ENSDARG00000011370


Danio rerio

Features
Gene ID: ENSDARG00000011370
  
Biological name :fyna
  
Synonyms : fyna / FYN proto-oncogene, Src family tyrosine kinase a / Q6EWH2
  
Possible biological names infered from orthology : FYN / FYN proto-oncogene, Src family tyrosine kinase / P06241 / P39688 / Tyrosine-protein kinase Fyn
  
Species: Danio rerio
  
Chr. number: 17
Strand: -1
Band:
Gene start: 15502964
Gene end: 15528597
  
Corresponding Affymetrix probe sets: Dr.15661.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000123888
NCBI entrez gene - 373872     See in Manteia.
RefSeq - NM_001328163
RefSeq Peptide - NP_001315092
swissprot - Q6EWH2
ZFIN ID - ZDB-GENE-030903-5
Ensembl - ENSDARG00000011370
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FYNENSGALG00000015022Gallus gallus
 FYNENSG00000010810Homo sapiens
 FynENSMUSG00000019843Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
fynb / F1RDG9 / FYN proto-oncogene, Src family tyrosine kinase b / FYN* / P39688* / P06241* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*ENSDARG0000002531992
yrk / Yes-related kinaseENSDARG0000000437878
yes1 / clul1 / A1A5H8 / clusterin-like 1 (retinal) / P07947* / Q04736* / YES proto-oncogene 1, Src family tyrosine kinase*ENSDARG0000000594174
src / Q1JPZ3 / v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyr...ENSDARG0000000810769
hck / HCK proto-oncogene, Src family tyrosine kinase / P08103* / P08631* / Tyrosine-protein kinase HCK *ENSDARG0000005864755
lyn / LYN proto-oncogene, Src family tyrosine kinase / P07948* / P25911*ENSDARG0000006791653
blk / BLK proto-oncogene, Src family tyrosine kinase / P16277* / P51451* / Tyrosine-protein kinase Blk *ENSDARG0000000778352
lck / LCK proto-oncogene, Src family tyrosine kinase / P06239* / P06240* / Proto-onco tyrosine-protein kinase LCK *ENSDARG0000010252551
frk / fyn-related Src family tyrosine kinase / P42685* / Q922K9* / Mus musculus fyn-related kinase (Frk), transcript variant 3, mRNA.*ENSDARG0000002780748
ptk6b / PTK6 protein tyrosine kinase 6b / PTK6* / Q64434* / Q13882* / protein tyrosine kinase 6* / PTK6 protein tyrosine kinase 6*ENSDARG0000005995636
ptk6a / PTK6 protein tyrosine kinase 6a / PTK6* / Q64434* / Q13882* / protein tyrosine kinase 6* / PTK6 protein tyrosine kinase 6*ENSDARG0000001794736
SRMS / zgc:194282 / Q9H3Y6* / src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites*ENSDARG0000007778335


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001452  SH3 domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001702 gastrulation with mouth forming second IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007417 central nervous system development IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0034334 adherens junction maintenance IGI
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0042110 T cell activation IBA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0042552 myelination IMP
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0045859 regulation of protein kinase activity IGI
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0050852 T cell receptor signaling pathway IBA
 biological_processGO:0051480 regulation of cytosolic calcium ion concentration IMP
 biological_processGO:0060027 convergent extension involved in gastrulation IGI
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IEA
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
Signaling by ERBB2
Signaling by SCF-KIT
Cell surface interactions at the vascular wall
FCGR activation
DAP12 signaling
Nephrin family interactions
NCAM signaling for neurite out-growth
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
Ephrin signaling
EPH-ephrin mediated repulsion of cells
Sema3A PAK dependent Axon repulsion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
CRMPs in Sema3A signaling
DCC mediated attractive signaling
VEGFA-VEGFR2 Pathway
CD209 (DC-SIGN) signaling
RAF/MAP kinase cascade
Platelet Adhesion to exposed collagen
Reelin signalling pathway
Regulation of signaling by CBL


