ENSMUSG00000023972


Mus musculus

Features
Gene ID: ENSMUSG00000023972
  
Biological name :Ptk7
  
Synonyms : Inactive tyrosine-protein kinase 7 / Ptk7 / Q8BKG3
  
Possible biological names infered from orthology : protein tyrosine kinase 7 (inactive) / Q13308
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: C
Gene start: 46564451
Gene end: 46629504
  
Corresponding Affymetrix probe sets: 10451372 (MoGene1.0st)   1452589_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000043703
NCBI entrez gene - 71461     See in Manteia.
MGI - MGI:1918711
RefSeq - XM_017317638
RefSeq - NM_175168
RefSeq - XM_006524923
RefSeq - XM_006524924
RefSeq - XM_006524922
RefSeq Peptide - NP_780377
swissprot - Q8BKG3
Ensembl - ENSMUSG00000023972
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptk7aENSDARG00000011863Danio rerio
 PTK7ENSGALG00000008609Gallus gallus
 PTK7ENSG00000112655Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ros1 / Q78DX7 / Proto-onco tyrosine-protein kinase ROS / P08922* / ROS proto-oncogene 1, receptor tyrosine kinase*ENSMUSG0000001989326
Igf1r / insulin like growth factor 1 receptor / P08069*ENSMUSG0000000553316
Insr / P15208 / Insulin receptor Insulin receptor subunit alpha Insulin receptor subunit beta / P06213* / insulin receptor*ENSMUSG0000000553416
Ntrk1 / Q3UFB7 / High affinity nerve growth factor receptor / P04629* / neurotrophic receptor tyrosine kinase 1*ENSMUSG0000002807216
Insrr / Q9WTL4 / Insulin receptor-related protein Insulin receptor-related protein alpha chain Insulin receptor-related protein beta chain / P14616* / insulin receptor related receptor*ENSMUSG0000000564015
Ntrk3 / Q6VNS1 / NT-3 growth factor receptor / Q16288* / neurotrophic receptor tyrosine kinase 3*ENSMUSG0000005914615
Musk / Q61006 / Muscle, skeletal receptor tyrosine-protein kinase / O15146* / muscle associated receptor tyrosine kinase*ENSMUSG0000005728015
Ntrk2 / P15209 / BDNF/NT-3 growth factors receptor / Q16620* / neurotrophic receptor tyrosine kinase 2*ENSMUSG0000005525414
Alk / P97793 / ALK tyrosine kinase receptor / Q9UM73* / ALK receptor tyrosine kinase*ENSMUSG0000005547114
Ddr2 / Q62371 / Discoidin domain-containing receptor 2 / Q16832* / discoidin domain receptor tyrosine kinase 2*ENSMUSG0000002667413
Ddr1 / Q03146 / Epithelial discoidin domain-containing receptor 1 / Q08345* / discoidin domain receptor tyrosine kinase 1*ENSMUSG0000000353413
Ltk / P08923 / Leukocyte tyrosine kinase receptor / P29376* / leukocyte receptor tyrosine kinase*ENSMUSG0000002729713
Ror2 / Q9Z138 / receptor tyrosine kinase-like orphan receptor 2 / Q01974*ENSMUSG0000002146412
Ror1 / Q9Z139 / Inactive tyrosine-protein kinase transmembrane receptor ROR1 / Q01973* / receptor tyrosine kinase like orphan receptor 1*ENSMUSG0000003530512


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013098  Immunoglobulin I-set
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR033592  Inactive tyrosine-protein kinase 7
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001736 establishment of planar polarity IMP
 biological_processGO:0001843 neural tube closure IMP
 biological_processGO:0003281 ventricular septum development IMP
 biological_processGO:0003401 axis elongation IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0031532 actin cytoskeleton reorganization IEA
 biological_processGO:0042060 wound healing IGI
 biological_processGO:0045198 establishment of epithelial cell apical/basal polarity IMP
 biological_processGO:0060026 convergent extension IMP
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0060484 lung-associated mesenchyme development IMP
 biological_processGO:0060976 coronary vasculature development IMP
 biological_processGO:0071300 cellular response to retinoic acid IEA
 biological_processGO:0090103 cochlea morphogenesis IMP
 biological_processGO:0090179 planar cell polarity pathway involved in neural tube closure IGI
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hap1tm2Xjl/Hap1tm2Xjl,Tg(HCRT-cre)1Stak/0
Genetic Background: involves: 129 * C57BL/6 * DBA/1

 MP:0000153 rib bifurcation "forking or division of ribs, may be a result of partial rib fusions" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hap1tm2Xjl/Hap1tm2Xjl,Tg(HCRT-cre)1Stak/0
Genetic Background: involves: 129 * C57BL/6 * DBA/1

 MP:0000154 rib fusion "appearance of one or more ribs as a single structure" [J:62022, J:62023]
Show

Allelic Composition: Hap1tm2Xjl/Hap1tm2Xjl,Tg(HCRT-cre)1Stak/0
Genetic Background: involves: 129 * C57BL/6 * DBA/1

