ENSMUSG00000003534


Mus musculus

Features
Gene ID: ENSMUSG00000003534
  
Biological name :Ddr1
  
Synonyms : Ddr1 / Epithelial discoidin domain-containing receptor 1 / Q03146
  
Possible biological names infered from orthology : discoidin domain receptor tyrosine kinase 1 / Q08345
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: B1
Gene start: 35681567
Gene end: 35704621
  
Corresponding Affymetrix probe sets: 10450579 (MoGene1.0st)   1415797_at (Mouse Genome 430 2.0 Array)   1415798_at (Mouse Genome 430 2.0 Array)   1435820_x_at (Mouse Genome 430 2.0 Array)   1437619_x_at (Mouse Genome 430 2.0 Array)   1438367_x_at (Mouse Genome 430 2.0 Array)   1439382_x_at (Mouse Genome 430 2.0 Array)   1456226_x_at (Mouse Genome 430 2.0 Array)   1459990_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120635
Ensembl peptide - ENSMUSP00000119397
Ensembl peptide - ENSMUSP00000122191
Ensembl peptide - ENSMUSP00000133659
Ensembl peptide - ENSMUSP00000133047
Ensembl peptide - ENSMUSP00000122361
Ensembl peptide - ENSMUSP00000003628
Ensembl peptide - ENSMUSP00000094945
Ensembl peptide - ENSMUSP00000112570
Ensembl peptide - ENSMUSP00000113062
Ensembl peptide - ENSMUSP00000117301
Ensembl peptide - ENSMUSP00000117427
NCBI entrez gene - 12305     See in Manteia.
MGI - MGI:99216
RefSeq - XM_011246259
RefSeq - NM_001198831
RefSeq - NM_001198833
RefSeq - NM_007584
RefSeq - NM_172962
RefSeq - XM_006523533
RefSeq - XM_006523534
RefSeq - XM_006523535
RefSeq - XM_006523536
RefSeq - XM_006523537
RefSeq - XM_006523538
RefSeq Peptide - NP_766550
RefSeq Peptide - NP_001185762
RefSeq Peptide - NP_031610
RefSeq Peptide - NP_001185760
swissprot - F7BZR8
swissprot - G3UXE5
swissprot - B0V2H9
swissprot - Q03146
swissprot - Q544T2
swissprot - B0V2H8
swissprot - E9PW79
swissprot - D6RII6
swissprot - B0V2I0
Ensembl - ENSMUSG00000003534
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ddr1ENSDARG00000078523Danio rerio
 DDR1ENSGALG00000008616Gallus gallus
 DDR1ENSG00000204580Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ddr2 / Q62371 / Discoidin domain-containing receptor 2 / Q16832* / discoidin domain receptor tyrosine kinase 2*ENSMUSG0000002667452
Ntrk1 / Q3UFB7 / High affinity nerve growth factor receptor / P04629* / neurotrophic receptor tyrosine kinase 1*ENSMUSG0000002807222
Ntrk2 / P15209 / BDNF/NT-3 growth factors receptor / Q16620* / neurotrophic receptor tyrosine kinase 2*ENSMUSG0000005525422
Ntrk3 / Q6VNS1 / NT-3 growth factor receptor / Q16288* / neurotrophic receptor tyrosine kinase 3*ENSMUSG0000005914622
Insrr / Q9WTL4 / Insulin receptor-related protein Insulin receptor-related protein alpha chain Insulin receptor-related protein beta chain / P14616* / insulin receptor related receptor*ENSMUSG0000000564021
Insr / P15208 / Insulin receptor Insulin receptor subunit alpha Insulin receptor subunit beta / P06213* / insulin receptor*ENSMUSG0000000553420
Musk / Q61006 / Muscle, skeletal receptor tyrosine-protein kinase / O15146* / muscle associated receptor tyrosine kinase*ENSMUSG0000005728020
Alk / P97793 / ALK tyrosine kinase receptor / Q9UM73* / ALK receptor tyrosine kinase*ENSMUSG0000005547119
Ros1 / Q78DX7 / Proto-onco tyrosine-protein kinase ROS / P08922* / ROS proto-oncogene 1, receptor tyrosine kinase*ENSMUSG0000001989319
Igf1r / insulin like growth factor 1 receptor / P08069*ENSMUSG0000000553319
Ror1 / Q9Z139 / Inactive tyrosine-protein kinase transmembrane receptor ROR1 / Q01973* / receptor tyrosine kinase like orphan receptor 1*ENSMUSG0000003530517
Ror2 / Q9Z138 / receptor tyrosine kinase-like orphan receptor 2 / Q01974*ENSMUSG0000002146416
Ptk7 / Q8BKG3 / Inactive tyrosine-protein kinase 7 / Q13308* / protein tyrosine kinase 7 (inactive)*ENSMUSG0000002397215
Ltk / P08923 / Leukocyte tyrosine kinase receptor / P29376* / leukocyte receptor tyrosine kinase*ENSMUSG0000002729714


