ENSG00000132670


Homo sapiens

Features
Gene ID: ENSG00000132670
  
Biological name :PTPRA
  
Synonyms : P18433 / protein tyrosine phosphatase, receptor type A / PTPRA
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: 1
Band: p13
Gene start: 2864184
Gene end: 3039076
  
Corresponding Affymetrix probe sets: 213795_s_at (Human Genome U133 Plus 2.0 Array)   213799_s_at (Human Genome U133 Plus 2.0 Array)   239419_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000414089
Ensembl peptide - ENSP00000390775
Ensembl peptide - ENSP00000394132
Ensembl peptide - ENSP00000216877
Ensembl peptide - ENSP00000314568
Ensembl peptide - ENSP00000348468
Ensembl peptide - ENSP00000369756
Ensembl peptide - ENSP00000382787
NCBI entrez gene - 5786     See in Manteia.
OMIM - 176884
RefSeq - NM_002836
RefSeq - NM_080840
RefSeq - NM_080841
RefSeq Peptide - NP_002827
RefSeq Peptide - NP_543030
RefSeq Peptide - NP_543031
swissprot - P18433
swissprot - Q5JWG0
swissprot - Q5JWG2
swissprot - Q5JWG3
Ensembl - ENSG00000132670
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptpraENSDARG00000001769Danio rerio
 PTPRAENSGALG00000015995Gallus gallus
 PtpraENSMUSG00000027303Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PTPRE / P23469 / protein tyrosine phosphatase, receptor type EENSG0000013233458
PTPRF / P10586 / protein tyrosine phosphatase, receptor type FENSG0000014294944
PTPRS / Q13332 / protein tyrosine phosphatase, receptor type SENSG0000010542644
PTPRD / P23468 / protein tyrosine phosphatase, receptor type DENSG0000015370743
PTPRC / protein tyrosine phosphatase, receptor type CENSG0000008123735
PTPRT / O14522 / protein tyrosine phosphatase, receptor type TENSG0000019609032
PTPRK / Q15262 / protein tyrosine phosphatase, receptor type KENSG0000015289432
PTPRM / P28827 / protein tyrosine phosphatase, receptor type MENSG0000017348232
P23471 / PTPRZ1 / protein tyrosine phosphatase, receptor type Z1ENSG0000010627830
PTPRG / P23470 / protein tyrosine phosphatase, receptor type GENSG0000014472429
PTPRU / Q92729 / protein tyrosine phosphatase, receptor type UENSG0000006065629


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR016336  Receptor tyrosine-protein phosphatase, alpha/epsilon-type
 IPR027262  Receptor tyrosine-protein phosphatase alpha
 IPR029021  Protein-tyrosine phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0007411 axon guidance TAS
 biological_processGO:0008286 insulin receptor signaling pathway IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043235 receptor complex IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity TAS
 molecular_functionGO:0005001 transmembrane receptor protein tyrosine phosphatase activity TAS
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
NCAM signaling for neurite out-growth
RAF/MAP kinase cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000169398 PTK2 / Q05397 / protein tyrosine kinase 2  / reaction / complex
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / reaction / complex
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000010810 FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase  / complex / reaction
 ENSG00000149294 NCAM1 / P13591 / neural cell adhesion molecule 1  / reaction / complex
 ENSG00000197694 Q13813 / SPTAN1 / spectrin alpha, non-erythrocytic 1  / complex / reaction
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / reaction
 ENSG00000163554 SPTA1 / P02549 / spectrin alpha, erythrocytic 1  / complex / reaction






 

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