ENSDARG00000019426


Danio rerio

Features
Gene ID: ENSDARG00000019426
  
Biological name :trioa
  
Synonyms : trioa / trio Rho guanine nucleotide exchange factor a
  
Possible biological names infered from orthology : O75962 / Q0KL02 / TRIO / trio Rho guanine nucleotide exchange factor / Triple functional domain protein
  
Species: Danio rerio
  
Chr. number: 19
Strand: -1
Band:
Gene start: 41841147
Gene end: 42045372
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000118025
Ensembl peptide - ENSDARP00000081489
NCBI entrez gene - 557667     See in Manteia.
RefSeq - XM_009294421
RefSeq - NM_001104526
RefSeq Peptide - NP_001097996
swissprot - J9JI09
swissprot - F1Q551
ZFIN ID - ZDB-GENE-060503-334
Ensembl - ENSDARG00000019426
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TRIOENSGALG00000031495Gallus gallus
 TRIOENSG00000038382Homo sapiens
 TrioENSMUSG00000022263Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
triob / trio Rho guanine nucleotide exchange factor b / TRIO* / O75962* / trio Rho guanine nucleotide exchange factor*ENSDARG0000000037079
kalrna / kalirin RhoGEF kinase a / KALRN* / O60229* / A2CG49* / Kalirin * / kalirin RhoGEF kinase*ENSDARG0000010411953
kalrnb / kalirin RhoGEF kinase b / KALRN* / O60229* / A2CG49* / Kalirin * / kalirin RhoGEF kinase*ENSDARG0000006353810
arhgef25b / Rho guanine nucleotide exchange factor (GEF) 25b / Q86VW2* / ARHGEF25* / Rho guanine nucleotide exchange factor 25* / Mus musculus Rho guanine nucleotide exchange factor (GEF) 2...ENSDARG0000001446510
mcf2l2 / MCF.2 cell line derived transforming sequence-like 2 / Q86YR7*ENSDARG0000007974210
mcf2la / mcf.2 cell line derived transforming sequence-like a / MCF2L* / O15068* / MCF.2 cell line derived transforming sequence like*ENSDARG000000758599
mcf2a / MCF.2 cell line derived transforming sequence a / MCF2* / P10911* / MCF.2 cell line derived transforming sequence*ENSDARG000000228959
BX539336.1 / Q86VW2* / ARHGEF25* / Rho guanine nucleotide exchange factor 25*ENSDARG000001006069
mcf2lb / mcf.2 cell line derived transforming sequence-like b / MCF2L* / O15068* / MCF.2 cell line derived transforming sequence like*ENSDARG000000764808
mcf2b / MCF.2 cell line derived transforming sequence b / MCF2* / P10911* / MCF.2 cell line derived transforming sequence*ENSDARG000000566037
FP015810.1 / KALRN* / O60229* / kalirin RhoGEF kinase*ENSDARG000001127496
plekhg2 / pleckstrin homology domain containing, family G (with RhoGef domain) member 2ENSDARG000000584595
CABZ01048666.1 / Q9ULL1* / PLEKHG1* / pleckstrin homology and RhoGEF domain containing G1*ENSDARG000001115852
si:ch73-212j7.3 / A1L390* / Q4VAC9* / PLEKHG3* / pleckstrin homology and RhoGEF domain containing G3* / Pleckstrin homology domain-containing family G member 3 *ENSDARG000000966131


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR000719  Protein kinase domain
 IPR001251  CRAL-TRIO lipid binding domain
 IPR001452  SH3 domain
 IPR001849  Pleckstrin homology domain
 IPR002017  Spectrin repeat
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR017441  Protein kinase, ATP binding site
 IPR018159  Spectrin/alpha-actinin
 IPR028570  Triple functional domain protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (q) signalling events
G alpha (12/13) signalling events
DCC mediated attractive signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000011487 gnaq / guanine nucleotide binding protein (G protein), q polypeptide / P50148* / P21279* / G protein subunit alpha q* / guanine nucleotide binding protein, alpha q polypeptide*  / reaction / complex
 ENSDARG00000008107 src / Q1JPZ3 / v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyr...  / complex / reaction
 ENSDARG00000022531 ntn1b / netrin 1b / NTN1* / O09118* / O95631* / netrin 1*  / reaction / complex
 ENSDARG00000105112 ntn1a / netrin 1a / NTN1* / O09118* / O95631* / netrin 1*  / complex / reaction
 ENSDARG00000011370 fyna / Q6EWH2 / FYN proto-oncogene, Src family tyrosine kinase a / FYN* / P06241* / P39688* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSDARG00000075369 nck1b / NCK adaptor protein 1b / NCK1* / P16333* / Q99M51* / NCK adaptor protein 1* / Cytoplasmic protein NCK1 *  / complex / reaction
 ENSDARG00000044573 cdc42 / cell division cycle 42 / P60766* / P60953* / Cell division control *  / complex / reaction
 ENSDARG00000025319 fynb / F1RDG9 / FYN proto-oncogene, Src family tyrosine kinase b / FYN* / P39688* / P06241* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSDARG00000025013 gna14a / guanine nucleotide binding protein (G protein), alpha 14a / GNA14* / P30677* / O95837* / G protein subunit alpha 14* / guanine nucleotide binding protein, alpha 14*  / reaction / complex
 ENSDARG00000016364 gna15.1 / guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 1 / GNA15* / P30679* / P30678* / G protein subunit alpha 15* / guanine nucleotide binding pro...  / complex / reaction






 

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