Manteia - Molecule gene

ENSMUSG00000021464

Mus musculus

Features

Gene ID:	ENSMUSG00000021464

Biological name :	Ror2

Synonyms :	Q9Z138 / receptor tyrosine kinase-like orphan receptor 2 / Ror2

Possible biological names infered from orthology :	Q01974

Species:	Mus musculus

Chr. number:	13
Strand:	-1
Band:	B1
Gene start:	53109312
Gene end:	53286124

Corresponding Affymetrix probe sets:	10409282 (MoGene1.0st) 1423428_at (Mouse Genome 430 2.0 Array) 1457128_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000123362 Ensembl peptide - ENSMUSP00000021918 NCBI entrez gene - 26564 See in Manteia. MGI - MGI:1347521 RefSeq - NM_013846 RefSeq Peptide - NP_038874 swissprot - E9PUN5 swissprot - Q9Z138 Ensembl - ENSMUSG00000021464

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
ror2	ENSDARG00000076227	Danio rerio
ROR2	ENSGALG00000015208	Gallus gallus
ROR2	ENSG00000169071	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Ror1 / Q9Z139 / Inactive tyrosine-protein kinase transmembrane receptor ROR1 / Q01973* / receptor tyrosine kinase like orphan receptor 1*	ENSMUSG00000035305	57
Igf1r / insulin like growth factor 1 receptor / P08069*	ENSMUSG00000005533	19
Musk / Q61006 / Muscle, skeletal receptor tyrosine-protein kinase / O15146* / muscle associated receptor tyrosine kinase*	ENSMUSG00000057280	19
Ntrk2 / P15209 / BDNF/NT-3 growth factors receptor / Q16620* / neurotrophic receptor tyrosine kinase 2*	ENSMUSG00000055254	19
Ntrk3 / Q6VNS1 / NT-3 growth factor receptor / Q16288* / neurotrophic receptor tyrosine kinase 3*	ENSMUSG00000059146	18
Ntrk1 / Q3UFB7 / High affinity nerve growth factor receptor / P04629* / neurotrophic receptor tyrosine kinase 1*	ENSMUSG00000028072	18
Insr / P15208 / Insulin receptor Insulin receptor subunit alpha Insulin receptor subunit beta / P06213* / insulin receptor*	ENSMUSG00000005534	18
Ros1 / Q78DX7 / Proto-onco tyrosine-protein kinase ROS / P08922* / ROS proto-oncogene 1, receptor tyrosine kinase*	ENSMUSG00000019893	18
Alk / P97793 / ALK tyrosine kinase receptor / Q9UM73* / ALK receptor tyrosine kinase*	ENSMUSG00000055471	17
Insrr / Q9WTL4 / Insulin receptor-related protein Insulin receptor-related protein alpha chain Insulin receptor-related protein beta chain / P14616* / insulin receptor related receptor*	ENSMUSG00000005640	17
Ddr2 / Q62371 / Discoidin domain-containing receptor 2 / Q16832* / discoidin domain receptor tyrosine kinase 2*	ENSMUSG00000026674	16
Ltk / P08923 / Leukocyte tyrosine kinase receptor / P29376* / leukocyte receptor tyrosine kinase*	ENSMUSG00000027297	15
Ddr1 / Q03146 / Epithelial discoidin domain-containing receptor 1 / Q08345* / discoidin domain receptor tyrosine kinase 1*	ENSMUSG00000003534	15
Ptk7 / Q8BKG3 / Inactive tyrosine-protein kinase 7 / Q13308* / protein tyrosine kinase 7 (inactive)*	ENSMUSG00000023972	14

Protein motifs (from Interpro)

Interpro ID	Name
IPR000001	Kringle
IPR000719	Protein kinase domain
IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
IPR003598	Immunoglobulin subtype 2
IPR003599	Immunoglobulin subtype
IPR007110	Immunoglobulin-like domain
IPR008266	Tyrosine-protein kinase, active site
IPR011009	Protein kinase-like domain superfamily
IPR013098	Immunoglobulin I-set
IPR013783	Immunoglobulin-like fold
IPR013806	Kringle-like fold
IPR016247	Tyrosine-protein kinase, receptor ROR
IPR018056	Kringle, conserved site
IPR020067	Frizzled domain
IPR036179	Immunoglobulin-like domain superfamily
IPR036790	Frizzled cysteine-rich domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001501	skeletal system development	IMP
biological_process	GO:0001502	cartilage condensation	IMP
biological_process	GO:0001756	somitogenesis	IMP
biological_process	GO:0006468	protein phosphorylation	IEA
biological_process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IEA
biological_process	GO:0007223	Wnt signaling pathway, calcium modulating pathway	IPI
biological_process	GO:0007224	smoothened signaling pathway	IMP
biological_process	GO:0007254	JNK cascade	IDA
biological_process	GO:0007275	multicellular organism development	IEA
biological_process	GO:0008285	negative regulation of cell proliferation	IEA
biological_process	GO:0014002	astrocyte development	IEA
biological_process	GO:0016055	Wnt signaling pathway	IEA
biological_process	GO:0016310	phosphorylation	IEA
biological_process	GO:0018108	peptidyl-tyrosine phosphorylation	IEA
biological_process	GO:0030154	cell differentiation	IMP
biological_process	GO:0030282	bone mineralization	IEA
biological_process	GO:0030335	positive regulation of cell migration	IEA
biological_process	GO:0030509	BMP signaling pathway	IMP
biological_process	GO:0030538	embryonic genitalia morphogenesis	IMP
biological_process	GO:0030539	male genitalia development	IEA
biological_process	GO:0042472	inner ear morphogenesis	IMP
biological_process	GO:0042733	embryonic digit morphogenesis	IMP
biological_process	GO:0043507	positive regulation of JUN kinase activity	IEA
biological_process	GO:0045165	cell fate commitment	IMP
biological_process	GO:0045651	positive regulation of macrophage differentiation	IEA
biological_process	GO:0045893	positive regulation of transcription, DNA-templated	IDA
biological_process	GO:0051968	positive regulation of synaptic transmission, glutamatergic	IEA
biological_process	GO:0060071	Wnt signaling pathway, planar cell polarity pathway	IMP
biological_process	GO:0060395	SMAD protein signal transduction	IMP
biological_process	GO:0060828	regulation of canonical Wnt signaling pathway	IMP
biological_process	GO:0090090	negative regulation of canonical Wnt signaling pathway	IGI
biological_process	GO:0090263	positive regulation of canonical Wnt signaling pathway	IDA
biological_process	GO:1900020	positive regulation of protein kinase C activity	IEA
biological_process	GO:1905517	macrophage migration	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005874	microtubule	IEA
cellular_component	GO:0005886	plasma membrane	TAS
cellular_component	GO:0005887	integral component of plasma membrane	ISS
cellular_component	GO:0009986	cell surface	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0030425	dendrite	IEA
cellular_component	GO:0043025	neuronal cell body	IEA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0004672	protein kinase activity	IEA
molecular_function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	TAS
molecular_function	GO:0005109	frizzled binding	IPI
molecular_function	GO:0005515	protein binding	IEA
molecular_function	GO:0005524	ATP binding	IEA
molecular_function	GO:0016301	kinase activity	IEA
molecular_function	GO:0016740	transferase activity	IEA
molecular_function	GO:0017147	Wnt-protein binding	IEA
molecular_function	GO:0046872	metal ion binding	IEA

Pathways (from Reactome)

