ENSG00000140538


Homo sapiens

Features
Gene ID: ENSG00000140538
  
Biological name :NTRK3
  
Synonyms : neurotrophic receptor tyrosine kinase 3 / NTRK3 / Q16288
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q25.3
Gene start: 87859751
Gene end: 88256768
  
Corresponding Affymetrix probe sets: 1557795_s_at (Human Genome U133 Plus 2.0 Array)   206462_s_at (Human Genome U133 Plus 2.0 Array)   213960_at (Human Genome U133 Plus 2.0 Array)   215025_at (Human Genome U133 Plus 2.0 Array)   215115_x_at (Human Genome U133 Plus 2.0 Array)   215311_at (Human Genome U133 Plus 2.0 Array)   217033_x_at (Human Genome U133 Plus 2.0 Array)   217377_x_at (Human Genome U133 Plus 2.0 Array)   228849_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000473656
Ensembl peptide - ENSP00000473475
Ensembl peptide - ENSP00000480693
Ensembl peptide - ENSP00000486784
Ensembl peptide - ENSP00000485864
Ensembl peptide - ENSP00000318328
Ensembl peptide - ENSP00000347397
Ensembl peptide - ENSP00000350356
Ensembl peptide - ENSP00000354207
Ensembl peptide - ENSP00000377990
Ensembl peptide - ENSP00000437773
Ensembl peptide - ENSP00000444673
Ensembl peptide - ENSP00000453511
Ensembl peptide - ENSP00000453959
Ensembl peptide - ENSP00000473315
NCBI entrez gene - 4916     See in Manteia.
OMIM - 191316
RefSeq - XM_017022254
RefSeq - XM_006720549
RefSeq - XM_006720550
RefSeq - XM_011521637
RefSeq - XM_011521638
RefSeq - XM_017022240
RefSeq - XM_017022241
RefSeq - XM_017022242
RefSeq - XM_017022243
RefSeq - XM_017022244
RefSeq - XM_017022245
RefSeq - XM_017022246
RefSeq - XM_017022247
RefSeq - XM_017022248
RefSeq - XM_017022249
RefSeq - XM_017022250
RefSeq - XM_017022251
RefSeq - XM_017022252
RefSeq - XM_017022253
RefSeq - NM_001007156
RefSeq - NM_001012338
RefSeq - NM_001243101
RefSeq - NM_001320134
RefSeq - NM_001320135
RefSeq - NM_002530
RefSeq - XM_006720543
RefSeq - XM_006720544
RefSeq - XM_006720545
RefSeq - XM_006720548
RefSeq Peptide - NP_001307063
RefSeq Peptide - NP_001307064
RefSeq Peptide - NP_002521
RefSeq Peptide - NP_001007157
RefSeq Peptide - NP_001012338
RefSeq Peptide - NP_001230030
swissprot - X5D7M5
swissprot - X5DNW6
swissprot - A0A087WX31
swissprot - Q16288
swissprot - Q96CY4
swissprot - B7Z7U4
swissprot - R4GMR8
swissprot - A0A0D9SFP6
swissprot - H0YM90
swissprot - R4GN40
swissprot - R4GNH5
swissprot - X5D2R1
Ensembl - ENSG00000140538
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ntrk3aENSDARG00000077228Danio rerio
 ntrk3bENSDARG00000086214Danio rerio
 NTRK3ENSGALG00000040241Gallus gallus
 Ntrk3ENSMUSG00000059146Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NTRK2 / Q16620 / neurotrophic receptor tyrosine kinase 2ENSG0000014805353
NTRK1 / P04629 / neurotrophic receptor tyrosine kinase 1ENSG0000019840048
MUSK / O15146 / muscle associated receptor tyrosine kinaseENSG0000003030427
IGF1R / P08069 / insulin like growth factor 1 receptorENSG0000014044325
INSRR / P14616 / insulin receptor related receptorENSG0000002764424
DDR1 / Q08345 / discoidin domain receptor tyrosine kinase 1ENSG0000020458024
INSR / P06213 / insulin receptorENSG0000017110524
ROS1 / P08922 / ROS proto-oncogene 1, receptor tyrosine kinaseENSG0000004793623
DDR2 / Q16832 / discoidin domain receptor tyrosine kinase 2ENSG0000016273323
ROR2 / Q01974 / receptor tyrosine kinase like orphan receptor 2ENSG0000016907121
ROR1 / Q01973 / receptor tyrosine kinase like orphan receptor 1ENSG0000018548321
ALK / Q9UM73 / ALK receptor tyrosine kinaseENSG0000017109421
PTK7 / Q13308 / protein tyrosine kinase 7 (inactive)ENSG0000011265519
LTK / P29376 / leukocyte receptor tyrosine kinaseENSG0000006252416


