ENSG00000204580


Homo sapiens

Features
Gene ID: ENSG00000204580
  
Biological name :DDR1
  
Synonyms : DDR1 / discoidin domain receptor tyrosine kinase 1 / Q08345
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: p21.33
Gene start: 30876421
Gene end: 30900156
  
Corresponding Affymetrix probe sets: 1007_s_at (Human Genome U133 Plus 2.0 Array)   207169_x_at (Human Genome U133 Plus 2.0 Array)   208779_x_at (Human Genome U133 Plus 2.0 Array)   210749_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000407699
Ensembl peptide - ENSP00000406091
Ensembl peptide - ENSP00000409400
Ensembl peptide - ENSP00000427597
Ensembl peptide - ENSP00000427552
Ensembl peptide - ENSP00000427369
Ensembl peptide - ENSP00000427124
Ensembl peptide - ENSP00000426799
Ensembl peptide - ENSP00000426420
Ensembl peptide - ENSP00000426229
Ensembl peptide - ENSP00000425713
Ensembl peptide - ENSP00000425113
Ensembl peptide - ENSP00000424758
Ensembl peptide - ENSP00000424703
Ensembl peptide - ENSP00000424468
Ensembl peptide - ENSP00000424346
Ensembl peptide - ENSP00000424003
Ensembl peptide - ENSP00000423928
Ensembl peptide - ENSP00000423906
Ensembl peptide - ENSP00000423749
Ensembl peptide - ENSP00000423492
Ensembl peptide - ENSP00000422974
Ensembl peptide - ENSP00000422467
Ensembl peptide - ENSP00000422442
Ensembl peptide - ENSP00000422331
Ensembl peptide - ENSP00000422108
Ensembl peptide - ENSP00000421978
Ensembl peptide - ENSP00000421753
Ensembl peptide - ENSP00000421719
Ensembl peptide - ENSP00000421189
Ensembl peptide - ENSP00000421152
Ensembl peptide - ENSP00000420833
Ensembl peptide - ENSP00000409682
Ensembl peptide - ENSP00000318217
Ensembl peptide - ENSP00000365751
Ensembl peptide - ENSP00000365752
Ensembl peptide - ENSP00000365753
Ensembl peptide - ENSP00000365754
Ensembl peptide - ENSP00000365759
Ensembl peptide - ENSP00000379631
Ensembl peptide - ENSP00000390593
Ensembl peptide - ENSP00000392413
Ensembl peptide - ENSP00000394273
Ensembl peptide - ENSP00000398682
Ensembl peptide - ENSP00000405039
Ensembl peptide - ENSP00000405998
NCBI entrez gene - 780     See in Manteia.
OMIM - 600408
RefSeq - NM_001202523
RefSeq - NM_001202521
RefSeq - NM_001202522
RefSeq - NM_001297652
RefSeq - NM_001297653
RefSeq - NM_001297654
RefSeq - NM_001954
RefSeq - NM_013993
RefSeq - NM_013994
RefSeq - XM_006715185
RefSeq - XM_011514882
RefSeq - XM_011514883
RefSeq - XM_011514884
RefSeq - XM_011514885
RefSeq - XM_011514886
RefSeq - XM_011514887
RefSeq - XM_011514888
RefSeq - XM_017011268
RefSeq - XM_017011269
RefSeq Peptide - NP_001189452
RefSeq Peptide - NP_001284582
RefSeq Peptide - NP_001284583
RefSeq Peptide - NP_001945
RefSeq Peptide - NP_054699
RefSeq Peptide - NP_054700
RefSeq Peptide - NP_001284581
RefSeq Peptide - NP_001189450
RefSeq Peptide - NP_001189451
swissprot - A0A0A0MSX3
swissprot - A0A024RCQ1
swissprot - A0A024RCL1
swissprot - H0Y717
swissprot - H0Y9F4
swissprot - H0YAH6
swissprot - A0A024RCJ0
swissprot - Q08345
swissprot - E7EXB0
swissprot - E7EX99
swissprot - E7EVW6
swissprot - E7EVT1
swissprot - E7EUP7
swissprot - E7EUD5
swissprot - E7ETX3
swissprot - E7ETI3
swissprot - E7ESR9
swissprot - E7ES06
swissprot - E7ERN0
swissprot - E7ERI6
swissprot - E7EQ30
swissprot - E7EQ23
swissprot - E7EPN2
swissprot - E7EPH4
swissprot - E7ENJ2
swissprot - D6RGW5
swissprot - E7EN94
swissprot - D6RBU7
swissprot - D6RB82
swissprot - D6RB35
swissprot - D6RAJ3
swissprot - D6R9C4
swissprot - A2ABM8
swissprot - A2ABL2
swissprot - A2ABL0
Ensembl - ENSG00000204580
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ddr1ENSDARG00000078523Danio rerio
 DDR1ENSGALG00000008616Gallus gallus
 Ddr1ENSMUSG00000003534Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DDR2 / Q16832 / discoidin domain receptor tyrosine kinase 2ENSG0000016273352
NTRK1 / P04629 / neurotrophic receptor tyrosine kinase 1ENSG0000019840022
NTRK3 / Q16288 / neurotrophic receptor tyrosine kinase 3ENSG0000014053822
INSRR / P14616 / insulin receptor related receptorENSG0000002764421
NTRK2 / Q16620 / neurotrophic receptor tyrosine kinase 2ENSG0000014805321
INSR / P06213 / insulin receptorENSG0000017110520
MUSK / O15146 / muscle associated receptor tyrosine kinaseENSG0000003030420
IGF1R / P08069 / insulin like growth factor 1 receptorENSG0000014044319
ROS1 / P08922 / ROS proto-oncogene 1, receptor tyrosine kinaseENSG0000004793619
ALK / Q9UM73 / ALK receptor tyrosine kinaseENSG0000017109418
ROR2 / Q01974 / receptor tyrosine kinase like orphan receptor 2ENSG0000016907116
ROR1 / Q01973 / receptor tyrosine kinase like orphan receptor 1ENSG0000018548316
PTK7 / Q13308 / protein tyrosine kinase 7 (inactive)ENSG0000011265515
LTK / P29376 / leukocyte receptor tyrosine kinaseENSG0000006252414


