ENSG00000105426


Homo sapiens

Features
Gene ID: ENSG00000105426
  
Biological name :PTPRS
  
Synonyms : protein tyrosine phosphatase, receptor type S / PTPRS / Q13332
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: p13.3
Gene start: 5158495
Gene end: 5340803
  
Corresponding Affymetrix probe sets: 1555666_at (Human Genome U133 Plus 2.0 Array)   210823_s_at (Human Genome U133 Plus 2.0 Array)   226571_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000468455
Ensembl peptide - ENSP00000467537
Ensembl peptide - ENSP00000468803
Ensembl peptide - ENSP00000262963
Ensembl peptide - ENSP00000327313
Ensembl peptide - ENSP00000465185
Ensembl peptide - ENSP00000465443
Ensembl peptide - ENSP00000467398
NCBI entrez gene - 5802     See in Manteia.
OMIM - 601576
RefSeq - XM_017027076
RefSeq - XM_017027066
RefSeq - XM_017027067
RefSeq - XM_017027068
RefSeq - XM_017027069
RefSeq - XM_017027070
RefSeq - XM_017027071
RefSeq - XM_017027072
RefSeq - XM_017027073
RefSeq - XM_017027074
RefSeq - XM_017027075
RefSeq - NM_002850
RefSeq - NM_130853
RefSeq - NM_130854
RefSeq - NM_130855
RefSeq - XM_005259600
RefSeq - XM_005259606
RefSeq - XM_005259607
RefSeq - XM_005259609
RefSeq - XM_005259610
RefSeq - XM_011528157
RefSeq - XM_011528158
RefSeq - XM_017027065
RefSeq Peptide - NP_570925
RefSeq Peptide - NP_002841
RefSeq Peptide - NP_570923
RefSeq Peptide - NP_570924
swissprot - G8JL96
swissprot - A0A0A0MR60
swissprot - Q8NHS7
swissprot - K7ERX4
swissprot - K7ESP0
swissprot - Q13332
Ensembl - ENSG00000105426
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptprsaENSDARG00000059738Danio rerio
 ptprsaENSDARG00000110940Danio rerio
 PTPRSENSGALG00000004048Gallus gallus
 PtprsENSMUSG00000013236Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PTPRD / P23468 / protein tyrosine phosphatase, receptor type DENSG0000015370771
PTPRF / P10586 / protein tyrosine phosphatase, receptor type FENSG0000014294966
P23471 / PTPRZ1 / protein tyrosine phosphatase, receptor type Z1ENSG0000010627822
PTPRM / P28827 / protein tyrosine phosphatase, receptor type MENSG0000017348221
PTPRK / Q15262 / protein tyrosine phosphatase, receptor type KENSG0000015289420
PTPRT / O14522 / protein tyrosine phosphatase, receptor type TENSG0000019609020
PTPRU / Q92729 / protein tyrosine phosphatase, receptor type UENSG0000006065619
PTPRG / P23470 / protein tyrosine phosphatase, receptor type GENSG0000014472418
PTPRC / protein tyrosine phosphatase, receptor type CENSG0000008123718
PTPRA / P18433 / protein tyrosine phosphatase, receptor type AENSG0000013267018
PTPRE / P23469 / protein tyrosine phosphatase, receptor type EENSG0000013233416


Protein motifs (from Interpro)
Interpro ID Name
 IPR000242  PTP type protein phosphatase
 IPR000387  Tyrosine specific protein phosphatases domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR029021  Protein-tyrosine phosphatase-like
 IPR036116  Fibronectin type III superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0010977 negative regulation of neuron projection development ISS
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0021510 spinal cord development IEA
 biological_processGO:0021549 cerebellum development IEA
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0021987 cerebral cortex development IEA
 biological_processGO:0022038 corpus callosum development IEA
 biological_processGO:0030517 negative regulation of axon extension ISS
 biological_processGO:0032687 negative regulation of interferon-alpha production IMP
 biological_processGO:0032688 negative regulation of interferon-beta production IMP
 biological_processGO:0034164 negative regulation of toll-like receptor 9 signaling pathway IMP
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0048671 negative regulation of collateral sprouting ISS
 biological_processGO:0048681 negative regulation of axon regeneration ISS
 biological_processGO:0061000 negative regulation of dendritic spine development ISS
 biological_processGO:0090557 establishment of endothelial intestinal barrier IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030285 integral component of synaptic vesicle membrane ISS
 cellular_componentGO:0030424 axon ISS
 cellular_componentGO:0030672 synaptic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0099061 integral component of postsynaptic density membrane ISS
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008201 heparin binding ISS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0035374 chondroitin sulfate binding ISS
 molecular_functionGO:0043395 heparan sulfate proteoglycan binding ISS


Pathways (from Reactome)
Pathway description
ECM proteoglycans
Receptor-type tyrosine-protein phosphatases
Synaptic adhesion-like molecules
Signaling by NTRK3 (TRKC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000110841 Q86W92 / PPFIBP1 / PPFIA binding protein 1  / reaction / complex
 ENSG00000131626 PPFIA1 / Q13136 / PTPRF interacting protein alpha 1  / complex / reaction
 ENSG00000188157 AGRN / agrin / O00468  / complex / reaction
 ENSG00000131409 LRRC4B / Q9NT99 / leucine rich repeat containing 4B  / complex / reaction
 ENSG00000140538 NTRK3 / Q16288 / neurotrophic receptor tyrosine kinase 3  / complex / reaction
 ENSG00000166387 Q8ND30 / PPFIBP2 / PPFIA binding protein 2  / complex / reaction
 ENSG00000143847 O75335 / PPFIA4 / PTPRF interacting protein alpha 4  / complex / reaction
 ENSG00000173621 LRFN4 / Q6PJG9 / leucine rich repeat and fibronectin type III domain containing 4  / reaction / complex
 ENSG00000177380 O75145 / PPFIA3 / PTPRF interacting protein alpha 3  / complex / reaction
 ENSG00000139220 O75334 / PPFIA2 / PTPRF interacting protein alpha 2  / complex / reaction






 

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