ENSG00000060656


Homo sapiens

Features
Gene ID: ENSG00000060656
  
Biological name :PTPRU
  
Synonyms : protein tyrosine phosphatase, receptor type U / PTPRU / Q92729
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p35.3
Gene start: 29236516
Gene end: 29326813
  
Corresponding Affymetrix probe sets: 211320_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000334941
Ensembl peptide - ENSP00000362884
Ensembl peptide - ENSP00000392332
Ensembl peptide - ENSP00000432906
NCBI entrez gene - 10076     See in Manteia.
OMIM - 602454
RefSeq - XM_016999995
RefSeq - NM_001195001
RefSeq - NM_005704
RefSeq - NM_133177
RefSeq - NM_133178
RefSeq - XM_006710269
RefSeq - XM_016999992
RefSeq - XM_016999993
RefSeq - XM_016999994
RefSeq Peptide - NP_001181930
RefSeq Peptide - NP_005695
RefSeq Peptide - NP_573438
RefSeq Peptide - NP_573439
swissprot - Q92729
Ensembl - ENSG00000060656
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptpruaENSDARG00000092638Danio rerio
 ptprubENSDARG00000101081Danio rerio
 PTPRUENSGALG00000031440Gallus gallus
 PtpruENSMUSG00000028909Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PTPRK / Q15262 / protein tyrosine phosphatase, receptor type KENSG0000015289459
PTPRM / P28827 / protein tyrosine phosphatase, receptor type MENSG0000017348253
PTPRT / O14522 / protein tyrosine phosphatase, receptor type TENSG0000019609051
PTPRD / P23468 / protein tyrosine phosphatase, receptor type DENSG0000015370727
PTPRF / P10586 / protein tyrosine phosphatase, receptor type FENSG0000014294926
PTPRS / Q13332 / protein tyrosine phosphatase, receptor type SENSG0000010542626
P23471 / PTPRZ1 / protein tyrosine phosphatase, receptor type Z1ENSG0000010627820
PTPRC / protein tyrosine phosphatase, receptor type CENSG0000008123719
PTPRG / P23470 / protein tyrosine phosphatase, receptor type GENSG0000014472418
PTPRA / P18433 / protein tyrosine phosphatase, receptor type AENSG0000013267016
PTPRE / P23469 / protein tyrosine phosphatase, receptor type EENSG0000013233415


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR000998  MAM domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR003961  Fibronectin type III
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR029021  Protein-tyrosine phosphatase-like
 IPR036116  Fibronectin type III superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IDA
 biological_processGO:0007155 cell adhesion NAS
 biological_processGO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway NAS
 biological_processGO:0008285 negative regulation of cell proliferation IDA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030336 negative regulation of cell migration IDA
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0034109 homotypic cell-cell adhesion IEA
 biological_processGO:0034394 protein localization to cell surface IDA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0060070 canonical Wnt signaling pathway IDA
 biological_processGO:0098609 cell-cell adhesion IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane NAS
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IMP
 molecular_functionGO:0005001 transmembrane receptor protein tyrosine phosphatase activity NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
Signaling by SCF-KIT


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000157404 KIT / P10721 / KIT proto-oncogene receptor tyrosine kinase  / reaction / complex






 

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