Protein motifs (from Interpro)
Interpro ID Name
 IPR000421  Coagulation factor 5/8 C-terminal domain
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR002011  Tyrosine-protein kinase, receptor class II, conserved site
 IPR008266  Tyrosine-protein kinase, active site
 IPR008979  Galactose-binding-like domain superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR029553  Epithelial discoidin domain-containing receptor 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth IEA
 biological_processGO:0001952 regulation of cell-matrix adhesion IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007155 cell adhesion TAS
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0007566 embryo implantation IEA
 biological_processGO:0007595 lactation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010715 regulation of extracellular matrix disassembly IMP
 biological_processGO:0014909 smooth muscle cell migration IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030198 extracellular matrix organization TAS
 biological_processGO:0038063 collagen-activated tyrosine kinase receptor signaling pathway IMP
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IDA
 biological_processGO:0043583 ear development IEA
 biological_processGO:0044319 wound healing, spreading of cells IMP
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0060444 branching involved in mammary gland duct morphogenesis IEA
 biological_processGO:0060749 mammary gland alveolus development IEA
 biological_processGO:0061302 smooth muscle cell-matrix adhesion IMP
 biological_processGO:0061564 axon development IEA
 biological_processGO:1990138 neuron projection extension IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space HDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043235 receptor complex IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005518 collagen binding IMP
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0038062 protein tyrosine kinase collagen receptor activity IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Non-integrin membrane-ECM interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000204580 DDR1 / Q08345 / discoidin domain receptor tyrosine kinase 1  / complex






 

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