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Hap1tm2Xjl/Hap1tm2Xjl,Tg(HCRT-cre)1Stak/0
Genetic Background: involves: 129 * C57BL/6 * DBA/1

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
Show

Allelic Composition: Hap1tm2Xjl/Hap1tm2Xjl,Tg(HCRT-cre)1Stak/0
Genetic Background: involves: 129 * C57BL/6 * DBA/1

Allelic Composition: Ptk7b2b2445Clo/Ptk7b2b2445Clo
Genetic Background: C57BL/6J-Ptk7b2b2445Clo

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
Show

Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Tg(BEST1-cre)1Taf/0
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: ajl10/a
Genetic Background: Not Specified

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Tg(BEST1-cre)1Taf/0
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0000956 reduced spinal cord size "smaller appearance of the spinal cord" [J:35802]
Show

Allelic Composition: Hap1tm2Xjl/Hap1tm2Xjl,Tg(HCRT-cre)1Stak/0
Genetic Background: involves: 129 * C57BL/6 * DBA/1

 MP:0001095 enlarged trigeminal ganglion "increased size of the group of sensory neuron cell bodies associated with the trigeminal nerve" [J:17131]
Show

Allelic Composition: Hap1tm2Xjl/Hap1tm2Xjl,Tg(HCRT-cre)1Stak/0
Genetic Background: involves: 129 * C57BL/6 * DBA/1

 MP:0001096 abnormal glossopharyngeal ganglion morphology "malformed group of neuron cell bodies associated with the ninth cranial nerve" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Hap1tm2Xjl/Hap1tm2Xjl,Tg(HCRT-cre)1Stak/0
Genetic Background: involves: 129 * C57BL/6 * DBA/1

 MP:0001100 abnormal vagus ganglion morphology "malformed group of sensory neuron cell bodies associated with the vagus nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hap1tm2Xjl/Hap1tm2Xjl,Tg(HCRT-cre)1Stak/0
Genetic Background: involves: 129 * C57BL/6 * DBA/1

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hap1tm2Xjl/Hap1tm2Xjl,Tg(HCRT-cre)1Stak/0
Genetic Background: involves: 129 * C57BL/6 * DBA/1

 MP:0001691 abnormal somite shape "atypical characteristic surface configuration of a segmental mass along the notochord of the developing embryo" [J:37888]
Show

Allelic Composition: ajl10/a
Genetic Background: Not Specified

 MP:0001701 incomplete embryo turning "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]
Show

Allelic Composition: Hap1tm2Xjl/Hap1tm2Xjl,Tg(HCRT-cre)1Stak/0
Genetic Background: involves: 129 * C57BL/6 * DBA/1

 MP:0002639 micrognathia "abnormally reduced size of the jaws, especially of the mandible" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptk7b2b2445Clo/Ptk7b2b2445Clo
Genetic Background: C57BL/6J-Ptk7b2b2445Clo

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: ajl10/a
Genetic Background: Not Specified

 MP:0003047 abnormal thoracic vertebrae morphology "malformation of any or all of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptk7b2b2445Clo/Ptk7b2b2445Clo
Genetic Background: C57BL/6J-Ptk7b2b2445Clo

 MP:0003052 omphalocele "protrusion of abdominal viscera at the base of the umbilical cord, with a covering membranous sac of peritoneum-amnion" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hap1tm2Xjl/Hap1tm2Xjl,Tg(HCRT-cre)1Stak/0
Genetic Background: involves: 129 * C57BL/6 * DBA/1

Allelic Composition: Ptk7b2b2445Clo/Ptk7b2b2445Clo
Genetic Background: C57BL/6J-Ptk7b2b2445Clo

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: ajl10/a
Genetic Background: Not Specified

Allelic Composition: Ptk7chz/Ptk7+,Vangl2Lp/Vangl2+
Genetic Background: involves: A * BALB/cAnN * C3H/HeH

Allelic Composition: Celsr1Crsh/Celsr1+,Ptk7chz/Ptk7+
Genetic Background: involves: 101/H * BALB/c * BALB/cAnN * C3H/HeH

Allelic Composition: Ptk7b2b2445Clo/Ptk7b2b2445Clo
Genetic Background: C57BL/6J-Ptk7b2b2445Clo

 MP:0003400 kinked neural tube "twists or kinks in the embryonic neural tube" [J:66514, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hap1tm2Xjl/Hap1tm2Xjl,Tg(HCRT-cre)1Stak/0
Genetic Background: involves: 129 * C57BL/6 * DBA/1

 MP:0003456 absent tail "completely lacking the appendage at the caudal end of the vertebral column " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptk7b2b2445Clo/Ptk7b2b2445Clo
Genetic Background: C57BL/6J-Ptk7b2b2445Clo

 MP:0003671 abnormal eyelid opening 
Show

Allelic Composition: Hap1tm2Xjl/Hap1tm2Xjl,Tg(HCRT-cre)1Stak/0
Genetic Background: involves: 129 * C57BL/6 * DBA/1

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptk7b2b2445Clo/Ptk7b2b2445Clo
Genetic Background: C57BL/6J-Ptk7b2b2445Clo

 MP:0004393 abnormal cochlear inner hair cell morphology "any structural abnormality in the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there is a single row of flask-shaped inner hair cells tightly surrounded by supporting interphalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a more or less linear (or shallow) U-shaped pattern extend from the cell s surface through the cuticular plate into the endolymphic space inferior to the tectorial membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ajl10/a
Genetic Background: Not Specified

 MP:0004395 increased cochlear inner hair cell number "increased number (or more than the expected single row) of the flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ajl10/a
Genetic Background: Not Specified

 MP:0004401 increased cochlear outer hair cell number "increased number (or more than the expected 3 rows) of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ajl10/a
Genetic Background: Not Specified

 MP:0004491 abnormal orientation of outer hair cell stereociliary bundles "misorientation or rotation of outer hair cell (OHC) stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ajl10/a
Genetic Background: Not Specified

Allelic Composition: Ptk7chz/Ptk7chz
Genetic Background: involves: BALB/cAnN * C3H/HeH

 MP:0004492 abnormal orientation of inner hair cell stereociliary bundles "misorientation or rotation of inner hair cell (IHC) stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ajl10/a
Genetic Background: Not Specified

 MP:0008784 craniorachischisis "congenital fissure of the skull and vertebral column" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ajl10/a
Genetic Background: Not Specified

Allelic Composition: Ptk7chz/Ptk7chz
Genetic Background: involves: BALB/cAnN * C3H/HeH

Allelic Composition: Ptk7chz/Ptk7+,Vangl2Lp/Vangl2+
Genetic Background: involves: A * BALB/cAnN * C3H/HeH

 MP:0009743 preaxial polydactyly "duplication of all or part of the first ray on one or more of the autopods" [PMID:19125433]
Show

Allelic Composition: Ptk7chz/Ptk7chz
Genetic Background: involves: BALB/cAnN * C3H/HeH

Allelic Composition: Ptk7b2b2445Clo/Ptk7b2b2445Clo
Genetic Background: C57BL/6J-Ptk7b2b2445Clo

 MP:0009744 postaxial polydactyly "duplication of all or part of any of the rays except the first ray on one or more of the autopods" [PMID:19125433]
Show

Allelic Composition: Ptk7chz/Ptk7chz
Genetic Background: involves: BALB/cAnN * C3H/HeH

 MP:0009845 abnormal neural crest cell morphology "any structural anomaly of the transient and migratory group of cells that emerge from the dorsal region of the neural tube and disperse to many peripheral locations to form various tissues of the adult" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptk7chz/Ptk7chz
Genetic Background: involves: BALB/cAnN * C3H/HeH

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
Show

Allelic Composition: Ptk7chz/Ptk7chz
Genetic Background: involves: BALB/cAnN * C3H/HeH

Allelic Composition: Ptk7b2b2445Clo/Ptk7b2b2445Clo
Genetic Background: C57BL/6J-Ptk7b2b2445Clo

 MP:0010557 dilated pulmonary artery "the luminal space of the pulmonary artery is increased in volume or area, usually with an increase of contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptk7chz/Ptk7chz
Genetic Background: involves: BALB/cAnN * C3H/HeH

 MP:0010975 abnormal lung lobe morphology "any structural anomaly of any of the anatomically and functionally distinct subunits (lobes) comprising the left or right lung, where each lobe receives air from its own secondary bronchus and is separated from it neighbors by one or more fissures (walls of connective tissue)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptk7chz/Ptk7chz
Genetic Background: involves: BALB/cAnN * C3H/HeH

 MP:0010976 small lung lobe "reduced size of any of the anatomically and functionally distinct subunits (lobes) comprising the left or right lung, where each lobe receives air from its own secondary bronchus and is separated from it neighbors by one or more fissures (walls of connective tissue)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptk7chz/Ptk7chz
Genetic Background: involves: BALB/cAnN * C3H/HeH

 MP:0011062 abnormal outer hair cell kinocilium morphology "any structural anomaly of the nonmotile primary cilium that is found at the apical surface of outer hair cells" [GO:0060091]
Show

Allelic Composition: ajl10/a
Genetic Background: Not Specified

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: ajl10/a
Genetic Background: Not Specified

 MP:0011143 thick lung-associated mesenchyme "increased thickness of the mesenchymal cell layer due to delay or failure of the mesenchymal compartment to thin down during the late stages of embryonic lung development" [MGI:anna]
Show

Allelic Composition: Ptk7chz/Ptk7chz
Genetic Background: involves: BALB/cAnN * C3H/HeH

 MP:0012675 enlarged floor plate "increased size of the specialized glial structure (non-neuronal cells) situated at the ventral midline of the embryonic neural tube; this structure spans the anteroposterior axis from the midbrain to the tail regions, separating the left and right basal plates of the developing neural tube, and serves as an organizer to ventralize tissues in the embryo as well as to guide neuronal positioning and differentiation along the dorsoventral axis of the neural tube" [MGI:anna]
Show

Allelic Composition: ajl10/a
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr