ENSG00000173482


Homo sapiens

Features
Gene ID: ENSG00000173482
  
Biological name :PTPRM
  
Synonyms : P28827 / protein tyrosine phosphatase, receptor type M / PTPRM
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 18
Strand: 1
Band: p11.23
Gene start: 7566782
Gene end: 8406861
  
Corresponding Affymetrix probe sets: 1555578_at (Human Genome U133 Plus 2.0 Array)   1555579_s_at (Human Genome U133 Plus 2.0 Array)   203329_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000463558
Ensembl peptide - ENSP00000463325
Ensembl peptide - ENSP00000464128
Ensembl peptide - ENSP00000331418
Ensembl peptide - ENSP00000382927
Ensembl peptide - ENSP00000382933
Ensembl peptide - ENSP00000462176
Ensembl peptide - ENSP00000462809
NCBI entrez gene - 5797     See in Manteia.
OMIM - 176888
RefSeq - XM_017025909
RefSeq - XM_017025900
RefSeq - XM_017025901
RefSeq - XM_017025902
RefSeq - XM_017025903
RefSeq - XM_017025904
RefSeq - XM_017025905
RefSeq - XM_017025906
RefSeq - XM_017025907
RefSeq - XM_017025908
RefSeq - NM_001105244
RefSeq - NM_002845
RefSeq - XM_011525708
RefSeq - XM_011525710
RefSeq - XM_011525712
RefSeq - XM_011525713
RefSeq - XM_011525715
RefSeq - XM_011525716
RefSeq - XM_011525717
RefSeq - XM_011525722
RefSeq - XM_017025894
RefSeq - XM_017025895
RefSeq - XM_017025896
RefSeq - XM_017025897
RefSeq - XM_017025898
RefSeq - XM_017025899
RefSeq Peptide - NP_002836
RefSeq Peptide - NP_001098714
swissprot - J3QLI4
swissprot - J3QRB4
swissprot - Q49AC9
swissprot - E7EPS8
swissprot - J3KRV2
swissprot - P28827
swissprot - J3KT55
Ensembl - ENSG00000173482
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01084131.1ENSDARG00000114762Danio rerio
 si:ch1073-391i24.1ENSDARG00000089172Danio rerio
 PTPRMENSGALG00000031284Gallus gallus
 PtprmENSMUSG00000033278Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PTPRT / O14522 / protein tyrosine phosphatase, receptor type TENSG0000019609065
PTPRK / Q15262 / protein tyrosine phosphatase, receptor type KENSG0000015289461
PTPRU / Q92729 / protein tyrosine phosphatase, receptor type UENSG0000006065652
PTPRD / P23468 / protein tyrosine phosphatase, receptor type DENSG0000015370728
PTPRS / Q13332 / protein tyrosine phosphatase, receptor type SENSG0000010542628
PTPRF / P10586 / protein tyrosine phosphatase, receptor type FENSG0000014294928
P23471 / PTPRZ1 / protein tyrosine phosphatase, receptor type Z1ENSG0000010627822
PTPRC / protein tyrosine phosphatase, receptor type CENSG0000008123719
PTPRG / P23470 / protein tyrosine phosphatase, receptor type GENSG0000014472419
PTPRA / P18433 / protein tyrosine phosphatase, receptor type AENSG0000013267018
PTPRE / P23469 / protein tyrosine phosphatase, receptor type EENSG0000013233417


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR000998  MAM domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR003599  Immunoglobulin subtype
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR013151  Immunoglobulin
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR021157  Cytochrome c1, transmembrane anchor, C-terminal
 IPR029021  Protein-tyrosine phosphatase-like
 IPR036116  Fibronectin type III superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001937 negative regulation of endothelial cell proliferation IMP
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IDA
 biological_processGO:0007165 signal transduction IDA
 biological_processGO:0010596 negative regulation of endothelial cell migration IMP
 biological_processGO:0010842 retina layer formation IMP
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0016525 negative regulation of angiogenesis IMP
 biological_processGO:0031175 neuron projection development IMP
 biological_processGO:0031290 retinal ganglion cell axon guidance IDA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0042493 response to drug IDA
 biological_processGO:0097755 positive regulation of blood vessel diameter IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane NAS
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0005913 cell-cell adherens junction IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030027 lamellipodium IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0005001 transmembrane receptor protein tyrosine phosphatase activity IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0045296 cadherin binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr