ENSMUSG00000005534


Mus musculus

Features
Gene ID: ENSMUSG00000005534
  
Biological name :Insr
  
Synonyms : Insr / Insulin receptor Insulin receptor subunit alpha Insulin receptor subunit beta / P15208
  
Possible biological names infered from orthology : insulin receptor / P06213
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: A1.1
Gene start: 3122061
Gene end: 3279617
  
Corresponding Affymetrix probe sets: 10576692 (MoGene1.0st)   10576696 (MoGene1.0st)   1421380_at (Mouse Genome 430 2.0 Array)   1434446_at (Mouse Genome 430 2.0 Array)   1446673_at (Mouse Genome 430 2.0 Array)   1450225_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000146651
Ensembl peptide - ENSMUSP00000146818
Ensembl peptide - ENSMUSP00000088837
NCBI entrez gene - 16337     See in Manteia.
MGI - MGI:96575
RefSeq - XM_006508699
RefSeq - XM_006508700
RefSeq - XM_006508701
RefSeq - NM_010568
RefSeq Peptide - NP_034698
swissprot - P15208
swissprot - A0A140LI30
swissprot - B8Q3N4
Ensembl - ENSMUSG00000005534
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 insraENSDARG00000011948Danio rerio
 insrbENSDARG00000071524Danio rerio
 INSRENSGALG00000040758Gallus gallus
 INSRENSG00000171105Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Igf1r / insulin like growth factor 1 receptor / P08069*ENSMUSG0000000553356
Insrr / Q9WTL4 / Insulin receptor-related protein Insulin receptor-related protein alpha chain Insulin receptor-related protein beta chain / P14616* / insulin receptor related receptor*ENSMUSG0000000564050
Ros1 / Q78DX7 / Proto-onco tyrosine-protein kinase ROS / P08922* / ROS proto-oncogene 1, receptor tyrosine kinase*ENSMUSG0000001989321
Alk / P97793 / ALK tyrosine kinase receptor / Q9UM73* / ALK receptor tyrosine kinase*ENSMUSG0000005547118
Ntrk2 / P15209 / BDNF/NT-3 growth factors receptor / Q16620* / neurotrophic receptor tyrosine kinase 2*ENSMUSG0000005525415
Ntrk1 / Q3UFB7 / High affinity nerve growth factor receptor / P04629* / neurotrophic receptor tyrosine kinase 1*ENSMUSG0000002807215
Musk / Q61006 / Muscle, skeletal receptor tyrosine-protein kinase / O15146* / muscle associated receptor tyrosine kinase*ENSMUSG0000005728015
Ntrk3 / Q6VNS1 / NT-3 growth factor receptor / Q16288* / neurotrophic receptor tyrosine kinase 3*ENSMUSG0000005914615
Ddr2 / Q62371 / Discoidin domain-containing receptor 2 / Q16832* / discoidin domain receptor tyrosine kinase 2*ENSMUSG0000002667414
Ltk / P08923 / Leukocyte tyrosine kinase receptor / P29376* / leukocyte receptor tyrosine kinase*ENSMUSG0000002729714
Ror1 / Q9Z139 / Inactive tyrosine-protein kinase transmembrane receptor ROR1 / Q01973* / receptor tyrosine kinase like orphan receptor 1*ENSMUSG0000003530513
Ddr1 / Q03146 / Epithelial discoidin domain-containing receptor 1 / Q08345* / discoidin domain receptor tyrosine kinase 1*ENSMUSG0000000353413
Ror2 / Q9Z138 / receptor tyrosine kinase-like orphan receptor 2 / Q01974*ENSMUSG0000002146412
Ptk7 / Q8BKG3 / Inactive tyrosine-protein kinase 7 / Q13308* / protein tyrosine kinase 7 (inactive)*ENSMUSG0000002397212