Protein motifs (from Interpro)
Interpro ID Name
 IPR000421  Coagulation factor 5/8 C-terminal domain
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR002011  Tyrosine-protein kinase, receptor class II, conserved site
 IPR008266  Tyrosine-protein kinase, active site
 IPR008979  Galactose-binding-like domain superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR029553  Epithelial discoidin domain-containing receptor 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth IMP
 biological_processGO:0001952 regulation of cell-matrix adhesion IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0007566 embryo implantation IMP
 biological_processGO:0007595 lactation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0010715 regulation of extracellular matrix disassembly IMP
 biological_processGO:0014909 smooth muscle cell migration IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0038063 collagen-activated tyrosine kinase receptor signaling pathway IMP
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation ISS
 biological_processGO:0043583 ear development IMP
 biological_processGO:0044319 wound healing, spreading of cells IMP
 biological_processGO:0046777 protein autophosphorylation ISO
 biological_processGO:0060444 branching involved in mammary gland duct morphogenesis IMP
 biological_processGO:0060749 mammary gland alveolus development IMP
 biological_processGO:0061302 smooth muscle cell-matrix adhesion IMP
 biological_processGO:0061564 axon development IMP
 biological_processGO:1990138 neuron projection extension IMP
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043235 receptor complex ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005518 collagen binding IMP
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0038062 protein tyrosine kinase collagen receptor activity ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Non-integrin membrane-ECM interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pde6brd1/Pde6brd1,Tg(OPN1LW-DT)1Mame/?
Genetic Background: involves: C3H/He * C57BL/6 * C57BL/6J

Allelic Composition: Ddr1tm1Wfv/Ddr1tm1Wfv
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000628 abnormal mammary gland development "aberration in the differentiation of the mammary gland during early embryogenesis or during sexual maturity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: GckRgsc702/GckRgsc702
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
Show

Allelic Composition: Gria2tm1Lex/Gria2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Gria2tm1Lex/Gria2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001728 failure of implantation "inability of the blastocyst to attach to the endometrium of the uterus" [J:38772]
Show

Allelic Composition: GckRgsc702/GckRgsc702
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: GckRgsc702/GckRgsc702
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0001882 abnormal lactation "atypical production of milk from the mammary gland" [J:51296]
Show

Allelic Composition: GckRgsc702/GckRgsc702
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0002177 abnormal outer ear morphology "malformation or malfunction of any components of the auricles or external acoustic meatus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: GckRgsc702/GckRgsc702
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: GckRgsc702/GckRgsc702
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Il4tm2Nnt/Il4tm2Nnt
Genetic Background: BALB/c-Il4tm2Nnt

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Ddr1tm1Wfv/Ddr1tm1Wfv,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

 MP:0005338 atherosclerotic lesions "thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ddr1tm1Wfv/Ddr1tm1Wfv,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

 MP:0008060 abnormal podocyte slit diaphragm morphology "any structural anomaly of the thin membrane that covers the podocyte filtration slit which allows small molecules such as water, glucose, and ionic salts to pass through while retaining larger macromolecules in the bloodstream" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il4tm2Nnt/Il4tm2Nnt
Genetic Background: BALB/c-Il4tm2Nnt

 MP:0009503 abnormal mammary gland duct morphology "any structural anomaly of the canals that lead from the lobes of the mammary gland to the tip of the nipple and are responsible for carrying milk toward the nipple in a lactating female" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: GckRgsc702/GckRgsc702
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0009640 abnormal renal tubule epithelium morphology "any structural anomaly of the cellular avascular layer of the renal tubule luminar surfaces" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il4tm2Nnt/Il4tm2Nnt
Genetic Background: BALB/c-Il4tm2Nnt

 MP:0010173 increased mammary gland epithelium proliferation "increase in the expansion rate of the cells of the mammary gland epithelium by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: GckRgsc702/GckRgsc702
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0011409 increased renal glomerulus basement membrane thickness "increased width of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule" [MGI:anna]
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Allelic Composition: Il4tm2Nnt/Il4tm2Nnt
Genetic Background: BALB/c-Il4tm2Nnt

 MP:0011419 erythrocyturia "presence of red blood cells in the urine" [MGI:anna]
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Allelic Composition: Il4tm2Nnt/Il4tm2Nnt
Genetic Background: BALB/c-Il4tm2Nnt

 MP:0011640 abnormal aorta collagen fibril morphology "any structural anomaly of the connective tissue bundles in the extracellular matrix of aorta tissue that are composed of collagen, and play a role in tissue strength and elasticity" [MGI:csmith]
Show

Allelic Composition: Gria2tm1Lex/Gria2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003534 Ddr1 / Q03146 / Epithelial discoidin domain-containing receptor 1 / Q08345* / discoidin domain receptor tyrosine kinase 1*  / complex






 

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