ENSDARG00000001769


Danio rerio

Features
Gene ID: ENSDARG00000001769
  
Biological name :ptpra
  
Synonyms : protein tyrosine phosphatase, receptor type, A / ptpra
  
Possible biological names infered from orthology : P18052 / P18433
  
Species: Danio rerio
  
Chr. number: 21
Strand: 1
Band:
Gene start: 15756549
Gene end: 15816317
  
Corresponding Affymetrix probe sets: Dr.8174.1.S1_at (Zebrafish Array)   NM_131888_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000092731
Ensembl peptide - ENSDARP00000003403
NCBI entrez gene - 140818     See in Manteia.
RefSeq - NM_131888
RefSeq Peptide - NP_571963
swissprot - F1QE38
swissprot - F1QAX7
ZFIN ID - ZDB-GENE-020107-1
Ensembl - ENSDARG00000001769
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PTPRAENSGALG00000015995Gallus gallus
 PTPRAENSG00000132670Homo sapiens
 PtpraENSMUSG00000027303Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ptprea / protein tyrosine phosphatase, receptor type, E, a / PTPRE* / P49446* / P23469* / protein tyrosine phosphatase, receptor type E* / Receptor-type tyrosine-protein phosphatase epsilon *ENSDARG0000001589153
ptpreb / protein tyrosine phosphatase, receptor type, E, b / PTPRE* / P49446* / P23469* / protein tyrosine phosphatase, receptor type E* / Receptor-type tyrosine-protein phosphatase epsilon *ENSDARG0000002115152
ptprfa / protein tyrosine phosphatase, receptor type, f, a / PTPRF* / A2A8L5* / P10586* / protein tyrosine phosphatase, receptor type F* / Receptor-type tyrosine-protein phosphatase F *ENSDARG0000010347939
ptprfb / A4IFW2 / protein tyrosine phosphatase, receptor type, f, b / PTPRF* / P10586* / A2A8L5* / Receptor-type tyrosine-protein phosphatase F * / protein tyrosine phosphatase, receptor type F*ENSDARG0000000575439
ptprsa / protein tyrosine phosphatase, receptor type, s, a / PTPRS* / B0V2N1* / Q13332* / Receptor-type tyrosine-protein phosphatase S * / protein tyrosine phosphatase, receptor type S*ENSDARG0000005973839
ptprsa / protein tyrosine phosphatase, receptor type, s, a / PTPRS* / Q13332* / protein tyrosine phosphatase, receptor type S*ENSDARG0000011094035
ptprc / protein tyrosine phosphatase, receptor type, CENSDARG0000007143729
ptprk / protein tyrosine phosphatase, receptor type, K / P35822* / Q15262*ENSDARG0000006341629
ptprt / protein tyrosine phosphatase, receptor type, t / O14522* / Q99M80* / Receptor-type tyrosine-protein phosphatase T *ENSDARG0000007478128
ptprz1a / protein tyrosine phosphatase, receptor-type, Z polypeptide 1a / B9EKR1* / P23471* / PTPRZ1* / protein tyrosine phosphatase, receptor type Z1* / protein tyrosine phosphatase, recep...ENSDARG0000005181427
ptprub / protein tyrosine phosphatase, receptor type, U, b / PTPRU* / B1AUH1* / Q92729* / protein tyrosine phosphatase, receptor type U*ENSDARG0000010108127
ptprt / protein tyrosine phosphatase, receptor type, t / O14522*ENSDARG0000009757227
ptprga / protein tyrosine phosphatase, receptor type, g a / PTPRG* / P23470* / protein tyrosine phosphatase, receptor type G*ENSDARG0000004500627
ca16b / carbonic anhydrase XVI b / PTPRG* / P23470* / protein tyrosine phosphatase, receptor type G* / receptor-type tyrosine-protein phosphatase gamma isoform 2 *ENSDARG0000006012327
ptprz1b / protein tyrosine phosphatase, receptor-type, Z polypeptide 1b / B9EKR1* / P23471* / PTPRZ1* / protein tyrosine phosphatase, receptor type Z1* / protein tyrosine phosphatase, recep...ENSDARG0000002087126
ptprua / protein tyrosine phosphatase, receptor type, U, a / PTPRU* / B1AUH1* / Q92729* / protein tyrosine phosphatase, receptor type U*ENSDARG0000009263826
CABZ01084131.1 / PTPRM* / P28827* / protein tyrosine phosphatase, receptor type M*ENSDARG0000011476212
si:ch1073-391i24.1 / PTPRM* / P28827* / P28828* / protein tyrosine phosphatase, receptor type M*ENSDARG0000008917212


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR016336  Receptor tyrosine-protein phosphatase, alpha/epsilon-type
 IPR027262  Receptor tyrosine-protein phosphatase alpha
 IPR029021  Protein-tyrosine phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0045859 regulation of protein kinase activity IDA
 biological_processGO:0060027 convergent extension involved in gastrulation IMP
 biological_processGO:0060041 retina development in camera-type eye IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA


Pathways (from Reactome)
Pathway description
NCAM signaling for neurite out-growth
RAF/MAP kinase cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000046 retinal neural layer retinal neural layer hypoplastic , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000084 yolk yolk edematous , abnormal
Show

 ZFA:0000106 extension extension decreased length , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0000152 retina retina cell decreased amount , abnormal
retina disorganized , abnormal
Show

 ZFA:0000435 cranial nerve II cranial nerve II defasciculated , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased length , abnormal
whole organism dead , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000019231 sptan1 / spectrin alpha, non-erythrocytic 1 / SPTA1* / Q13813* / P08032* / P16546* / P02549* / spectrin alpha, erythrocytic 1* / Spectrin alpha chain, erythrocytic 1 * / Spectrin alpha chai...  / complex
 ENSDARG00000038059 grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / reaction / complex
 ENSDARG00000025319 fynb / F1RDG9 / FYN proto-oncogene, Src family tyrosine kinase b / FYN* / P39688* / P06241* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex
 ENSDARG00000105276 grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / reaction / complex
 ENSDARG00000011370 fyna / Q6EWH2 / FYN proto-oncogene, Src family tyrosine kinase a / FYN* / P06241* / P39688* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr