ENSMUSG00000055471


Mus musculus

Features
Gene ID: ENSMUSG00000055471
  
Biological name :Alk
  
Synonyms : Alk / ALK tyrosine kinase receptor / P97793
  
Possible biological names infered from orthology : ALK receptor tyrosine kinase / Q9UM73
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: E1.3
Gene start: 71869442
Gene end: 72603709
  
Corresponding Affymetrix probe sets: 10452734 (MoGene1.0st)   1449987_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000083840
NCBI entrez gene - 11682     See in Manteia.
MGI - MGI:103305
RefSeq - NM_007439
RefSeq Peptide - NP_031465
swissprot - P97793
Ensembl - ENSMUSG00000055471
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 alkENSDARG00000095833Danio rerio
 ENSGALG00000009034Gallus gallus
 ALKENSG00000171094Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ltk / P08923 / Leukocyte tyrosine kinase receptor / P29376* / leukocyte receptor tyrosine kinase*ENSMUSG0000002729728
Ros1 / Q78DX7 / Proto-onco tyrosine-protein kinase ROS / P08922* / ROS proto-oncogene 1, receptor tyrosine kinase*ENSMUSG0000001989316
Igf1r / insulin like growth factor 1 receptor / P08069*ENSMUSG0000000553315
Insrr / Q9WTL4 / Insulin receptor-related protein Insulin receptor-related protein alpha chain Insulin receptor-related protein beta chain / P14616* / insulin receptor related receptor*ENSMUSG0000000564015
Insr / P15208 / Insulin receptor Insulin receptor subunit alpha Insulin receptor subunit beta / P06213* / insulin receptor*ENSMUSG0000000553415
Ntrk2 / P15209 / BDNF/NT-3 growth factors receptor / Q16620* / neurotrophic receptor tyrosine kinase 2*ENSMUSG0000005525411
Ror1 / Q9Z139 / Inactive tyrosine-protein kinase transmembrane receptor ROR1 / Q01973* / receptor tyrosine kinase like orphan receptor 1*ENSMUSG0000003530511
Ntrk3 / Q6VNS1 / NT-3 growth factor receptor / Q16288* / neurotrophic receptor tyrosine kinase 3*ENSMUSG0000005914611
Ntrk1 / Q3UFB7 / High affinity nerve growth factor receptor / P04629* / neurotrophic receptor tyrosine kinase 1*ENSMUSG0000002807211
Ddr1 / Q03146 / Epithelial discoidin domain-containing receptor 1 / Q08345* / discoidin domain receptor tyrosine kinase 1*ENSMUSG0000000353410
Ddr2 / Q62371 / Discoidin domain-containing receptor 2 / Q16832* / discoidin domain receptor tyrosine kinase 2*ENSMUSG0000002667410
Musk / Q61006 / Muscle, skeletal receptor tyrosine-protein kinase / O15146* / muscle associated receptor tyrosine kinase*ENSMUSG0000005728010
Ror2 / Q9Z138 / receptor tyrosine kinase-like orphan receptor 2 / Q01974*ENSMUSG0000002146410
Ptk7 / Q8BKG3 / Inactive tyrosine-protein kinase 7 / Q13308* / protein tyrosine kinase 7 (inactive)*ENSMUSG000000239729


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000998  MAM domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR002011  Tyrosine-protein kinase, receptor class II, conserved site
 IPR002172  Low-density lipoprotein (LDL) receptor class A repeat
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR026830  ALK tyrosine kinase receptor
 IPR036055  LDL receptor-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007420 brain development IMP
 biological_processGO:0016310 phosphorylation ISO
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0021766 hippocampus development IMP
 biological_processGO:0030534 adult behavior IMP
 biological_processGO:0036269 swimming behavior IMP
 biological_processGO:0042127 regulation of cell proliferation IMP
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0048666 neuron development IEA
 biological_processGO:0060159 regulation of dopamine receptor signaling pathway IMP
 biological_processGO:0090648 response to environmental enrichment IMP
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon ISO
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0044297 cell body ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity ISO
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity ISS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000422 delayed hair appearance "late onset of the first appearance of the fur" [J:17792]
Show

Allelic Composition: Alktm2.1Ics/Alktm2.1Ics
Genetic Background: B6N.129S2(Cg)-Alktm2.1Ics

 MP:0000837 abnormal hypothalamus morphology "any malformation or absence of the ventral part of the diencephalon extending from the region of the optic chiasm to the caudal border of the mammillary bodies and forming the inferior and lateral walls of the third ventricle; this region regulates the autonomic nervous system via hormone production and release" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Sox17tm1.1Nat/Sox17tm1.1Nat
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0001008 abnormal sympathetic ganglia morphology "malformed or absent groups of neuronal cell bodies of the autonomic nervous system" [J:18048]
Show

Allelic Composition: Gdap1tm1.1Ics/Gdap1tm1.1Ics
Genetic Background: Not Specified

Allelic Composition: Alktm2.1Ics/Alktm2.1Ics
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001011 abnormal superior cervical ganglion morphology "malformation or absence of the group of neurons that is the largest of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Alktm2.1Ics/Alk+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Alktm2.1Ics/Alktm2.1Ics
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001013 enlarged superior cervical ganglion "increased size of the group of neurons that is the largest of the ganglia of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck" [J:17131]
Show

Allelic Composition: Gdap1tm1.1Ics/Gdap1tm1.1Ics
Genetic Background: Not Specified

Allelic Composition: Alktm2.1Ics/Alk+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Alktm2.1Ics/Alktm2.1Ics
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001017 abnormal stellate ganglion morphology "malformation or absence of the group of neurons formed by the fusion of the inferior cervical and first thoracic ganglia" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gdap1tm1.1Ics/Gdap1tm1.1Ics
Genetic Background: Not Specified

Allelic Composition: Alktm2.1Ics/Alk+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Alktm2.1Ics/Alktm2.1Ics
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Sox17tm1.1Nat/Sox17tm1.1Nat
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Sox17tm1.1Nat/Sox17tm1.1Nat
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Alktm2.1Ics/Alktm2.1Ics
Genetic Background: B6N.129S2(Cg)-Alktm2.1Ics

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Alktm2.1Ics/?,Tg(Th-MYCN)41Waw/0
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6J

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
Show

Allelic Composition: Alktm2.1Ics/?,Tg(Th-MYCN)41Waw/0
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6J

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Alktm2.1Ics/?,Tg(Th-MYCN)41Waw/0
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6J

 MP:0001752 abnormal hypothalamus secretion "altered ability of the hypothalamus to release its contents" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sox17tm1.1Nat/Sox17tm1.1Nat
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0001938 delayed sexual maturation "immaturity of the sexual organs at a given age" [J:61190]
Show

Allelic Composition: Sox17tm1.1Nat/Sox17tm1.1Nat
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0001957 apnea "absence of breathing; sometimes episodic" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17384]
Show

Allelic Composition: Alktm2.1Ics/Alktm2.1Ics
Genetic Background: B6N.129S2(Cg)-Alktm2.1Ics

 MP:0002039 neuroblastoma "malignant neoplasm characterized by immature nerve cells of embryonic type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58877]
Show

Allelic Composition: Alktm2.1Ics/Alktm2.1Ics
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Alktm2.1Ics/?,Tg(Th-MYCN)41Waw/0
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6J

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Alktm2.1Ics/?,Tg(Th-MYCN)41Waw/0
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6J

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox17tm1.1Nat/Sox17tm1.1Nat
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0002673 abnormal sperm count "increased or decreased numbers of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox17tm1.1Nat/Sox17tm1.1Nat
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Alktm2.1Ics/?,Tg(Th-MYCN)41Waw/0
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6J

 MP:0002780 decreased circulating testosterone level "less than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sox17tm1.1Nat/Sox17tm1.1Nat
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Alktm2.1Ics/?,Tg(Th-MYCN)41Waw/0
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6J

 MP:0003019 increased circulating chloride level "elevated concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Alktm2.1Ics/?,Tg(Th-MYCN)41Waw/0
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6J

 MP:0003545 increased alcohol consumption "greater than normal consumption of alcohol" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Chd1tm1c(KOMP)Rsan/Chd1tm1c(KOMP)Rsan,Edil3Tg(Sox2-cre)1Amc/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA

 MP:0004214 abnormal long bone diaphysis morphology "any structural anomaly of the main or mid section (shaft) of a long bone" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Alktm2.1Ics/Alktm2.1Ics
Genetic Background: B6N.129S2(Cg)-Alktm2.1Ics

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sox17tm1.1Nat/Sox17tm1.1Nat
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Alktm2.1Ics/?,Tg(Th-MYCN)41Waw/0
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6J

Allelic Composition: Alktm2.1Ics/Alktm2.1Ics
Genetic Background: B6N.129S2(Cg)-Alktm2.1Ics

 MP:0005250 Sertoli cell hypoplasia "decreased number of cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:70212]
Show

Allelic Composition: Sox17tm1.1Nat/Sox17tm1.1Nat
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0006362 abnormal male germ cell morphology "any structural anomaly of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sox17tm1.1Nat/Sox17tm1.1Nat
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sox17tm1.1Nat/Sox17tm1.1Nat
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0008940 delayed balanopreputial separation "the separation of the prepuce from the glans penis (balanus), a result of the cornification of the balano-preputial epithelium, occurring at a later than expected age; balanopreputial separation is used as an index for the onset of male puberty and is androgen-sensitive in the rat" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sox17tm1.1Nat/Sox17tm1.1Nat
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0008975 delayed male fertility "ability of a male organism to produce live offspring occurring at a later than expected age" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sox17tm1.1Nat/Sox17tm1.1Nat
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0009751 enhanced behavioral response to alcohol "increased sensitivity to alcohol resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Chd1tm1c(KOMP)Rsan/Chd1tm1c(KOMP)Rsan,Edil3Tg(Sox2-cre)1Amc/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA

 MP:0010052 increased grip strength "greater ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Alktm2.1Ics/?,Tg(Th-MYCN)41Waw/0
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6J

 MP:0010232 delayed skin pigmentation appearance "lag in the time that normal coloration of the skin color occurs in relation to control animals" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Alktm2.1Ics/Alktm2.1Ics
Genetic Background: B6N.129S2(Cg)-Alktm2.1Ics

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Alktm2.1Ics/Alktm2.1Ics
Genetic Background: B6N.129S2(Cg)-Alktm2.1Ics

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Alktm2.1Ics/Alktm2.1Ics
Genetic Background: B6N.129S2(Cg)-Alktm2.1Ics

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Alktm2.1Ics/?,Tg(Th-MYCN)41Waw/0
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6J

Allelic Composition: Alktm2.1Ics/Alktm2.1Ics
Genetic Background: B6N.129S2(Cg)-Alktm2.1Ics

 MP:0013601 increased testis apoptosis "increase in the number of cells of the male reproductive glands undergoing programmed cell death" [MGI:Anna]
Show

Allelic Composition: Sox17tm1.1Nat/Sox17tm1.1Nat
Genetic Background: involves: 129 * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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