ENSMUSG00000027297


Mus musculus

Features
Gene ID: ENSMUSG00000027297
  
Biological name :Ltk
  
Synonyms : Leukocyte tyrosine kinase receptor / Ltk / P08923
  
Possible biological names infered from orthology : leukocyte receptor tyrosine kinase / P29376
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: E5
Gene start: 119751320
Gene end: 119760431
  
Corresponding Affymetrix probe sets: 10486262 (MoGene1.0st)   1460300_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028759
Ensembl peptide - ENSMUSP00000080774
Ensembl peptide - ENSMUSP00000123020
Ensembl peptide - ENSMUSP00000138201
NCBI entrez gene - 17005     See in Manteia.
MGI - MGI:96840
RefSeq - NM_203345
RefSeq - NM_008523
RefSeq - NM_206941
RefSeq - NM_206942
RefSeq Peptide - NP_996824
RefSeq Peptide - NP_032549
RefSeq Peptide - NP_976220
RefSeq Peptide - NP_996825
swissprot - P08923
swissprot - F6V2R5
swissprot - Q0VGZ5
Ensembl - ENSMUSG00000027297
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ltkENSDARG00000042861Danio rerio
 LTKENSGALG00000008615Gallus gallus
 LTKENSG00000062524Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Alk / P97793 / ALK tyrosine kinase receptor / Q9UM73* / ALK receptor tyrosine kinase*ENSMUSG0000005547151
Ros1 / Q78DX7 / Proto-onco tyrosine-protein kinase ROS / P08922* / ROS proto-oncogene 1, receptor tyrosine kinase*ENSMUSG0000001989323
Insrr / Q9WTL4 / Insulin receptor-related protein Insulin receptor-related protein alpha chain Insulin receptor-related protein beta chain / P14616* / insulin receptor related receptor*ENSMUSG0000000564022
Igf1r / insulin like growth factor 1 receptor / P08069*ENSMUSG0000000553322
Insr / P15208 / Insulin receptor Insulin receptor subunit alpha Insulin receptor subunit beta / P06213* / insulin receptor*ENSMUSG0000000553421
Ror1 / Q9Z139 / Inactive tyrosine-protein kinase transmembrane receptor ROR1 / Q01973* / receptor tyrosine kinase like orphan receptor 1*ENSMUSG0000003530517
Musk / Q61006 / Muscle, skeletal receptor tyrosine-protein kinase / O15146* / muscle associated receptor tyrosine kinase*ENSMUSG0000005728016
Ntrk2 / P15209 / BDNF/NT-3 growth factors receptor / Q16620* / neurotrophic receptor tyrosine kinase 2*ENSMUSG0000005525416
Ntrk1 / Q3UFB7 / High affinity nerve growth factor receptor / P04629* / neurotrophic receptor tyrosine kinase 1*ENSMUSG0000002807216
Ptk7 / Q8BKG3 / Inactive tyrosine-protein kinase 7 / Q13308* / protein tyrosine kinase 7 (inactive)*ENSMUSG0000002397216
Ror2 / Q9Z138 / receptor tyrosine kinase-like orphan receptor 2 / Q01974*ENSMUSG0000002146416
Ntrk3 / Q6VNS1 / NT-3 growth factor receptor / Q16288* / neurotrophic receptor tyrosine kinase 3*ENSMUSG0000005914616
Ddr1 / Q03146 / Epithelial discoidin domain-containing receptor 1 / Q08345* / discoidin domain receptor tyrosine kinase 1*ENSMUSG0000000353415
Ddr2 / Q62371 / Discoidin domain-containing receptor 2 / Q16832* / discoidin domain receptor tyrosine kinase 2*ENSMUSG0000002667414


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR002011  Tyrosine-protein kinase, receptor class II, conserved site
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation ISS
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0008283 cell proliferation ISS
 biological_processGO:0010666 positive regulation of cardiac muscle cell apoptotic process ISO
 biological_processGO:0010976 positive regulation of neuron projection development ISO
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling ISO
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0043066 negative regulation of apoptotic process ISS
 biological_processGO:0071300 cellular response to retinoic acid ISO
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0016021 integral component of membrane IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity ISS
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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