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000008186 syk / spleen tyrosine kinase / P43405* / P48025* / spleen associated tyrosine kinase*  / reaction / complex
 ENSDARG00000007723 efnb1 / ephrin-B1 / P52795* / P98172*  / complex / reaction
 ENSDARG00000017803 gsk3b / glycogen synthase kinase 3 beta / P49841* / Q9WV60*  / reaction
 ENSDARG00000001769 ptpra / protein tyrosine phosphatase, receptor type, A / P18052* / P18433*  / complex
 ENSDARG00000073848 arhgef7b / Rho guanine nucleotide exchange factor (GEF) 7b / Q14155* / ARHGEF7* / Rho guanine nucleotide exchange factor 7*  / complex / reaction
 ENSDARG00000021539 ephb2b / eph receptor B2b / EPHB2* / P29323* / P54763* / EPH receptor B2* / Ephrin type-B receptor 2 *  / complex / reaction
 ENSDARG00000020164 efnb2a / O73874 / ephrin-B2a / EFNB2* / P52799* / P52800* / ephrin B2*  / complex / reaction
 ENSDARG00000002587 dpysl3 / Q52PJ5 / dihydropyrimidinase-like 3 / Q14195*  / reaction / complex
 ENSDARG00000042277 efnb3b / ephrin-B3b / EFNB3* / Q15768* / ephrin B3*  / complex / reaction
 ENSDARG00000019426 trioa / trio Rho guanine nucleotide exchange factor a / TRIO* / Q0KL02* / O75962* / Triple functional domain protein * / trio Rho guanine nucleotide exchange factor*  / complex / reaction
 ENSDARG00000039489 git1 / G protein-coupled receptor kinase interacting ArfGAP 1 / Q68FF6* / Q9Y2X7* / GIT ArfGAP 1* / ARF GTPase-activating protein GIT1 *  / complex / reaction
 ENSDARG00000043361 nck2b / NCK adaptor protein 2b / NCK2* / O43639* / O55033* / NCK adaptor protein 2* / Cytoplasmic protein NCK2 *  / complex / reaction
 ENSDARG00000038524 pik3r1 / phosphoinositide-3-kinase, regulatory subunit 1 (alpha) / P26450* / P27986* / phosphoinositide-3-kinase regulatory subunit 1*  / complex / reaction
 ENSDARG00000052468 si:dkeyp-80c12.7 / GSK3B (1 of many) / GSK3B* / P49841* / Q9WV60* / glycogen synthase kinase 3 beta*  / reaction
 ENSDARG00000074050 efnb2b / ephrin-B2b / EFNB2* / P52800* / P52799* / ephrin B2*  / complex / reaction
 ENSDARG00000038059 grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000075456 pik3ca / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / complex / reaction
 ENSDARG00000075962 vav3b / vav 3 guanine nucleotide exchange factor b / VAV3* / Q9UKW4* / Q9R0C8* / vav 3 oncogene* / vav guanine nucleotide exchange factor 3*  / complex / reaction
 ENSDARG00000076179 ngef / neuronal guanine nucleotide exchange factor / Q8CHT1* / Q8N5V2* / Ephexin-1 *  / complex
 ENSDARG00000019231 sptan1 / spectrin alpha, non-erythrocytic 1 / SPTA1* / Q13813* / P08032* / P16546* / P02549* / spectrin alpha, erythrocytic 1* / Spectrin alpha chain, erythrocytic 1 * / Spectrin alpha chai...  / complex
 ENSDARG00000018206 nck2a / NCK adaptor protein 2a / NCK2* / O43639* / O55033* / NCK adaptor protein 2* / Cytoplasmic protein NCK2 *  / complex / reaction
 ENSDARG00000075253 pik3cb / phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta / P42338* / Q8BTI9* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform *  / complex / reaction
 ENSDARG00000006299 arhgef7a / Rho guanine nucleotide exchange factor (GEF) 7a / Q14155* / Q9ES28* / ARHGEF7* / Rho guanine nucleotide exchange factor 7*  / reaction / complex
 ENSDARG00000076757 ephb1 / EPH receptor B1 / P54762* / Q8CBF3* / Ephrin type-B receptor 1 *  / complex / reaction
 ENSDARG00000112993 efnb3a / ephrin-B3a / EFNB3* / Q15768* / O35393* / ephrin B3*  / complex / reaction
 ENSDARG00000094894 tyrobp / TYRO protein tyrosine kinase binding protein / O43914* / O54885*  / complex
 ENSDARG00000030376 grin2bb / glutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate b / GRIN2B* / Q13224* / glutamate receptor, ionotropic, NMDA2B (epsilon 2)* / glutamate ionotropic recept...  / complex
 ENSDARG00000044718 vav2 / vav 2 guanine nucleotide exchange factor / Q60992* / P52735* / vav 2 oncogene* / vav guanine nucleotide exchange factor 2*  / reaction / complex
 ENSDARG00000044573 cdc42 / cell division cycle 42 / P60766* / P60953* / Cell division control *  / complex / reaction
 ENSDARG00000056683 cdk5 / cyclin-dependent kinase 5 / P49615* / Q00535* / Cyclin-dependent-like kinase 5 *  / complex
 ENSDARG00000060758 nphs1 / nephrosis 1, congenital, Finnish type (nephrin) / O60500* / Q9QZS7* / Nephrin * / NPHS1, nephrin*  / complex / reaction