Pathway description

WNT5A-dependent internalization of FZD2, FZD5 and ROR2

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000029	abnormal malleus morphology	"structural anomaly in the largest of the three auditory ossicles, which resembles a club or hammer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000042	abnormal organ of Corti	"abnormalities associated with the highly specialized epithelium in the floor of the ductus cochlearis; also referred to a spiral organ (organum spirale), or acoustic papilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd
MP:0000060	delayed bone ossification	"late onset of the formation of bone" [J:40203]	Show Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000088	short mandible	"reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ror2^tm1Anec/Ror2^tm1Anec Genetic Background: B6.129S1-Ror2^tm1Anec
MP:0000102	abnormal nasal bone morphology	"malformed elongated rectangular bone that forms part of the nasal bridge" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]	Show Allelic Composition: Ror2^tm1Anec/Ror2^tm1Anec Genetic Background: B6.129S1-Ror2^tm1Anec
MP:0000111	cleft palate	"congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]	Show Allelic Composition: Lepr^db/Lepr^db Genetic Background: involves: C57BLKS/J
MP:0000137	abnormal vertebrae morphology	"malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Lepr^db/Lepr^db Genetic Background: involves: C57BLKS/J Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ror2^tm1Anec/Ror2^tm1Anec Genetic Background: B6.129S1-Ror2^tm1Anec
MP:0000150	abnormal rib morphology	"malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]	Show Allelic Composition: Igf1r^tm1Arge/Igf1r^tm2Arge,Tg(Camk2a-cre)2Szi/0 Genetic Background: involves: 129S/SvEv * C57BL/6J * CBA
MP:0000154	rib fusion	"appearance of one or more ribs as a single structure" [J:62022, J:62023]	Show Allelic Composition: Lepr^db/Lepr^db Genetic Background: involves: C57BLKS/J Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ror2^tm1Anec/Ror2^tm1Anec Genetic Background: B6.129S1-Ror2^tm1Anec
MP:0000158	absent sternum	"missing long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62577]	Show Allelic Composition: Ror1^tm1Ymi/Ror1^tm1Ymi,Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000163	abnormal cartilage morphology	"anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Igf1r^tm1Arge/Igf1r^tm2Arge,Tg(Camk2a-cre)2Szi/0 Genetic Background: involves: 129S/SvEv * C57BL/6J * CBA Allelic Composition: Ror1^tm1Ymi/Ror1^tm1Ymi,Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000164	abnormal cartilage development	"anomalous formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Igf1r^tm1Arge/Igf1r^tm2Arge,Tg(Camk2a-cre)2Szi/0 Genetic Background: involves: 129S/SvEv * C57BL/6J * CBA Allelic Composition: Ror1^tm1Ymi/Ror1^tm1Ymi,Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ror2^tm1Anec/Ror2^tm1Anec Genetic Background: B6.129S1-Ror2^tm1Anec
MP:0000166	abnormal chondrocyte morphology	"anomalous structure, organization, or differentiation of nondividing cartilage cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]	Show Allelic Composition: Ror1^tm1Ymi/Ror1^tm1Ymi,Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000438	abnormal skull morphology	"anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Igf1r^tm1Arge/Igf1r^tm2Arge,Tg(Camk2a-cre)2Szi/0 Genetic Background: involves: 129S/SvEv * C57BL/6J * CBA
MP:0000441	wide skull		Show Allelic Composition: Igf1r^tm1Arge/Igf1r^tm2Arge,Tg(Camk2a-cre)2Szi/0 Genetic Background: involves: 129S/SvEv * C57BL/6J * CBA
MP:0000445	short snout	"reduced length of the anterior facial part of the muzzle" [J:53370]	Show Allelic Composition: Lepr^db/Lepr^db Genetic Background: involves: C57BLKS/J Allelic Composition: Ror2^tm1Anec/Ror2^tm1Anec Genetic Background: B6.129S1-Ror2^tm1Anec
MP:0000454	abnormal jaw morphology	"malformation of the bony framework of the mouth where the teeth are held" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Igf1r^tm1Arge/Igf1r^tm2Arge,Tg(Camk2a-cre)2Szi/0 Genetic Background: involves: 129S/SvEv * C57BL/6J * CBA
MP:0000455	abnormal maxilla morphology	"malformation of the upper bony framework of the mouth where the superior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Igf1r^tm1Arge/Igf1r^tm2Arge,Tg(Camk2a-cre)2Szi/0 Genetic Background: involves: 129S/SvEv * C57BL/6J * CBA
MP:0000458	abnormal mandible morphology	"malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Igf1r^tm1Arge/Igf1r^tm2Arge,Tg(Camk2a-cre)2Szi/0 Genetic Background: involves: 129S/SvEv * C57BL/6J * CBA
MP:0000547	short limbs	"reduced average length of the extremities" [MGI:CLS, J:61509]	Show Allelic Composition: Lepr^db/Lepr^db Genetic Background: involves: C57BLKS/J Allelic Composition: Ror2^{Tn(pb-ZG-s)1.1Mrc}/Ror2^{Tn(pb-ZG-s)1.1Mrc} Genetic Background: involves: C57BL/6J Allelic Composition: Ror2^tm1.2Meg/Ror2^tm1.2Meg Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N Allelic Composition: Ror1^tm1.2Meg/Ror1^tm1.2Meg,Ror2^tm1.2Meg/Ror2^tm1.2Meg Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
MP:0000552	abnormal radius morphology	"malformation of the short bone of the lateral forearm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Lepr^db/Lepr^db Genetic Background: involves: C57BLKS/J
MP:0000558	abnormal tibia morphology	"atructural anomaly of the medial and larger of the two bones of the lower leg" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Lepr^db/Lepr^db Genetic Background: involves: C57BLKS/J
MP:0000559	abnormal femur morphology	"structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Lepr^db/Lepr^db Genetic Background: involves: C57BLKS/J
MP:0000562	polydactyly	"greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000572	abnormal autopod morphology	"malformation of the hand or foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Igf1r^tm1Arge/Igf1r^tm2Arge,Tg(Camk2a-cre)2Szi/0 Genetic Background: involves: 129S/SvEv * C57BL/6J * CBA
MP:0000585	kinked tail	"a sharp bend or zig-zag in the tail" [J:61295]	Show Allelic Composition: Ror2^tm1Anec/Ror2^tm1Anec Genetic Background: B6.129S1-Ror2^tm1Anec
MP:0000592	short tail	"reduced length of tail compared to control " [J:55583]	Show Allelic Composition: Lepr^db/Lepr^db Genetic Background: involves: C57BLKS/J Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ror2^{Tn(pb-ZG-s)1.1Mrc}/Ror2^{Tn(pb-ZG-s)1.1Mrc} Genetic Background: involves: C57BL/6J
MP:0000914	exencephaly	"neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]	Show Allelic Composition: Ror1^tm1.2Meg/Ror1^tm1.2Meg,Ror2^tm1.2Meg/Ror2^tm1.2Meg Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
MP:0001153	small seminiferous tubules	"reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]	Show Allelic Composition: Ror2^tm1Anec/Ror2^tm1Anec Genetic Background: B6.129S1-Ror2^tm1Anec
MP:0001258	decreased body length	"decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Ror2^tm1Anec/Ror2^tm1Anec Genetic Background: B6.129S1-Ror2^tm1Anec
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Ror2^tm1Anec/Ror2^tm1Anec Genetic Background: B6.129S1-Ror2^tm1Anec
MP:0001300	ocular hypertelorism	"increased distance between the eyes " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001349	excessive tearing	"an unusually high amount of fluid secreted by the lacrimal glands, often resulting in overflow of fluid from the eye" [hdene:Howard Dene, Mouse Genome Informatics Curator, J:38104]	Show Allelic Composition: Ror2^tm1Anec/Ror2^tm1Anec Genetic Background: B6.129S1-Ror2^tm1Anec
MP:0001575	cyanosis	"a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]	Show Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001688	abnormal somite development	"anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001691	abnormal somite shape	"atypical characteristic surface configuration of a segmental mass along the notochord of the developing embryo" [J:37888]	Show Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001698	reduced embryo size	"smaller proportions of embryo compared to littermates" [J:61790]	Show Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001919	abnormal reproductive system physiology	"anomaly in the function of the organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor⁺,Tacc3^tm1.1Tno/Tacc3⁺,Trp53^tm1Tyj/Trp53^tm1Tyj Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
MP:0001922	reduced male fertility	"reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]	Show Allelic Composition: Ror2^tm1Anec/Ror2^tm1Anec Genetic Background: B6.129S1-Ror2^tm1Anec
MP:0001923	reduced female fertility	"reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Pgr^tm2(cre)Lyd/Pgr⁺,Ror1^tm1.1Meg/Ror1^tm1.1Meg,Ror2^tm1.1Meg/Ror2^tm1.1Meg Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
MP:0001935	reduced litter size	"fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Hcfc1^tm1Lwh/Hcfc1^tm1Lwh,Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ Genetic Background: involves: C57BL/6 * CBA
MP:0001954	respiratory distress	"physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]	Show Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002081	perinatal lethality	"death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor⁺,Tacc3^tm1.1Tno/Tacc3⁺,Trp53^tm1Tyj/Trp53^tm1Tyj Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
MP:0002109	abnormal limb morphology	"abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Igf1r^tm1Arge/Igf1r^tm2Arge,Tg(Camk2a-cre)2Szi/0 Genetic Background: involves: 129S/SvEv * C57BL/6J * CBA Allelic Composition: Ror2^tm1Anec/Ror2^tm1Anec Genetic Background: B6.129S1-Ror2^tm1Anec
MP:0002110	abnormal digit morphology	"abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Rpl38^Ts/Rpl38⁺ Genetic Background: BALB/c-Rpl38^Ts
MP:0002111	abnormal tail morphology	"abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lepr^db/Lepr^db Genetic Background: involves: C57BLKS/J
MP:0002113	abnormal skeleton development	"anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lepr^db/Lepr^db Genetic Background: involves: C57BLKS/J Allelic Composition: Ror2^tm1Anec/Ror2^tm1Anec Genetic Background: B6.129S1-Ror2^tm1Anec
MP:0002114	abnormal axial skeleton morphology	"abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ror2^tm1Anec/Ror2^tm1Anec Genetic Background: B6.129S1-Ror2^tm1Anec
MP:0002187	abnormal fibula morphology	"malformation of the lateral and smaller bone of the lower limb" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lepr^db/Lepr^db Genetic Background: involves: C57BLKS/J