Protein motifs (from Interpro)
Interpro ID Name
 IPR000494  Receptor L-domain
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR002011  Tyrosine-protein kinase, receptor class II, conserved site
 IPR003961  Fibronectin type III
 IPR006211  Furin-like cysteine-rich domain
 IPR006212  Furin-like repeat
 IPR008266  Tyrosine-protein kinase, active site
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR016246  Tyrosine-protein kinase, insulin-like receptor
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR028792  Insulin receptor-related protein
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036116  Fibronectin type III superfamily
 IPR036941  Receptor L-domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0003007 heart morphogenesis IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008286 insulin receptor signaling pathway IEA
 biological_processGO:0008544 epidermis development IMP
 biological_processGO:0008584 male gonad development IGI
 biological_processGO:0009887 animal organ morphogenesis IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0019087 transformation of host cell by virus IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IEA
 biological_processGO:0030238 male sex determination IMP
 biological_processGO:0030325 adrenal gland development IGI
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0031017 exocrine pancreas development IMP
 biological_processGO:0032147 activation of protein kinase activity IEA
 biological_processGO:0032148 activation of protein kinase B activity IEA
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IDA
 biological_processGO:0042593 glucose homeostasis IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process IEA
 biological_processGO:0045725 positive regulation of glycogen biosynthetic process IEA
 biological_processGO:0045740 positive regulation of DNA replication IEA
 biological_processGO:0045821 positive regulation of glycolytic process IEA
 biological_processGO:0045840 positive regulation of mitotic nuclear division IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IGI
 biological_processGO:0045995 regulation of embryonic development IEA
 biological_processGO:0046326 positive regulation of glucose import IEA
 biological_processGO:0046777 protein autophosphorylation ISS
 biological_processGO:0048639 positive regulation of developmental growth IEA
 biological_processGO:0051290 protein heterotetramerization IEA
 biological_processGO:0051446 positive regulation of meiotic cell cycle IGI
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0060267 positive regulation of respiratory burst IEA
 biological_processGO:0071363 cellular response to growth factor stimulus IDA
 biological_processGO:0071469 cellular response to alkaline pH IEA
 biological_processGO:2000194 regulation of female gonad development IGI
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0005899 insulin receptor complex IEA
 cellular_componentGO:0005901 caveola IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031981 nuclear lumen IEA
 cellular_componentGO:0043235 receptor complex IEA
 cellular_componentGO:0106003 amyloid-beta complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001540 amyloid-beta binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity ISO
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0004716 obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity IEA
 molecular_functionGO:0005009 insulin-activated receptor activity IEA
 molecular_functionGO:0005159 insulin-like growth factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding ISO
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0031994 insulin-like growth factor I binding IEA
 molecular_functionGO:0031995 insulin-like growth factor II binding IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0043548 phosphatidylinositol 3-kinase binding ISS
 molecular_functionGO:0043559 insulin binding IEA
 molecular_functionGO:0043560 insulin receptor substrate binding ISO
 molecular_functionGO:0044877 protein-containing complex binding IEA
 molecular_functionGO:0051425 PTB domain binding IEA


Pathways (from Reactome)
Pathway description
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
IRS activation
Signal attenuation
Insulin receptor signalling cascade
Signaling by Insulin receptor
Insulin receptor recycling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000008 increased white fat amount "increased quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccd/Ccd+,ShhDsh/Shh+
Genetic Background: involves: 101 * C3H * C57BL * C57BL/10Rl * SEC

 MP:0000188 abnormal circulating glucose level "anomalous concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Insrtm1Dac/Insr+
Genetic Background: involves: 129 * C57BL/6J

 MP:0000199 abnormal circulating albumin level "aberrant concentration in the blood of this most abundant of the plasma proteins " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2 * FVB

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Igf1rtm1.1Mhz/Igf1rtm1.1Mhz,Insrtm1Khn/Insrtm1Khn,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Igf1rtm1.1Mhz/Igf1rtm1.1Mhz,Insrtm1Khn/Insrtm1Khn,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Rgs2tm1Pngr/Rgs2+
Genetic Background: involves: C57BL/6J

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Insrtm1Dac/Insrtm1Dac,Tg(TTR-INSR)L2Dac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Insrtm1Dac/Insrtm1Dac,Tg(TTR-INSR)L3Dac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0000601 small liver "reduced size of the liver" [J:23170]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2 * FVB

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2 * FVB

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2 * FVB

Allelic Composition: Insrtm1Shs/Insr+
Genetic Background: involves: C57BL/6CrSlc

Allelic Composition: Insrtm1Dac/Insrtm1Dac,Tg(TTR-INSR)L2Dac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Insrtm1Dac/Insrtm1Dac,Tg(TTR-INSR)L3Dac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0001129 impaired ovarian folliculogenesis "a block in the formation of the spherical ovum in the ovary" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL

 MP:0001134 absent corpora lutea "missing yellow endocrine body formed in the ovary after follicle rupture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: T24H/T+,th2/t+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Ccd/Ccd+,ShhDsh/Shh+
Genetic Background: involves: 101 * C3H * C57BL * C57BL/10Rl * SEC

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Ccd/Ccd+,ShhDsh/Shh+
Genetic Background: involves: 101 * C3H * C57BL * C57BL/10Rl * SEC

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Igf1rtm1.1Mhz/Igf1rtm1.1Mhz,Insrtm1Khn/Insrtm1Khn,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Insrtm1Jja/Insrtm1Jja,Tg(PAH-INSR)1Rjv/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * DBA/2

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Slc2a4-cre)546Dac/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Hsd11b1tm1.1Ggla/Hsd11b1tm1.1Ggla
Genetic Background: involves: 129P2/OlaHsd

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Igf1rtm1.2Mhz/Igf1rtm1.2Mhz
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

Allelic Composition: Igf1rtm1.1Mhz/Igf1rtm1.1Mhz,Insrtm1Khn/Insrtm1Khn,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB

 MP:0001426 polydipsia "excessive thirst that is relatively prolonged" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0001433 polyphagia "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccd/Ccd+,ShhDsh/Shh+
Genetic Background: involves: 101 * C3H * C57BL * C57BL/10Rl * SEC

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Insrtm1Jja/Insrtm1Jja
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Slc2a4-cre)546Dac/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Insrtm1Jja/Insrtm1Jja
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Insrtm1Khn/Insrtm1Dac,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB

Allelic Composition: Insrtm1Dac/Insrtm1Dac,Insrrtm1Dac/Insrrtm1Dac
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6J

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2 * FVB

Allelic Composition: Insrtm1Shs/Insr+
Genetic Background: involves: C57BL/6CrSlc

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: InsrRgsc294/Insr+
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

Allelic Composition: InsrRgsc824/Insr+
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

Allelic Composition: InsrRgsc1777/Insr+
Genetic Background: involves: C3H * C57BL/6JJcl

Allelic Composition: Insrtm1Dac/Insrtm1Dac,Tg(TTR-INSR)L3Dac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Slc2a4-cre)546Dac/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Leprtm1.1Chua/Leprtm1.1Chua,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0001560 abnormal circulating insulin level "anomalous blood concentration of this polypeptide hormone, secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Insrtm1Dac/Insr+
Genetic Background: involves: 129 * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2 * FVB

Allelic Composition: Insrtm1Shs/Insrtm1Shs
Genetic Background: involves: C57BL/6CrSlc

Allelic Composition: Igf1rtm1.1Mhz/Igf1rtm1.1Mhz,Insrtm1Khn/Insrtm1Khn,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Insrtm1Dac/Insrtm1Dac,Tg(TTR-INSR)L2Dac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Insrtm1Dac/Insrtm1Dac,Tg(TTR-INSR)L3Dac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Slc2a4-cre)546Dac/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB

 MP:0001759 increased urine glucose level "a greater level of excretion of glucose in the urine compared to the normal state" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: InsrRgsc294/Insr+
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

Allelic Composition: InsrRgsc824/Insr+
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

Allelic Composition: Insrtm1Jja/Insrtm1Jja,Tg(PAH-INSR)1Rjv/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * DBA/2

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Insrtm1Dac/Insrtm1Dac,Tg(TTR-INSR)L2Dac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Insrtm1Dac/Insrtm1Dac,Tg(TTR-INSR)L3Dac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Leprtm1.1Chua/Leprtm1.1Chua,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0001868 ovary inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the ovary" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Leprtm1.1Chua/Leprtm1.1Chua,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Insrtm1Dac/Insrtm1Dac,Tg(TTR-INSR)L2Dac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Insrtm1Dac/Insrtm1Dac,Tg(TTR-INSR)L3Dac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0001951 abnormal breathing "irregular or atypical breathing pattern " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Igf1rtm1.2Mhz/Igf1rtm1.2Mhz
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

Allelic Composition: Igf1rtm1.1Mhz/Igf1rtm1.1Mhz,Insrtm1Khn/Insrtm1Khn,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2 * FVB

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Insrtm1Dac/Insr+,Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Slc2a4-cre)546Dac/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Insrtm1Jja/Insrtm1Jja
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Insrtm1Khn/Insrtm1Dac,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB

Allelic Composition: Insrtm1Dac/Insrtm1Dac,Insrrtm1Dac/Insrrtm1Dac
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6J

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2 * FVB

Allelic Composition: Insrtm1Shs/Insr+
Genetic Background: involves: C57BL/6CrSlc

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Insrtm1Dac/Insr+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: InsrRgsc294/Insr+
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

Allelic Composition: InsrRgsc824/Insr+
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

Allelic Composition: InsrRgsc1777/Insr+
Genetic Background: involves: C3H * C57BL/6JJcl

Allelic Composition: Insrtm1Dac/Insr+
Genetic Background: involves: C3H/HeH * C57BL/6

Allelic Composition: Insrtm1Dac/Insrtm1Dac,Tg(TTR-INSR)L1Dac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Insrtm1Dac/Insrtm1Dac,Tg(TTR-INSR)L2Dac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Insrtm1Dac/Insrtm1Dac,Tg(TTR-INSR)L3Dac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Actbtm1(INSR)Dac/Actbtm1(INSR)Dac,Insrtm1Dac/Insrtm1Dac,Tg(Camk2a-cre)#Szi/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J * CBA

Allelic Composition: Actbtm1(INSR)Dac/Actbtm1(INSR)Dac,Insrtm1Dac/Insrtm1Dac,Tg(Hsp70-1-cre)6Arge/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Actbtm1(INSR)Dac/Actbtm1(INSR)Dac,Insrtm1Dac/Insrtm1Dac,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Actbtm1(INSR)Dac/Actbtm1(INSR)Dac,Insrtm1Dac/Insrtm1Dac,Tg(Syn1-cre)671Jxm/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Slc2a4-cre)546Dac/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB

Allelic Composition: Foxo1tm2.1Dac/Foxo1tm2.1Dac,Insrtm1Dac/Insr+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Foxo1tm1Whb/Foxo1+,Insrtm1Dac/Insrtm1Dac
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Insrtm1Dac/Insr+,Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Igf1rtm1.2Mhz/Igf1rtm1.2Mhz
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Insrtm1Dac/Insrtm1Dac,Tg(TTR-INSR)L2Dac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Insrtm1Dac/Insrtm1Dac,Tg(TTR-INSR)L3Dac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Actbtm1(INSR)Dac/Actbtm1(INSR)Dac,Insrtm1Dac/Insrtm1Dac,Tg(Camk2a-cre)#Szi/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J * CBA

Allelic Composition: Actbtm1(INSR)Dac/Actbtm1(INSR)Dac,Insrtm1Dac/Insrtm1Dac,Tg(Hsp70-1-cre)6Arge/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Actbtm1(INSR)Dac/Actbtm1(INSR)Dac,Insrtm1Dac/Insrtm1Dac,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Actbtm1(INSR)Dac/Actbtm1(INSR)Dac,Insrtm1Dac/Insrtm1Dac,Tg(Syn1-cre)671Jxm/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2 * FVB

 MP:0002188 small heart "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044]
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Allelic Composition: Igf1rtm1.1Mhz/Igf1rtm1.1Mhz,Insrtm1Khn/Insrtm1Khn,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB

 MP:0002211 abnormal primary sex determination "aberrant gonadal development resulting in either abnormal or absent gonads or the development of gonads inconsistent with the chromosomal sex " [llw2:Linda Washburn , Mouse Genome Informatics Curator, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: T9J/T9J
Genetic Background: C57BL/6J-T9J

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Insrtm1Dac/Insr+,Insrrtm1Dac/Insrrtm1Dac
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129S4/SvJae * C57BL/6J

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccd/Ccd+,ShhDsh/Shh+
Genetic Background: involves: 101 * C3H * C57BL * C57BL/10Rl * SEC

 MP:0002575 increased circulating ketone body level "greater than the normal amount of acetoacetate, 3-hydroxybutyrate and acteone in the blood; produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, J:71968]
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Allelic Composition: Insrtm1Shs/Insrtm1Shs
Genetic Background: involves: C57BL/6CrSlc

Allelic Composition: Actbtm1(INSR)Dac/Actbtm1(INSR)Dac,Insrtm1Dac/Insrtm1Dac
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Insrtm1Jja/Insrtm1Jja
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Insrtm1Jja/Insrtm1Jja,Tg(PAH-INSR)1Rjv/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * DBA/2

Allelic Composition: Insrtm1Dac/Insrtm1Dac,Tg(TTR-INSR)L2Dac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Insrtm1Dac/Insrtm1Dac,Tg(TTR-INSR)L3Dac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Slc2a4-cre)546Dac/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2 * FVB

 MP:0002680 decreased number of corpora lutea "fewer than normal numbers of yellow endocrine body formed in the ovary after follicle rupture in a given oestrus cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2 * FVB

 MP:0002773 decreased circulating luteinizing hormone level "lower than normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35132, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL

 MP:0002777 absent ovarian follicles "lack of the sac-like structures in the ovaries that surround the ova" [J:42612, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Leprtm1.1Chua/Leprtm1.1Chua,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Igf1rtm1.1Mhz/Igf1rtm1.1Mhz,Insrtm1Khn/Insrtm1Khn,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Igf1rtm1.1Mhz/Igf1rtm1.1Mhz,Insrtm1Khn/Insrtm1Khn,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB

 MP:0002865 increased growth rate "accelerated time to reach a developmental stage or stages" [J:32208, il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Insrtm1Dac/Insrtm1Dac,Tg(TTR-INSR)L1Dac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Insrtm1Shs/Insr+
Genetic Background: involves: C57BL/6CrSlc

 MP:0002893 ketoaciduria "excretion of urine having an elevated concentration of keto acids" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Insrtm1Jja/Insrtm1Jja
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Insrtm1Dac/Insrtm1Dac,Insrrtm1Dac/Insrrtm1Dac
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6J

Allelic Composition: Insrtm1Jja/Insrtm1Jja,Tg(PAH-INSR)1Rjv/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * DBA/2

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2 * FVB

 MP:0002971 abnormal brown fat morphology "defect in the thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Slc2a4-cre)546Dac/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB

 MP:0002995 primary sex reversal "gonad type is not consistent with chromosomal sex" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: T9J/T9J
Genetic Background: C57BL/6J-T9J

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Insrtm1Dac/Insr+,Insrrtm1Dac/Insrrtm1Dac
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129S4/SvJae * C57BL/6J

Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Insrtm1Dac/Insrtm1Dac
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6J

 MP:0002996 ovotestis "gonad with both ovarian and testicular tissue" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Igf1rtm1Arge/Igf1rtm1Arge,Insrtm1Dac/Insr+,Insrrtm1Dac/Insrrtm1Dac
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129S4/SvJae * C57BL/6J

 MP:0003058 increased insulin secretion "greater than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2 * FVB

Allelic Composition: Insrtm1Dac/Insr+
Genetic Background: involves: C3H/HeH * C57BL/6

