
Gene ID: ENSDARG00000022895
  
Biological name :mcf2a
  
Synonyms : mcf2a / MCF.2 cell line derived transforming sequence a
  
Possible biological names infered from orthology : MCF2 / MCF.2 cell line derived transforming sequence / P10911
  
Species: Danio rerio
  
Chr. number: 14
Strand: -1
Band:
Gene start: 32440639
Gene end: 32503363
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000029313
Ensembl peptide - ENSDARP00000124326
Ensembl peptide - ENSDARP00000148352
Ensembl peptide - ENSDARP00000150853
NCBI entrez gene - 557201     See in Manteia.
RefSeq - XM_021472829
RefSeq - XM_680215
RefSeq - XM_005173226
RefSeq - XM_021472830
swissprot - F8W3Q6
swissprot - F1Q4X6
ZFIN ID - ZDB-GENE-030616-52
Ensembl - ENSDARG00000022895
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MCF2ENSGALG00000006562Gallus gallus
 MCF2ENSG00000101977Homo sapiens
 Mcf2ENSMUSG00000031139Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
mcf2b / MCF.2 cell line derived transforming sequence b / MCF2* / P10911* / MCF.2 cell line derived transforming sequence*ENSDARG0000005660353
mcf2la / mcf.2 cell line derived transforming sequence-like a / MCF2L* / O15068* / MCF.2 cell line derived transforming sequence like*ENSDARG0000007585946
mcf2l2 / MCF.2 cell line derived transforming sequence-like 2 / Q86YR7*ENSDARG0000007974244
mcf2lb / mcf.2 cell line derived transforming sequence-like b / MCF2L* / O15068* / MCF.2 cell line derived transforming sequence like*ENSDARG0000007648040
trioa / trio Rho guanine nucleotide exchange factor a / TRIO* / Q0KL02* / O75962* / Triple functional domain protein * / trio Rho guanine nucleotide exchange factor*ENSDARG0000001942626
triob / trio Rho guanine nucleotide exchange factor b / TRIO* / O75962* / trio Rho guanine nucleotide exchange factor*ENSDARG0000000037025
kalrna / kalirin RhoGEF kinase a / KALRN* / O60229* / A2CG49* / Kalirin * / kalirin RhoGEF kinase*ENSDARG0000010411923
plekhg2 / pleckstrin homology domain containing, family G (with RhoGef domain) member 2ENSDARG0000005845911
arhgef25b / Rho guanine nucleotide exchange factor (GEF) 25b / Q86VW2* / ARHGEF25* / Rho guanine nucleotide exchange factor 25* / Mus musculus Rho guanine nucleotide exchange factor (GEF) 2...ENSDARG0000001446511
kalrnb / kalirin RhoGEF kinase b / KALRN* / O60229* / A2CG49* / Kalirin * / kalirin RhoGEF kinase*ENSDARG0000006353811
BX539336.1 / Q86VW2* / ARHGEF25* / Rho guanine nucleotide exchange factor 25*ENSDARG0000010060610
CABZ01048666.1 / Q9ULL1* / PLEKHG1* / pleckstrin homology and RhoGEF domain containing G1*ENSDARG000001115856
si:ch73-212j7.3 / A1L390* / Q4VAC9* / PLEKHG3* / pleckstrin homology and RhoGEF domain containing G3* / Pleckstrin homology domain-containing family G member 3 *ENSDARG000000966134
FP015810.1 / KALRN* / O60229* / kalirin RhoGEF kinase*ENSDARG000001127492


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001251  CRAL-TRIO lipid binding domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001452  SH3 domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR035532  DBS, SH3 domain
 IPR035534  DBS, PH domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA


Pathways (from Reactome)
Pathway description
Axonal growth inhibition (RHOA activation)
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000094673 rhoab / Q6DHM9 / ras homolog gene family, member Ab / RHOA* / Q9QUI0* / P61586* / ras homolog family member A*  / reaction






 

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