MP:0002192	hydrops fetalis	"an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ror1^tm1.2Meg/Ror1^tm1.2Meg,Ror2^tm1.2Meg/Ror2^tm1.2Meg Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
MP:0002216	abnormal seminiferous tubule morphology	"malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ror2^tm1Anec/Ror2^tm1Anec Genetic Background: B6.129S1-Ror2^tm1Anec
MP:0002270	abnormal alveoli morphology	"any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002543	brachyphalangia	"abnormally short phalanges" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ror2^tm1Anec/Ror2^tm1Anec Genetic Background: B6.129S1-Ror2^tm1Anec Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd
MP:0002544	brachydactyly	"abnormally short digits" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Lepr^db/Lepr^db Genetic Background: involves: C57BLKS/J Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ror2^tm1Anec/Ror2^tm1Anec Genetic Background: B6.129S1-Ror2^tm1Anec
MP:0002622	abnormal cochlear hair cell morphology	"malformation of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd
MP:0002687	oligozoospermia	"reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]	Show Allelic Composition: Ror2^tm1Anec/Ror2^tm1Anec Genetic Background: B6.129S1-Ror2^tm1Anec
MP:0002759	abnormal caudal vertebrae morphology	"malformed bony segments of the tail, usually 27-30 present" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82849]	Show Allelic Composition: Lepr^db/Lepr^db Genetic Background: involves: C57BLKS/J Allelic Composition: Ror2^tm1Anec/Ror2^tm1Anec Genetic Background: B6.129S1-Ror2^tm1Anec
MP:0002764	short tibia	" reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Lepr^db/Lepr^db Genetic Background: involves: C57BLKS/J
MP:0002765	short fibula	"reduced length of the lateral and smaller of bone of the lower leg" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:12736]	Show Allelic Composition: Lepr^db/Lepr^db Genetic Background: involves: C57BLKS/J
MP:0002896	abnormal bone mineralization	"defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ror2^tm1Anec/Ror2^tm1Anec Genetic Background: B6.129S1-Ror2^tm1Anec
MP:0002982	abnormal germ cell migration	"defects in the orderly movement of a germ cell, a cell specialized to produce haploid gametes, from one site to another during development" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]	Show Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ror2^Y324C/Ror2^Y324C Genetic Background: involves: C57BL/6J Allelic Composition: Bax^tm1Sjk/Bax^tm1Sjk,Ror2^Y324C/Ror2^Y324C Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0003047	abnormal thoracic vertebrae morphology	"malformation of any or all of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Ror2^tm1Anec/Ror2^tm1Anec Genetic Background: B6.129S1-Ror2^tm1Anec
MP:0003050	abnormal sacral vertebrae morphology	"malformation of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003055	abnormal epiphyseal plate morphology	"malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Lepr^db/Lepr^db Genetic Background: involves: C57BLKS/J
MP:0003109	short femur	"reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Lepr^db/Lepr^db Genetic Background: involves: C57BLKS/J
MP:0003408	increased width of hypertrophic chondrocyte zone	"increased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Lepr^db/Lepr^db Genetic Background: involves: C57BLKS/J
MP:0003409	decreased width of hypertrophic chondrocyte zone	"decreased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003419	delayed endochondral bone ossification	"late onset of bone formation in bones that form from cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]	Show Allelic Composition: Lepr^db/Lepr^db Genetic Background: involves: C57BLKS/J Allelic Composition: Ror2^tm1Anec/Ror2^tm1Anec Genetic Background: B6.129S1-Ror2^tm1Anec
MP:0003662	abnormal proliferative zone	"germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]	Show Allelic Composition: Lepr^db/Lepr^db Genetic Background: involves: C57BLKS/J Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003723	abnormal long bone morphology	"malformation of any of the several elongated bones of the extremities " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Lepr^db/Lepr^db Genetic Background: involves: C57BLKS/J Allelic Composition: Ror1^tm1Ymi/Ror1^tm1Ymi,Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003743	abnormal facial morphology	"anomalous structure or development of the face" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Ror2^tm1.2Meg/Ror2^tm1.2Meg Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N Allelic Composition: Ror1^tm1.2Meg/Ror1^tm1.2Meg,Ror2^tm1.2Meg/Ror2^tm1.2Meg Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
MP:0003854	abnormal forelimb stylopod morphology		Show Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003855	abnormal forelimb zeugopod morphology		Show Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003856	abnormal hindlimb stylopod morphology		Show Allelic Composition: Lepr^db/Lepr^db Genetic Background: involves: C57BLKS/J Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003857	abnormal hindlimb zeugopod morphology		Show Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003935	abnormal craniofacial development	"anomaly in the process of forming the face and/or cranium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003960	increased lean body mass	"more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]	Show Allelic Composition: Ror2^tm1Anec/Ror2^tm1Anec Genetic Background: B6.129S1-Ror2^tm1Anec
MP:0004073	caudal body truncation	"caudal part of body truncated with anterior portion relatively normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ror2^tm1.2Meg/Ror2^tm1.2Meg Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N Allelic Composition: Ror1^tm1.2Meg/Ror1^tm1.2Meg,Ror2^tm1.2Meg/Ror2^tm1.2Meg Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
MP:0004110	transposition of great arteries	"cardiovascular malformation in which the aorta arises from the right ventricle while the pulmonary artery arises from the left ventricle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ror1^tm1Ymi/Ror1^tm1Ymi,Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004173	abnormal intervertebral disk morphology	"malformation of the cartilagenous and gelatinous structure found between vertebrae" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Ror2^tm1Anec/Ror2^tm1Anec Genetic Background: B6.129S1-Ror2^tm1Anec
MP:0004256	abnormal maternal decidual layer morphology	"anomaly in the structure of the maternal uterine-derived portion of the placenta" [PMID:11433360]	Show Allelic Composition: Pgr^tm2(cre)Lyd/Pgr⁺,Ror1^tm1.1Meg/Ror1^tm1.1Meg,Ror2^tm1.1Meg/Ror2^tm1.1Meg Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
MP:0004351	short humerus	"reduced length of one or both of the bones of the forelimb that articulates with the scapula above and the radius and ulna below" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Lepr^db/Lepr^db Genetic Background: involves: C57BLKS/J
MP:0004355	short radius	"reduced length of the short bone of the lateral forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Lepr^db/Lepr^db Genetic Background: involves: C57BLKS/J Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004359	short ulna	"reduced length of the medial and larger of the two bones of the forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Lepr^db/Lepr^db Genetic Background: involves: C57BLKS/J Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004399	abnormal cochlear outer hair cell morphology	"any structural abnormality in the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there are three rows of columnar outer hair cells largely surrounded by cortilymph and supporting phalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a V-shaped pattern extend from the cell s surface through the cuticular plate into the tectorial membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd
MP:0004471	short nasal bone	"reduced length of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Lepr^db/Lepr^db Genetic Background: involves: C57BLKS/J Allelic Composition: Ror2^tm1Anec/Ror2^tm1Anec Genetic Background: B6.129S1-Ror2^tm1Anec
MP:0004472	broad nasal bone	"increased width of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Ror2^tm1Anec/Ror2^tm1Anec Genetic Background: B6.129S1-Ror2^tm1Anec
MP:0004506	abnormal pubic bone morphology	"any structural anomaly in the forward portion of either of the hipbones, at the juncture forming the front arch of the pelvis" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ror1^tm1Ymi/Ror1^tm1Ymi,Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004595	abnormal mandibular condyloid process morphology	"any structural anomaly of the round bump of bone and constricted neck portion that arises from the upper surface of the mandibular ramus (perpendicular portion) and articulates with the articular disk of the temporomandibular joint" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004596	abnormal mandibular angle morphology	"any structural anomaly of the portion of the mandible where the body of the mandible (horizontal portion) and the rami (perpendicular portions) meet; these normally unite nearly at right angles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004619	caudal vertebral fusion	"the union of one or more caudal vertebrae into a single structure in species where this does not normally occur" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ror2^tm1Anec/Ror2^tm1Anec Genetic Background: B6.129S1-Ror2^tm1Anec
MP:0004622	sacral vertebral fusion	"the union of one or more sacral vertebrae into a single structure in species where this does not normally occur" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004634	short metacarpal bones	"reduced length of the five bones of the forepaws that articulate proximally with the carpal bones and distally with the phalanges" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ror2^tm1Anec/Ror2^tm1Anec Genetic Background: B6.129S1-Ror2^tm1Anec
MP:0004652	small caudal vertebrae	"reduced size of the bony segments of the coccyx or tail; there are usually 27-30 present in rodents and only 3-5 fused vertebrae in human" [MESH:National Library of Medicine_Medical Subject Headings]	Show Allelic Composition: Lepr^db/Lepr^db Genetic Background: involves: C57BLKS/J
MP:0004657	small sacral vertebrae	"reduced size of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]	Show Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004667	vertebral body hypoplasia	"underdevelopment or reduced size, usually due to a reduced number of cells, of the main cylindrical portion of the vertebra ventral to the vertebral canal" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Ror2^tm1Anec/Ror2^tm1Anec Genetic Background: B6.129S1-Ror2^tm1Anec
MP:0004686	decreased length of long bones	"reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004703	abnormal vertebral column	"any structural anomaly of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lepr^db/Lepr^db Genetic Background: involves: C57BLKS/J
MP:0004708	short lumbar vertebrae	"reduced length of any or all of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lepr^db/Lepr^db Genetic Background: involves: C57BLKS/J
MP:0004726	abnormal nasal capsule morphology	"any structural abnormality in the cartilage around the developing nasal cavity of the embryo" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004852	decreased testis weight	"reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ror2^tm1Anec/Ror2^tm1Anec Genetic Background: B6.129S1-Ror2^tm1Anec
MP:0005105	abnormal middle ear ossicle morphology	"anomalous structure or development of the three small bones of the middle ear" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0005108	abnormal ulna morphology	"malformation of the medial and larger of the two bones of the forearm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132]	Show Allelic Composition: Lepr^db/Lepr^db Genetic Background: involves: C57BLKS/J
MP:0005222	abnormal somite size	"atypical size of any of the segmental masses along the notochord of the developing embryo" [J:72325]	Show Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0005225	abnormal vertebrae development	"anomalous formation of the vertebrae from the sclerotome" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0005296	abnormal humerus morphology	"malformation of the bone of the forelimb that articulates with the scapula above and the radius and ulna below" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Lepr^db/Lepr^db Genetic Background: involves: C57BLKS/J
MP:0005306	abnormal phalanx morphology	"aberrant structure of any of the long bones of the digits" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Lepr^db/Lepr^db Genetic Background: involves: C57BLKS/J Allelic Composition: Ror2^tm1Anec/Ror2^tm1Anec Genetic Background: B6.129S1-Ror2^tm1Anec
MP:0005508	abnormal skeleton morphology	"malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ror2^{Tn(pb-ZG-s)1.1Mrc}/Ror2^{Tn(pb-ZG-s)1.1Mrc} Genetic Background: involves: C57BL/6J
MP:0005587	abnormal Meckel s cartilage morphology	"structural anomaly of this cartilage bar in the mandibular arch that forms a temporary supporting structure in the embryonic mandible; gives rise to middle ear bones and sphenomandibular and anterior malleolar ligaments" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17694]	Show Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0006165	entropion	"abnormal inward rolling of the eyelid, most commonly the lower lid" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Ror2^tm1Anec/Ror2^tm1Anec Genetic Background: B6.129S1-Ror2^tm1Anec
MP:0006212	large orbits	"increased size of the orbits" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Ror2^tm1Anec/Ror2^tm1Anec Genetic Background: B6.129S1-Ror2^tm1Anec
MP:0006279	abnormal limb development	"anomaly in the formation of the limbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lepr^db/Lepr^db Genetic Background: involves: C57BLKS/J Allelic Composition: Ror2^tm1Anec/Ror2^tm1Anec Genetic Background: B6.129S1-Ror2^tm1Anec
MP:0006280	abnormal digit development	"anomaly in the formation of the digits" [J:70592, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lepr^db/Lepr^db Genetic Background: involves: C57BLKS/J Allelic Composition: Ror2^tm1Anec/Ror2^tm1Anec Genetic Background: B6.129S1-Ror2^tm1Anec
MP:0006281	abnormal tail development	"anomaly in the formation of the tail" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ror2^Y324C/Ror2^Y324C Genetic Background: involves: C57BL/6J
MP:0008272	abnormal endochondral bone ossification	"anomaly in the process of the formation of bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958]	Show Allelic Composition: Lepr^db/Lepr^db Genetic Background: involves: C57BLKS/J
MP:0008391	abnormal primordial germ cell morphology	"any structural anomaly of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Bax^tm1Sjk/Bax^tm1Sjk,Ror2^Y324C/Ror2^Y324C Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0008392	decreased primordial germ cell number	"reduced number of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ror2^Y324C/Ror2^Y324C Genetic Background: involves: C57BL/6J Allelic Composition: Bax^tm1Sjk/Bax^tm1Sjk,Ror2^Y324C/Ror2^Y324C Genetic Background: involves: 129X1/SvJ * C57BL/6J
MP:0008786	abnormal hindgut morphology	"any structural anomaly of the caudal portion of the primitive digestive tube of the embryo" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ror2^Y324C/Ror2^Y324C Genetic Background: involves: C57BL/6J
MP:0009284	abnormal sympathetic neuron innervation	"defective or incomplete supply of nerve fibers to sympathetic termini" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ror1^tm1.2Meg/Ror1^tm1.2Meg,Ror2^tm1.2Meg/Ror2^tm1.2Meg Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
MP:0009642	abnormal blood homeostasis	"anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0009666	abnormal embryo attachment	"any anomaly in the process whereby the blastocyst anchors to the uterine luminal epithelium and cannot be dislodged by flushing" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:10882512 "Carson DD, et al, Embryo implantation Dev Biol. 2000 Jul 15;223(2):217-37."]	Show Allelic Composition: Pgr^tm2(cre)Lyd/Pgr⁺,Ror1^tm1.1Meg/Ror1^tm1.1Meg,Ror2^tm1.1Meg/Ror2^tm1.1Meg Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
MP:0009703	decreased birth body size	"reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ror2^{Tn(pb-ZG-s)1.1Mrc}/Ror2^{Tn(pb-ZG-s)1.1Mrc} Genetic Background: involves: C57BL/6J
MP:0009768	impaired somite development	"atypical process of somite formation with the result of fewer or none of these cell masses being formed" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ror2^Y324C/Ror2^Y324C Genetic Background: involves: C57BL/6J
MP:0009886	failure of palatal shelf elevation	"the palatal shelves fail to move from a vertical position in the orofacial cavity to a horizontal apposition above the developing tongue" [PMID:16680722]	Show Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0009890	cleft secondary palate	"congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]	Show Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0010025	decreased total body fat amount	"less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ror2^tm1Anec/Ror2^tm1Anec Genetic Background: B6.129S1-Ror2^tm1Anec
MP:0010402	ventricular septal defect	"abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]	Show Allelic Composition: Ror1^tm1Ymi/Ror1^tm1Ymi,Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0010418	perimembraneous ventricular septal defect	"abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com]	Show Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0010869	decreased bone trabecula number	"decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ror2^tm1Anec/Ror2^tm1Anec Genetic Background: B6.129S1-Ror2^tm1Anec
MP:0010879	decreased trabecular bone volume	"decrease in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ror2^tm1Anec/Ror2^tm1Anec Genetic Background: B6.129S1-Ror2^tm1Anec
MP:0011087	complete neonatal lethality	"death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011089	complete perinatal lethality	"death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Lepr^db/Lepr^db Genetic Background: involves: C57BLKS/J
MP:0011090	partial perinatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Ror1^tm1Ymi/Ror1^tm1Ymi,Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011099	complete lethality throughout fetal growth and development	"death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Ror1^tm1.2Meg/Ror1^tm1.2Meg,Ror2^tm1.2Meg/Ror2^tm1.2Meg Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
MP:0011610	abnormal primordial germ cell apoptosis	"change in the timing or the number of primordial germ cells undergoing programmed cell death" [MGI:smb]	Show Allelic Composition: Ror2^Y324C/Ror2^Y324C Genetic Background: involves: C57BL/6J
MP:0011772	genital tubercle hypoplasia	"underdevelopment or reduced size of the embryonic anlage of the external genitalia, usually due to a reduced number of cells" [MGI:anna]	Show Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0012062	small tail bud	"decreased size or area of the primordial region of the embryo that arises to form the tail of the adult" [MGI:anna]	Show Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0012085	midface hypoplasia	"underdevelopment of the midfacial region comprising the nasal, maxillary, and zygomatic bones, leading to a concave-looking face" [MGI:anna]	Show Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0013933	short Meckel s cartilage		Show Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0014106	delayed chondrocyte differentiation	"delay in the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte" [GO:0002062]	Show Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0030321	abnormal tegmen tympani morphology	"any structural anomaly of the thin plate of bone which separates the middle ear (tympanic) cavity from the dura of the middle cranial fossa and forms the roof of the middle ear cavity; it is formed in part by the petrous portion of the temporal bone, and the squamous portion of the temporal bone" [http://www.drtbalu.com/anat_middleear.html, https://medical-dictionary.thefreedictionary.com/tegmen+tympani]	Show Allelic Composition: Ror2^tm1Ymi/Ror2^tm1Ymi Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000021994	Wnt5a / P22725 / wingless-type MMTV integration site family, member 5A / P41221* / Wnt family member 5A*	/ reaction / complex
ENSMUSG00000026556	Q91ZD4 / Vangl2 / VANGL planar cell polarity 2 / Q9ULK5* / VANGL planar cell polarity protein 2*	/ reaction / complex

1 s.

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