ENSG00000185483


Homo sapiens

Features
Gene ID: ENSG00000185483
  
Biological name :ROR1
  
Synonyms : Q01973 / receptor tyrosine kinase like orphan receptor 1 / ROR1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p31.3
Gene start: 63774022
Gene end: 64181498
  
Corresponding Affymetrix probe sets: 205805_s_at (Human Genome U133 Plus 2.0 Array)   211057_at (Human Genome U133 Plus 2.0 Array)   232060_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000441637
Ensembl peptide - ENSP00000360120
Ensembl peptide - ENSP00000360121
NCBI entrez gene - 4919     See in Manteia.
OMIM - 602336
RefSeq - XM_017001377
RefSeq - NM_001083592
RefSeq - NM_005012
RefSeq - XM_011541526
RefSeq - XM_017001376
RefSeq Peptide - NP_001077061
RefSeq Peptide - NP_005003
swissprot - Q01973
swissprot - A0A0A0MTJ5
Ensembl - ENSG00000185483
  
Related genetic diseases (OMIM): 617654 - ?Deafness, autosomal recessive 108, 617654
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ror1ENSDARG00000015176Danio rerio
 ROR1ENSGALG00000011019Gallus gallus
 Ror1ENSMUSG00000035305Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ROR2 / Q01974 / receptor tyrosine kinase like orphan receptor 2ENSG0000016907158
MUSK / O15146 / muscle associated receptor tyrosine kinaseENSG0000003030421
NTRK2 / Q16620 / neurotrophic receptor tyrosine kinase 2ENSG0000014805320
IGF1R / P08069 / insulin like growth factor 1 receptorENSG0000014044320
INSR / P06213 / insulin receptorENSG0000017110520
NTRK1 / P04629 / neurotrophic receptor tyrosine kinase 1ENSG0000019840019
ALK / Q9UM73 / ALK receptor tyrosine kinaseENSG0000017109419
ROS1 / P08922 / ROS proto-oncogene 1, receptor tyrosine kinaseENSG0000004793618
NTRK3 / Q16288 / neurotrophic receptor tyrosine kinase 3ENSG0000014053818
INSRR / P14616 / insulin receptor related receptorENSG0000002764418
DDR2 / Q16832 / discoidin domain receptor tyrosine kinase 2ENSG0000016273316
DDR1 / Q08345 / discoidin domain receptor tyrosine kinase 1ENSG0000020458016
LTK / P29376 / leukocyte receptor tyrosine kinaseENSG0000006252415
PTK7 / Q13308 / protein tyrosine kinase 7 (inactive)ENSG0000011265514


Protein motifs (from Interpro)
Interpro ID Name
 IPR000001  Kringle
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR013806  Kringle-like fold
 IPR016247  Tyrosine-protein kinase, receptor ROR
 IPR018056  Kringle, conserved site
 IPR020067  Frizzled domain
 IPR036179  Immunoglobulin-like domain superfamily
 IPR036790  Frizzled cysteine-rich domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0007605 sensory perception of sound IMP
 biological_processGO:0014002 astrocyte development IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
 biological_processGO:0048839 inner ear development IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IMP
 biological_processGO:0060071 Wnt signaling pathway, planar cell polarity pathway IEA
 cellular_componentGO:0001725 stress fiber IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043235 receptor complex IDA
 cellular_componentGO:0043679 axon terminus IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017147 Wnt-protein binding IPI
 molecular_functionGO:0042813 Wnt-activated receptor activity IMP
 molecular_functionGO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway TAS


Pathways (from Reactome)
Pathway description
WNT5A-dependent internalization of FZD2, FZD5 and ROR2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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