 ENSDARG00000045087 cdk5r1b / cyclin-dependent kinase 5, regulatory subunit 1b (p35) / Q15078* / P61809* / CDK5R1* / cyclin dependent kinase 5 regulatory subunit 1* / Cyclin-dependent kinase 5 activator 1 Cycl...  / complex
 ENSDARG00000056998 kirrel1b / kirre like nephrin family adhesion molecule 1b / Q96J84* / Kirrel* / Q80W68* / KIRREL1* / Kin of IRRE-like protein 1 * / kirre like nephrin family adhesion molecule 1*  / reaction / complex
 ENSDARG00000059897 ntrk2a / neurotrophic tyrosine kinase, receptor, type 2a / NTRK2* / Q16620* / P15209* / BDNF/NT-3 growth factors receptor * / neurotrophic receptor tyrosine kinase 2*  / complex
 ENSDARG00000037373 ephb2a / eph receptor B2a / EPHB2* / P29323* / P54763* / EPH receptor B2* / Ephrin type-B receptor 2 *  / complex / reaction
 ENSDARG00000006257 vldlr / very low density lipoprotein receptor / P98155* / P98156*  / reaction
 ENSDARG00000102153 nrp1a / neuropilin 1a / NRP1* / O14786* / P97333* / neuropilin 1*  / complex
 ENSDARG00000103542 O73682 / vegfaa / vascular endothelial growth factor Aa / VEGFA* / Q00731* / P15692* / vascular endothelial growth factor A*  / reaction / complex
 ENSDARG00000017321 kdr / Q5GIT4 / kinase insert domain receptor (a type III receptor tyrosine kinase) / P35968* / kinase insert domain receptor*  / reaction / complex
 ENSDARG00000075853 sh3kbp1 / SH3-domain kinase binding protein 1 / Q8R550* / Q96B97* / SH3 domain containing kinase binding protein 1*  / reaction
 ENSDARG00000075369 nck1b / NCK adaptor protein 1b / NCK1* / P16333* / Q99M51* / NCK adaptor protein 1* / Cytoplasmic protein NCK1 *  / reaction / complex
 ENSDARG00000007172 plxna3 / plexin A3 / P51805* / P70208*  / complex
 ENSDARG00000019328 plxna4 / plexin A4 / Q80UG2* / Q9HCM2*  / complex
 ENSDARG00000042850 nphs2 / nephrosis 2, idiopathic, steroid-resistant (podocin) / Q9NP85* / Q91X05* / Podocin * / NPHS2, podocin*  / complex / reaction
 ENSDARG00000022531 ntn1b / netrin 1b / NTN1* / O09118* / O95631* / netrin 1*  / reaction / complex
 ENSDARG00000037916 cdk5r1a / cyclin-dependent kinase 5, regulatory subunit 1a (p35) / Q15078* / P61809* / CDK5R1* / cyclin dependent kinase 5 regulatory subunit 1* / Cyclin-dependent kinase 5 activator 1 Cycl...  / complex
 ENSDARG00000001634 kirrel1a / kirre like nephrin family adhesion molecule 1a / Q96J84* / Kirrel* / Q80W68* / KIRREL1* / Kin of IRRE-like protein 1 * / kirre like nephrin family adhesion molecule 1*  / reaction / complex
 ENSDARG00000018060 pik3r2 / phosphoinositide-3-kinase, regulatory subunit 2 (beta) / O00459* / O08908* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2* / Phosphatidylinositol 3-kinase regulator...  / complex / reaction
 ENSDARG00000018817 bdnf / brain-derived neurotrophic factor / P21237* / P23560*  / complex
 ENSDARG00000025326 myl12.2 / myosin, light chain 12, genome duplicate 2 / Q3THE2* / MYL12A* / MYL12B* / O14950* / P19105* / myosin light chain 12A* / myosin light chain 12B* / Myosin regulatory light chain 12B *  / reaction
 ENSDARG00000105276 grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / complex / reaction
 ENSDARG00000105112 ntn1a / netrin 1a / NTN1* / O09118* / O95631* / netrin 1*  / reaction / complex
 ENSDARG00000103276 fcer1g / Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide / P20491* / P30273* / Fc fragment of IgE receptor Ig* / High affinity immunoglobulin epsilon receptor subunit gamma *  / complex
 ENSDARG00000016429 farp2 / FERM, RhoGEF and pleckstrin domain protein 2 / O94887* / Q91VS8* / FERM, ARH/RhoGEF and pleckstrin domain protein 2* / FERM, ARHGEF and pleckstrin domain-containing protein 2 *  / complex
 ENSDARG00000067916 lyn / LYN proto-oncogene, Src family tyrosine kinase / P07948* / P25911*  / complex
 ENSDARG00000098511 ntrk2b / neurotrophic tyrosine kinase, receptor, type 2b / NTRK2* / Q16620* / P15209* / BDNF/NT-3 growth factors receptor * / neurotrophic receptor tyrosine kinase 2*  / complex
 ENSDARG00000103490 dpysl4 / dihydropyrimidinase-like 4 / O14531*  / reaction / complex
 ENSDARG00000011449 fes / FES proto-oncogene, tyrosine kinase / P07332* / P16879* / Tyrosine-protein kinase Fes/Fps *  / complex






 

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