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0003103 liver degeneration "deterioration of the liver due to injury or disease, often accompanied by loss of function" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91653]
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Allelic Composition: Insrtm1Dac/Insrtm1Dac,Tg(TTR-INSR)L2Dac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Insrtm1Dac/Insrtm1Dac,Tg(TTR-INSR)L3Dac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0003339 decreased number of pancreatic beta cells "fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Slc2a4-cre)546Dac/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB

 MP:0003355 reduced ovulation "reduction in the frequency in which an ovum is released from a rupturing ovarian follicle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Leprtm1.1Chua/Leprtm1.1Chua,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0003839 abnormal insulin clearance "increase or decrease in the rate at which insulin is removed from the blood stream" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:99786]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2 * FVB

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Igf1rtm1.1Mhz/Igf1rtm1.1Mhz,Insrtm1Khn/Insrtm1Khn,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB

 MP:0003959 abnormal lean body mass "aberrant fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Slc2a4-cre)546Dac/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Leprtm1.1Chua/Leprtm1.1Chua,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0004565 small myocardial fiber "decreased size of the cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Igf1rtm1.1Mhz/Igf1rtm1.1Mhz,Insrtm1Khn/Insrtm1Khn,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB

 MP:0004789 increased bile salt level "increased concentration of the steroid salts derived from cholesterol in the liver, produced as bile acids and secreted in the biliary sytem as bile salts; these play an important role in the digestion and absorption of fats" [MESH:D04.808.105, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2 * FVB

 MP:0004889 increased energy expenditure "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Insrtm1Dac/Insrtm1Dac,Tg(TTR-INSR)L1Dac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0005215 abnormal islet of Langerhans morphology "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Insrtm1Dac/Insrtm1Dac,Tg(TTR-INSR)L2Dac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Insrtm1Dac/Insrtm1Dac,Tg(TTR-INSR)L3Dac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Slc2a4-cre)546Dac/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Slc2a4-cre)546Dac/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB

 MP:0005281 increased fatty acid level "higher than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Insrtm1Jja/Insrtm1Jja
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Slc2a4-cre)546Dac/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Insrtm1Dac/Insr+
Genetic Background: involves: 129 * C57BL/6J

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Insrtm1Dac/Insrtm1Dac,Insrrtm1Dac/Insrrtm1Dac
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6J

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2 * FVB

Allelic Composition: Insrtm1Shs/Insr+
Genetic Background: involves: C57BL/6CrSlc

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Insrtm1Dac/Insr+,Sox4Igt4/Sox4+
Genetic Background: involves: C3H/HeH * C57BL/6

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Slc2a4-cre)546Dac/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB

 MP:0005317 increased triglyceride level "higher than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB

Allelic Composition: Insrtm1Jja/Insrtm1Jja,Tg(PAH-INSR)1Rjv/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * DBA/2

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2 * FVB

Allelic Composition: Insrtm1Shs/Insr+
Genetic Background: involves: C57BL/6CrSlc

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Insrtm1Dac/Insr+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Gsk3btm1Jrw/Gsk3b+,Insrtm1Dac/Insr+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Slc2a4-cre)546Dac/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB

Allelic Composition: Foxo1tm2.1Dac/Foxo1tm2.1Dac,Insrtm1Dac/Insr+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
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Allelic Composition: Igf1rtm1.1Mhz/Igf1rtm1.1Mhz,Insrtm1Khn/Insrtm1Khn,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB

 MP:0005334 abnormal fat pad "malformed or aberrant size of the encapsulated adipose tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB

 MP:0005335 abnormal gonadal fat pad "malformed or aberrant size of the encapsulated adipose tissue associated with the ovaries or testes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:84541]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Leprtm1.1Chua/Leprtm1.1Chua,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0005336 abnormal inguinal fat pad "malformed or aberrant size of the encapsulated adipose tissue found in the groin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:84541]
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Allelic Composition: Insrtm1Jja/Insrtm1Jja,Tg(PAH-INSR)1Rjv/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * DBA/2

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2 * FVB

 MP:0005439 decreased glycogen level "less than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Insrtm1Jja/Insrtm1Jja
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Insrtm1Jja/Insrtm1Jja,Tg(PAH-INSR)1Rjv/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * DBA/2

 MP:0005458 increased percent body fat "more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Leprtm1.1Chua/Leprtm1.1Chua,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0005491 islet cell hyperplasia "increased numbers cells within the structures that are scattered throughout the pancreas and comprise its endocrine portion" [J:48446, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2 * FVB

 MP:0005536 Leydig cell hypoplasia "reduced numbers of the interstitial cells of the seminiferous tubules that secrete testosterone" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Insrtm1Jja/Insrtm1Jja,Tg(PAH-INSR)1Rjv/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * DBA/2

Allelic Composition: Insrtm1Dac/Insrtm1Dac,Tg(TTR-INSR)L1Dac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Insrtm1Dac/Insrtm1Dac,Tg(TTR-INSR)L2Dac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Insrtm1Dac/Insrtm1Dac,Tg(TTR-INSR)L3Dac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Actbtm1(INSR)Dac/Actbtm1(INSR)Dac,Insrtm1Dac/Insrtm1Dac,Tg(Camk2a-cre)#Szi/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J * CBA

Allelic Composition: Actbtm1(INSR)Dac/Actbtm1(INSR)Dac,Insrtm1Dac/Insrtm1Dac,Tg(Hsp70-1-cre)6Arge/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Actbtm1(INSR)Dac/Actbtm1(INSR)Dac,Insrtm1Dac/Insrtm1Dac,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Actbtm1(INSR)Dac/Actbtm1(INSR)Dac,Insrtm1Dac/Insrtm1Dac,Tg(Syn1-cre)671Jxm/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Slc2a4-cre)546Dac/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxo1tm1Whb/Foxo1+,Insrtm1Dac/Insrtm1Dac
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Igf1rtm1.2Mhz/Igf1rtm1.2Mhz
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

Allelic Composition: Igf1rtm1.1Mhz/Igf1rtm1.1Mhz,Insrtm1Khn/Insrtm1Khn,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB

 MP:0005608 cardiac interstitial fibrosis "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Igf1rtm1.1Mhz/Igf1rtm1.1Mhz,Insrtm1Khn/Insrtm1Khn,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * SJL

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Leprtm1.1Chua/Leprtm1.1Chua,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0006094 adipocyte hypertrophy "increase in the size of fat cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:90802]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Leprtm1.1Chua/Leprtm1.1Chua,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Igf1rtm1.1Mhz/Igf1rtm1.1Mhz,Insrtm1Khn/Insrtm1Khn,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB

 MP:0006319 abnormal epididymal fat pad "any structural anomaly of the encapsulated adipose tissue associated with the epididymis" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Slc2a4-cre)546Dac/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB

 MP:0006353 incleased glycosylated hemoglobin level "greater than normal blood concentration of a modified form of hemoglobin with an attached saccharide molecule " [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator", Riken ENU:Hiroshi Masuya]
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Allelic Composition: InsrRgsc824/Insr+
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0009113 increased pancreatic beta cell mass "greater total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2 * FVB

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Insrtm1Dac/Insr+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Insrtm1Dac/Insrtm1Dac,Tg(TTR-INSR)L2Dac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Insrtm1Dac/Insrtm1Dac,Tg(TTR-INSR)L3Dac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0009114 decreased pancreatic beta cell mass "reduced total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Pdx1tm1Ted/Pdx1+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Gsk3btm1Jrw/Gsk3b+,Insrtm1Dac/Insr+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Insrtm1Dac/Insrtm1Dac,Tg(TTR-INSR)L1Dac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0009124 increased brown fat cell lipid droplet size "increase in the size of the multiple small droplets of triglycerides found in brown adipocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Slc2a4-cre)546Dac/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB

 MP:0009174 absent pancreatic beta cells "absence of the cells of the pancreas that secrete insulin" [MESH:A03.734.414.131]
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Allelic Composition: Insrtm1Dac/Insr+,Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0009342 enlarged gall bladder "increased size of the gall bladder, the organ that serves as a storage reservoir for bile" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2 * FVB

 MP:0009462 skeletal muscle hypotrophy "decrease in the bulk size of the skeletal muscle due to cell shrinkage" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Insrtm1Jja/Insrtm1Jja
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
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Allelic Composition: Insrtm1Dac/Insrtm1Dac,Tg(TTR-INSR)L1Dac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Insrtm1Dac/Insrtm1Dac,Tg(TTR-INSR)L2Dac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Insrtm1Dac/Insrtm1Dac,Tg(TTR-INSR)L3Dac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0009764 decreased sensitivity to induced morbidity/mortality "increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Insrtm1Shs/Insr+
Genetic Background: involves: C57BL/6CrSlc

 MP:0009767 decreased sensitivity to xenobiotic induced morbidity/mortality "increase in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Insrtm1Shs/Insr+
Genetic Background: involves: C57BL/6CrSlc

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Insrtm1Jja/Insrtm1Jja
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Insrtm1Shs/Insr+
Genetic Background: involves: C57BL/6CrSlc

 MP:0010398 decreased liver glycogen level "less than the normal concentration of a readily converted carbohydrate reserve in liver" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Insrtm1Dac/Insrtm1Dac,Tg(TTR-INSR)L2Dac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Insrtm1Dac/Insrtm1Dac,Tg(TTR-INSR)L3Dac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Slc2a4-cre)546Dac/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB

 MP:0010725 thin interventricular septum "decreased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Igf1rtm1.1Mhz/Igf1rtm1.1Mhz,Insrtm1Khn/Insrtm1Khn,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Insrtm1Jja/Insrtm1Jja
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Insrtm1Dac/Insrtm1Dac,Insrrtm1Dac/Insrrtm1Dac
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6J

Allelic Composition: Insrtm1Shs/Insrtm1Shs
Genetic Background: involves: C57BL/6CrSlc

Allelic Composition: Igf1rtm1.1Mhz/Igf1rtm1.1Mhz,Insrtm1Khn/Insrtm1Khn,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Insrtm1Jja/Insrtm1Jja,Tg(PAH-INSR)1Rjv/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * DBA/2

Allelic Composition: Actbtm1(INSR)Dac/Actbtm1(INSR)Dac,Insrtm1Dac/Insrtm1Dac
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0011630 increased mitochondria size "enlarged the cellular organelles responsible for energy production" [MGI:csmith]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2 * FVB

 MP:0011943 abnormal circadian feeding behavior "anomaly in the fluctuation pattern in feeding behavior (amount and instances) that occurs over an approximately 24 hour light/dark cycle" [MGI:csmith]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Slc2a4-cre)546Dac/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB

 MP:0020386 adipose tissue inflammation "local accumulation of fluid, plasma proteins, and leukocytes in adipose tissue" [MGI:anna, PMID:24662293, PMID:24695736, PMID:26629401]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Leprtm1.1Chua/Leprtm1.1Chua,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0020411 increased abdominal adipose tissue amount "increase in amount of adipose tissue associated with internal organs" [MGI:anna]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Leprtm1.1Chua/Leprtm1.1Chua,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000215 Ins2 / P01326 / Insulin-2 Insulin-2 B chain Insulin-2 A chain / INS* / P01308* / insulin*  / reaction / complex
 ENSMUSG00000035804 Ins1 / P01325 / Insulin-1 Insulin-1 B chain Insulin-1 A chain / INS* / P01308* / insulin*  / reaction / complex
 ENSMUSG00000038894 Irs2 / P81122 / Insulin receptor substrate 2 / Q9Y4H2*  / reaction / complex
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / complex / reaction
 ENSMUSG00000055980 Irs1 / insulin receptor substrate 1 / P35568*  / reaction / complex
 ENSMUSG00000020176 Grb10 / Q60760 / Growth factor receptor-bound protein 10 / Q13322*  / complex / reaction
 ENSMUSG00000005534 Insr / P15208 / Insulin receptor Insulin receptor subunit alpha Insulin receptor subunit beta / P06213* / insulin receptor*  / complex






 

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