Protein motifs (from Interpro)
Interpro ID Name
 IPR000372  Leucine-rich repeat N-terminal domain
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001611  Leucine-rich repeat
 IPR002011  Tyrosine-protein kinase, receptor class II, conserved site
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013098  Immunoglobulin I-set
 IPR013151  Immunoglobulin
 IPR013783  Immunoglobulin-like fold
 IPR017441  Protein kinase, ATP binding site
 IPR020446  Tyrosine-protein kinase, neurotrophic receptor, type 3
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR020777  Tyrosine-protein kinase, neurotrophic receptor
 IPR031635  Tyrosine-protein kinase receptor NTRK, C2-Ig-like domain
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IDA
 biological_processGO:0001764 neuron migration IEA
 biological_processGO:0001933 negative regulation of protein phosphorylation IDA
 biological_processGO:0001934 positive regulation of protein phosphorylation TAS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0019056 modulation by virus of host transcription IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030335 positive regulation of cell migration IDA
 biological_processGO:0032148 activation of protein kinase B activity IDA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IDA
 biological_processGO:0038179 neurotrophin signaling pathway IEA
 biological_processGO:0042490 mechanoreceptor differentiation IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0048013 ephrin receptor signaling pathway IEA
 biological_processGO:0048665 neuron fate specification IEA
 biological_processGO:0048678 response to axon injury IEA
 biological_processGO:0048691 positive regulation of axon extension involved in regeneration IEA
 biological_processGO:0048712 negative regulation of astrocyte differentiation IEA
 biological_processGO:0050927 positive regulation of positive chemotaxis IDA
 biological_processGO:0051412 response to corticosterone IEA
 biological_processGO:0051965 positive regulation of synapse assembly IEA
 biological_processGO:0060548 negative regulation of cell death IEA
 biological_processGO:0070306 lens fiber cell differentiation IEA
 biological_processGO:0071300 cellular response to retinoic acid IEA
 biological_processGO:0090102 cochlea development IEA
 biological_processGO:0090630 activation of GTPase activity IDA
 biological_processGO:2000251 positive regulation of actin cytoskeleton reorganization IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043235 receptor complex IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0002039 p53 binding IPI
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005004 GPI-linked ephrin receptor activity IEA
 molecular_functionGO:0005030 neurotrophin receptor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0043121 neurotrophin binding TAS


Pathways (from Reactome)
Pathway description
Receptor-type tyrosine-protein phosphatases
NTF3 activates NTRK3 signaling
Signaling by NTRK3 (TRKC)
Activated NTRK3 signals through PLCG1
Activated NTRK3 signals through RAS
Activated NTRK3 signals through PI3K
NTRK3 as a dependence receptor


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000121879 P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha  / complex / reaction
 ENSG00000105426 PTPRS / Q13332 / protein tyrosine phosphatase, receptor type S  / complex / reaction
 ENSG00000145675 P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1  / reaction / complex
 ENSG00000124181 PLCG1 / P19174 / phospholipase C gamma 1  / complex / reaction
 ENSG00000140538 NTRK3 / Q16288 / neurotrophic receptor tyrosine kinase 3  / complex / reaction
 ENSG00000188986 NELFB / Q8WX92 / negative elongation factor complex member B  / complex / reaction
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / complex
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / complex
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / reaction / complex
 ENSG00000185652 NTF3 / P20783 / neurotrophin 3  / reaction / complex
 ENSG00000160691 SHC1 / P29353 / SHC adaptor protein 1  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr