ENSMUSG00000055254


Mus musculus

Features
Gene ID: ENSMUSG00000055254
  
Biological name :Ntrk2
  
Synonyms : BDNF/NT-3 growth factors receptor / Ntrk2 / P15209
  
Possible biological names infered from orthology : neurotrophic receptor tyrosine kinase 2 / Q16620
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: B1
Gene start: 58806569
Gene end: 59133970
  
Corresponding Affymetrix probe sets: 10405633 (MoGene1.0st)   1420837_at (Mouse Genome 430 2.0 Array)   1420838_at (Mouse Genome 430 2.0 Array)   1435196_at (Mouse Genome 430 2.0 Array)   1435305_at (Mouse Genome 430 2.0 Array)   1437560_at (Mouse Genome 430 2.0 Array)   1444121_at (Mouse Genome 430 2.0 Array)   1446712_at (Mouse Genome 430 2.0 Array)   1458622_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000153270
Ensembl peptide - ENSMUSP00000153152
Ensembl peptide - ENSMUSP00000153333
Ensembl peptide - ENSMUSP00000153553
Ensembl peptide - ENSMUSP00000153337
Ensembl peptide - ENSMUSP00000078757
Ensembl peptide - ENSMUSP00000105464
Ensembl peptide - ENSMUSP00000152907
NCBI entrez gene - 18212     See in Manteia.
MGI - MGI:97384
RefSeq - XM_017315420
RefSeq - NM_001025074
RefSeq - NM_001282961
RefSeq - NM_008745
RefSeq - XM_006517149
RefSeq - XM_006517150
RefSeq - XM_006517151
RefSeq - XM_006517152
RefSeq - XM_017315419
RefSeq Peptide - NP_032771
RefSeq Peptide - NP_001020245
RefSeq Peptide - NP_001269890
swissprot - A0A286YCV8
swissprot - P15209
swissprot - Q3UHE3
swissprot - A0A286YCB7
swissprot - A0A286YDA3
swissprot - A0A286YDA0
Ensembl - ENSMUSG00000055254
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ntrk2aENSDARG00000059897Danio rerio
 ntrk2bENSDARG00000098511Danio rerio
 NTRK2ENSGALG00000012594Gallus gallus
 NTRK2ENSG00000148053Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ntrk3 / Q6VNS1 / NT-3 growth factor receptor / Q16288* / neurotrophic receptor tyrosine kinase 3*ENSMUSG0000005914654
Ntrk1 / Q3UFB7 / High affinity nerve growth factor receptor / P04629* / neurotrophic receptor tyrosine kinase 1*ENSMUSG0000002807247
Musk / Q61006 / Muscle, skeletal receptor tyrosine-protein kinase / O15146* / muscle associated receptor tyrosine kinase*ENSMUSG0000005728028
Ddr2 / Q62371 / Discoidin domain-containing receptor 2 / Q16832* / discoidin domain receptor tyrosine kinase 2*ENSMUSG0000002667426
Insr / P15208 / Insulin receptor Insulin receptor subunit alpha Insulin receptor subunit beta / P06213* / insulin receptor*ENSMUSG0000000553425
Ros1 / Q78DX7 / Proto-onco tyrosine-protein kinase ROS / P08922* / ROS proto-oncogene 1, receptor tyrosine kinase*ENSMUSG0000001989324
Igf1r / insulin like growth factor 1 receptor / P08069*ENSMUSG0000000553324
Insrr / Q9WTL4 / Insulin receptor-related protein Insulin receptor-related protein alpha chain Insulin receptor-related protein beta chain / P14616* / insulin receptor related receptor*ENSMUSG0000000564024
Ddr1 / Q03146 / Epithelial discoidin domain-containing receptor 1 / Q08345* / discoidin domain receptor tyrosine kinase 1*ENSMUSG0000000353424
Alk / P97793 / ALK tyrosine kinase receptor / Q9UM73* / ALK receptor tyrosine kinase*ENSMUSG0000005547122
Ror1 / Q9Z139 / Inactive tyrosine-protein kinase transmembrane receptor ROR1 / Q01973* / receptor tyrosine kinase like orphan receptor 1*ENSMUSG0000003530522
Ror2 / Q9Z138 / receptor tyrosine kinase-like orphan receptor 2 / Q01974*ENSMUSG0000002146422
Ptk7 / Q8BKG3 / Inactive tyrosine-protein kinase 7 / Q13308* / protein tyrosine kinase 7 (inactive)*ENSMUSG0000002397219
Ltk / P08923 / Leukocyte tyrosine kinase receptor / P29376* / leukocyte receptor tyrosine kinase*ENSMUSG0000002729718


Protein motifs (from Interpro)
Interpro ID Name
 IPR000372  Leucine-rich repeat N-terminal domain
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001611  Leucine-rich repeat
 IPR002011  Tyrosine-protein kinase, receptor class II, conserved site
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR017441  Protein kinase, ATP binding site
 IPR020455  Tyrosine-protein kinase, neurotrophic receptor, type 2
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR020777  Tyrosine-protein kinase, neurotrophic receptor
 IPR031635  Tyrosine-protein kinase receptor NTRK, C2-Ig-like domain
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001570 vasculogenesis IMP
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007528 neuromuscular junction development IMP
 biological_processGO:0007612 learning IMP
 biological_processGO:0007623 circadian rhythm IEP
 biological_processGO:0007631 feeding behavior IMP
 biological_processGO:0008284 positive regulation of cell proliferation ISS
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010976 positive regulation of neuron projection development IDA
 biological_processGO:0014047 glutamate secretion IPI
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling ISS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0019222 regulation of metabolic process IMP
 biological_processGO:0021954 central nervous system neuron development IMP
 biological_processGO:0021987 cerebral cortex development IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030182 neuron differentiation IMP
 biological_processGO:0031547 brain-derived neurotrophic factor receptor signaling pathway IDA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IMP
 biological_processGO:0038179 neurotrophin signaling pathway IEA
 biological_processGO:0042490 mechanoreceptor differentiation IMP
 biological_processGO:0043087 regulation of GTPase activity IDA
 biological_processGO:0043410 positive regulation of MAPK cascade ISS
 biological_processGO:0043524 negative regulation of neuron apoptotic process ISS
 biological_processGO:0046548 retinal rod cell development IMP
 biological_processGO:0046777 protein autophosphorylation ISS
 biological_processGO:0048709 oligodendrocyte differentiation IMP
 biological_processGO:0048935 peripheral nervous system neuron development IMP
 biological_processGO:0050772 positive regulation of axonogenesis ISS
 biological_processGO:0051896 regulation of protein kinase B signaling IMP
 biological_processGO:0051965 positive regulation of synapse assembly IDA
 biological_processGO:0060041 retina development in camera-type eye IMP
 biological_processGO:0060291 long-term synaptic potentiation IMP
 biological_processGO:0071230 cellular response to amino acid stimulus IDA
 biological_processGO:0099551 trans-synaptic signaling by neuropeptide, modulating synaptic transmission IMP
 biological_processGO:2000324 positive regulation of glucocorticoid receptor signaling pathway ISO
 biological_processGO:2000811 negative regulation of anoikis IDA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0043195 terminal bouton IDA
 cellular_componentGO:0043235 receptor complex ISO
 cellular_componentGO:0045211 postsynaptic membrane IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005030 neurotrophin receptor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity ISS
 molecular_functionGO:0043121 neurotrophin binding ISO
 molecular_functionGO:0048403 brain-derived neurotrophic factor binding IDA
 molecular_functionGO:0060175 brain-derived neurotrophic factor-activated receptor activity IDA


Pathways (from Reactome)
Pathway description
Activated NTRK2 signals through PLCG1
Activated NTRK2 signals through FRS2 and FRS3


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000013 abnormal fat distribution "alterations in the normal placement and amount of body fat" [J:57315]
Show

Allelic Composition: Errfi1tm3.1Gvw/Errfi1tm3.1Gvw,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * BALB/cJ

 MP:0000034 abnormal vestibule morphology "malformed cavity between the semicircular canals and the cochlea of the inner ear" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]
Show

Allelic Composition: Ntrk1tm1Par/Ntrk1tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Ntrk2tm1Bbd/Ntrk2tm1Kln
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ntrk2tm2Lfp/Ntrk2tm2Lfp,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0000480 increased number of ribs "greater than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Nr6a1tm1b(EUCOMM)Wtsi/Nr6a1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nr6a1tm1b(EUCOMM)Wtsi/Bay

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Ntrk2tm2Kln/Ntrk2tm2Kln,Tg(Cck-cre,-lacZ)1Mini/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Mcl1tm1Dmta/Mcl1+,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Mcl1tm1Dmta Gt(ROSA)26Sortm9(cre/ESR1)Arte

Allelic Composition: Ntrk2tm2Kln/Ntrk2tm2Kln,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0000805 abnormal visual cortex morphology "malformation or absence of the area of the occipital cortex concerned with vision" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Apoetm1(APOE)Sfu/Apoetm1(APOE)Sfu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

Allelic Composition: Ntrk2tm2Kln/Ntrk2tm2Kln,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0000818 abnormal amygdala morphology "any malformation or absence of the almond-shaped body of basal nuclei anterior to the inferior horn of the lateral ventricle of the brain, within the temporal lobe; this area is involved in aggression and fear responses" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fras1tm1Chpk/Fras1tm1Chpk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0000854 abnormal cerebellum development "malformed or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ntrk2tm1Lfp/Ntrk2tm1Lfp
Genetic Background: involves: 129 * C57

 MP:0000859 abnormal somatosensory cortex morphology "any malformation or absence of the area of the parietal lobe that lies posterior to the central sulcus and is concerned with receiving and processing general sensations from the body surface" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Apoetm1(APOE)Sfu/Apoetm1(APOE)Sfu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

Allelic Composition: Ntrk2tm2Kln/Ntrk2tm2Kln,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0000910 small facial motor nucleus "reduced size of the group of motor neurons residing in the pons that innervate the muscles of facial expression" [Principles of Neural Science:ISBN 0-8385-8034-3, J:56847]
Show

Allelic Composition: Ntrk1tm1Par/Ntrk1tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd247tm1Lov/Cd247tm1Lov,Fcer1gtm1Rav/Fcer1gtm1Rav
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ntrk2tm2Kln/Ntrk2tm2Kln,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Ntrk1tm1Par/Ntrk1tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000959 abnormal somatic sensory system morphology 
Show

Allelic Composition: Ntrk1tm1Par/Ntrk1tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000964 small dorsal root ganglia "reduced size of the dorsal root ganglia" [J:17123]
Show

Allelic Composition: Ntrk1tm1Par/Ntrk1tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000966 reduced sensory neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln,Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Bdnftm1Jae/Bdnftm2(Ntf5)Jae,Ntrk2tm1Kln/Ntrk2tm1Kln
Genetic Background: involves: 129S4/SvJae

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
Show

Allelic Composition: Ntrk1tm1Par/Ntrk1tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ntrk2tm1Lfp/Ntrk2tm1Lfp
Genetic Background: involves: 129 * C57

Allelic Composition: Ntrk2tm1Bbd/Ntrk2tm1Bbd
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ntrk2tm1Bbd/Ntrk2tm1Kln
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

Allelic Composition: Ntrk2tm4.1Ddg/Ntrk2tm4.1Ddg,Aviltm2(cre)Fawa/Avil+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ntrk2tm1.1Tes/Ntrk2tm1.1Tes
Genetic Background: involves: 129S1/Sv

Allelic Composition: Ntrk2tm1Ddg/Ntrk2tm1Ddg
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Ntrk2tm2.1Ddg/Ntrk2tm2.1Ddg
Genetic Background: involves: 129P2/OlaHsd

 MP:0000980 absent hair-down neurons "absence of the subcutaneous mechanoreceptors that innervate vellus hairs" [J:49472]
Show

Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001021 small L4 ganglion "reduced size of L4 ganglion" [J:17792]
Show

Allelic Composition: Ntrk2tm1Bbd/Ntrk2tm1Bbd
Genetic Background: involves: 129S2/SvPas

 MP:0001072 abnormal vestibulocochlear nerve morphology "malformed sensory nerve innervating the receptor cells of the membranous labyrinth" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837]
Show

Allelic Composition: Ntrk1tm1Par/Ntrk1tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001083 small geniculate ganglion "reduced size of the geniculate ganglion or decreased size of sensory neuron cell bodies associated with the facial nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ntrk2tm1Lfp/Ntrk2tm1Lfp
Genetic Background: involves: 129 * C57

Allelic Composition: Ntrk2tm1Bbd/Ntrk2tm1Bbd
Genetic Background: involves: 129S2/SvPas

 MP:0001085 small petrosal ganglion "reduced size of the petrosal ganglion" [J:25565]
Show

Allelic Composition: Ntrk2tm1Lfp/Ntrk2tm1Lfp
Genetic Background: involves: 129 * C57

Allelic Composition: Ntrk2tm1Bbd/Ntrk2tm1Bbd
Genetic Background: involves: 129S2/SvPas

 MP:0001088 small nodose ganglion "reduced size of the nodose ganglion" [J:25565, J:17123]
Show

Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ntrk2tm1Lfp/Ntrk2tm1Lfp
Genetic Background: involves: 129 * C57

Allelic Composition: Ntrk2tm1Bbd/Ntrk2tm1Bbd
Genetic Background: involves: 129S2/SvPas

 MP:0001093 small trigeminal ganglion "reduced size of the trigeminal ganglion" [J:25565, J:17123]
Show

Allelic Composition: Ntrk1tm1Par/Ntrk1tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Ntrk2tm1Lfp/Ntrk2tm1Lfp
Genetic Background: involves: 129 * C57

Allelic Composition: Ntrk2tm1Bbd/Ntrk2tm1Bbd
Genetic Background: involves: 129S2/SvPas

 MP:0001129 impaired ovarian folliculogenesis "a block in the formation of the spherical ovum in the ovary" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Mxi1tm1Rdp/Mxi1tm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ntrk2tm2Lfp/Ntrk2tm2Lfp,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Ntrk2tm1.1Tes/Ntrk2+
Genetic Background: B6.129S1-Ntrk2tm1.1Tes

Allelic Composition: Ntrk2tm2Kln/Ntrk2tm2Kln,Tg(Cck-cre,-lacZ)1Mini/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Mxi1tm1Rdp/Mxi1tm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Ntrk2tm2Lfp/Ntrk2tm2Lfp,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Ntrk2tm1Rohr/Ntrk2+
Genetic Background: Not Specified

Allelic Composition: Ntrk2tm2Lfp/Ntrk2tm2Lfp,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0001330 abnormal optic nerve morphology "malformation, misprojection or atrophy in the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Mxi1tm1Rdp/Mxi1tm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0001340 abnormal eyelid morphology "malformation of the skin folds covering the front of the eyeball" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ntrk2tm1Rohr/Ntrk2+
Genetic Background: Not Specified

 MP:0001354 increased aggression towards males "when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward male mice" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Webster s II New College Dictionary:ISBN 0-395-70869-9]
Show

Allelic Composition: Bdnftm1Par/Bdnf+,Ntrk2tm1.1Tes/Ntrk2tm1.1Tes
Genetic Background: B6.129S1-Bdnftm1Par Ntrk2tm1.1Tes

Allelic Composition: Bdnftm1Par/Bdnf+,Ntrk2tm1.1Tes/Ntrk2+
Genetic Background: B6.129S1-Bdnftm1Par Ntrk2tm1.1Tes

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Ntrk1tm1Par/Ntrk1tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Bdnftm2(Ntf5)Jae/Bdnftm2(Ntf5)Jae,Ntrk2tm1Kln/Ntrk2tm1Kln
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Bdnftm1Jae/Bdnftm2(Ntf5)Jae,Ntrk2tm1Kln/Ntrk2tm1Kln
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Ntrk2tm2Kln/Ntrk2tm2Kln,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Ntrk2tm2Kln/Ntrk2tm2Kln,Tg(Penk-cre,-lacZ)1Mini/0
Genetic Background: involves: 129S2/SvPas

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Ntrk2tm2Kln/Ntrk2tm2Kln,Slc1a3tm1(cre/ERT2)Mgoe/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0001410 head bobbing "compulsive up and down movement of the head" [J:17123]
Show

Allelic Composition: Bdnftm1Jae/Bdnftm2(Ntf5)Jae,Ntrk2tm1Kln/Ntrk2tm1Kln
Genetic Background: involves: 129S4/SvJae

 MP:0001411 spinning "compulsive rolling of the body" [J:17123]
Show

Allelic Composition: Bdnftm1Jae/Bdnftm2(Ntf5)Jae,Ntrk2tm1Kln/Ntrk2tm1Kln
Genetic Background: involves: 129S4/SvJae

 MP:0001435 no suckling reflex "inability to orient and open/close mouth in sucking pattern in response to external light touching or stroking of the chin" [J:56847]
Show

Allelic Composition: Ntrk1tm1Par/Ntrk1tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001437 no swallowing reflex "inability to pull food through the esophagus to the stomach in response to feeding" [J:56847]
Show

Allelic Composition: Ntrk1tm1Par/Ntrk1tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001462 abnormal avoidance learning behavior "defects in the ability to associate a previously neutral stimulus with an unpleasant or punishing stimuli so that the animal learns to avoid the previously neutral stimulus" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Cd247tm1Lov/Cd247tm1Lov,Fcer1gtm1Rav/Fcer1gtm1Rav
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Cd247tm1Lov/Cd247tm1Lov,Fcer1gtm1Rav/Fcer1gtm1Rav
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0001469 abnormal contextual conditioning "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Cd247tm1Lov/Cd247tm1Lov,Fcer1gtm1Rav/Fcer1gtm1Rav
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Cd247tm1Lov/Cd247tm1Lov,Fcer1gtm1Rav/Fcer1gtm1Rav
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Ntrk2tm2Kln/Ntrk2tm2Kln,Slc1a3tm1(cre/ERT2)Mgoe/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * SJL

Allelic Composition: Ntrk2tm2.1Tes/Ntrk2tm2.1Tes
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001490 abnormal vibrissae reflex "animals do not change position in response to stimulation of the whiskers" [J:17194]
Show

Allelic Composition: Ntrk1tm1Par/Ntrk1tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001500 reduced kindling behavior "fewer epileptic episodes induced by daily sub threshold electrical brain stimulation" [J:45446]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tgfbr2tm1Roes/Tgfbr2tm1Roes
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Ntrk2tm1Jom/Ntrk2+,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129/Sv * C57BL/6 * ICR

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
Show

Allelic Composition: Ntrk2tm1Rohr/Ntrk2+
Genetic Background: Not Specified

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ntrk2tm2Kln/Ntrk2tm2Kln,Tg(Cck-cre,-lacZ)1Mini/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mcl1tm1Dmta/Mcl1+,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Mcl1tm1Dmta Gt(ROSA)26Sortm9(cre/ESR1)Arte

Allelic Composition: Ntrk2tm2Kln/Ntrk2tm2Kln,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Ntrk2tm2Lfp/Ntrk2tm2Lfp,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0001748 increased circulating adrenocorticotropin level "elevated concentration in the blood of the pituitary hormone that stimulates the secretion of adrenal cortical steroids and induces growth of the adrenal cortex " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
Show

Allelic Composition: Ntrk2tm1Mini/Ntrk2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001900 impaired synaptic plasticity "decreased or inability of the nervous system to change its reactivity as a result of successive activations " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Foxn1nu/Foxn1nu
Genetic Background: involves: BALB/c

Allelic Composition: Ntrk2tm2Kln/Ntrk2tm2Kln,Tg(Camk2a-cre)159Kln/?
Genetic Background: involves: 129S2/SvPas * CBA/J

 MP:0001951 abnormal breathing "irregular or atypical breathing pattern " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
Show

Allelic Composition: Ntrk2tm1Rohr/Ntrk2+
Genetic Background: Not Specified

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd247tm1Lov/Cd247tm1Lov,Fcer1gtm1Rav/Fcer1gtm1Rav
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ntrk2tm2Kln/Ntrk2tm2Kln,Tg(Cck-cre,-lacZ)1Mini/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

Allelic Composition: Ntrk2tm1Mini/Ntrk2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ntrk2tm2.1Mini/Ntrk2tm2.1Mini
Genetic Background: involves: 129P2/OlaHsd

 MP:0002090 abnormal vision "inability or decreased ability to see " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ntrk2tm1Rohr/Ntrk2+
Genetic Background: Not Specified

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Ntrk2tm2.1Mini/Ntrk2tm2.1Mini
Genetic Background: involves: 129P2/OlaHsd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ntrk2tm1Ddg/Ntrk2tm1Ddg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Itgb1tm1Mll/Itgb1tm1Mll,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ

 MP:0002184 abnormal innervation "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Itgb1tm1Mll/Itgb1tm1Mll,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ

 MP:0002207 abnormal long term potentiation "alterations in a persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxn1nu/Foxn1nu
Genetic Background: involves: BALB/c

Allelic Composition: Ntrk2tm2Kln/Ntrk2tm2Kln,Tg(Camk2a-cre)159Kln/?
Genetic Background: involves: 129S2/SvPas * CBA/J

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Itgb1tm1Mll/Itgb1tm1Mll,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ntrk2tm2Kln/Ntrk2tm2Kln,Tg(Cck-cre,-lacZ)1Mini/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0002638 abnormal pupillary reflex "alterations or failure of the pupil to change in diamater as a reflex response to any stimulus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ntrk2tm1Rohr/Ntrk2+
Genetic Background: Not Specified

 MP:0002664 decreased circulating adrenocorticotropin level "decreased concentration in the blood of the pituitary hormone that stimulates the secretion of adrenal cortical steroids and induces growth of the adrenal cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Mxi1tm1Rdp/Mxi1tm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0002665 decreased circulating corticosterone level "less than the normal blood concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Mxi1tm1Rdp/Mxi1tm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0002752 abnormal somatic nervous system morphology "malformation or absence of any of the cranial and spinal nerves or their ganglia or the peripheral sensory receptors" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ntrk2tm1Lfp/Ntrk2tm1Lfp
Genetic Background: involves: 129 * C57

Allelic Composition: Ntrk2tm1Bbd/Ntrk2tm1Bbd
Genetic Background: involves: 129S2/SvPas

 MP:0002790 decreased circulating follicle stimulating hormone level "less than expected blood concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Mxi1tm1Rdp/Mxi1tm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Ntrk2tm1Rohr/Ntrk2+
Genetic Background: Not Specified

 MP:0002797 thigmotaxis "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814]
Show

Allelic Composition: Cd247tm1Lov/Cd247tm1Lov,Fcer1gtm1Rav/Fcer1gtm1Rav
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Ntrk2tm2Kln/Ntrk2tm2Kln,Slc1a3tm1(cre/ERT2)Mgoe/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * SJL

Allelic Composition: Ntrk2tm1.1Tes/Ntrk2tm1.1Tes
Genetic Background: B6.129S1-Ntrk2tm1.1Tes

Allelic Composition: Ntrk2tm1.1Tes/Ntrk2+
Genetic Background: B6.129S1-Ntrk2tm1.1Tes

 MP:0002855 abnormal cochlear ganglion morphology "malformation, malfunction or absence of the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ntrk1tm1Par/Ntrk1tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002856 abnormal vestibular ganglion morphology "malformation of the group of neurons associated with the vestibular part of the eighth cranial nerve that are involved in equilibration" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ntrk1tm1Par/Ntrk1tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Apoetm1(APOE)Sfu/Apoetm1(APOE)Sfu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Foxn1nu/Foxn1nu
Genetic Background: involves: BALB/c

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ntrk2tm2Kln/Ntrk2tm2Kln,Tg(Cck-cre,-lacZ)1Mini/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0003212 susceptibility to age related obesity "increased probability of excessive weight gain that is progressive with age" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Ntrk2tm2Kln/Ntrk2tm2Kln,Tg(Cck-cre,-lacZ)1Mini/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

Allelic Composition: Ntrk2tm1Mini/Ntrk2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003243 abnormal dopaminergic neuron morphology "malformation or absence of the neurons that utilize dopamine as a neurotransmitter " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Itgb1tm1Mll/Itgb1tm1Mll,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ

 MP:0003308 abnormal cochlear sensory epithelium 
Show

Allelic Composition: Ntrk2tm1Bbd/Ntrk2tm1Kln
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mcl1tm1Dmta/Mcl1+,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Mcl1tm1Dmta Gt(ROSA)26Sortm9(cre/ESR1)Arte

 MP:0003357 impaired granulosa cell differentiation "atypical differentiation of the layer of small cells that forms the wall of an ovarian follicle" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:43075]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Mxi1tm1Rdp/Mxi1tm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0003409 decreased width of hypertrophic chondrocyte zone "decreased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ntrk2tm2Lfp/Ntrk2tm2Lfp,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0003461 abnormal response to novel object "altered investigative behavior from controls in reactions associated with exposing an animal to a novel object" [CFG:Center for Functional Genomics, Northwestern University]
Show

Allelic Composition: Ntrk2tm2.1Tes/Ntrk2tm2.1Tes
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003651 abnormal axon outgrowth "defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]
Show

Allelic Composition: Ntrk2tm2.1Tes/Ntrk2tm2.1Tes
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003871 abnormal myelin sheath morphology "malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ntrk2tm2Kln/Ntrk2tm2Kln,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Nr6a1tm1b(EUCOMM)Wtsi/Nr6a1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nr6a1tm1b(EUCOMM)Wtsi/Bay

 MP:0003986 small cochlear ganglion "reduced size of the cochlear ganglion or of the sensory neuron cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ntrk1tm1Par/Ntrk1tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Ntrk2tm1Lfp/Ntrk2tm1Lfp
Genetic Background: involves: 129 * C57

Allelic Composition: Ntrk2tm1Bbd/Ntrk2tm1Bbd
Genetic Background: involves: 129S2/SvPas

 MP:0003987 small vestibular ganglion "reduced size of the vestibular ganglion or of the sensory neuron cell bodies associated with the eighth cranial nerve" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ntrk1tm1Par/Ntrk1tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ntrk2tm1Lfp/Ntrk2tm1Lfp
Genetic Background: involves: 129 * C57

Allelic Composition: Ntrk2tm1Bbd/Ntrk2tm1Bbd
Genetic Background: involves: 129S2/SvPas

 MP:0003989 abnormal barrel cortex morphology "malformation of the discrete functional units of the somatosensory cortex that processes tactile information derived from the vibrissae" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ntrk2tm1Bbd/Ntrk2tm1Bbd
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ntrk2tm1Lfp/Ntrk2tm1Lfp
Genetic Background: involves: 129

 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ntrk2tm1Rohr/Ntrk2+
Genetic Background: Not Specified

 MP:0004220 abnormal peripheral nervous system regeneration "changes in the ability or inability of healthy peripheral nervous system tissue to regenerate following injury or disease" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mybtm1.1Jof/Mybtm1.1Jof
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004333 abnormal utricular macula morphology "any structural abnormalities in the neuroepithelial sensory receptor in the inferolateral wall of the utricle; hair cells of the neuroepithelium support the statoconial membrane and have terminal arborizations of vestibular nerve fibers around their bodies; normally sensitive to linear acceleration in the longitudinal axis of the body and to gravitational influences" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ntrk1tm1Par/Ntrk1tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004409 abnormal neuroepithelium of ampullary crest "any structural abnormality in the specialized sensory hair cells of the ampullary crest of the ampulla of each semicircular duct" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ntrk1tm1Par/Ntrk1tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004427 abnormal vestibular labyrinth "any structural abnormality in the portion of the membranous labyrinth concerned with the sense of equilibration (vs. the cochlear labyrinth, which is concerned with the sense of hearing) and innervated by the vestibular nerve; it is located within the semicircular canals and vestibule of the bony labyrinth, and consists of the utricle, saccule, and the semicircular, utriculosaccular, and endolymphatic ducts " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mcl1tm1Dmta/Mcl1+,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Mcl1tm1Dmta Gt(ROSA)26Sortm9(cre/ESR1)Arte

 MP:0004428 abnormal type I vestibular cell "any structural abnormality in the flask-shaped sensory cells of the maculae and cristae of the vestibular labyrinth of the inner ear, which are normally enclosed in calyx endings of afferent neurons; afferent and efferent nerve fibers of the vestibular nerve synapse with them; from the apical end of each cell a bundle of stereocilia and a kinocilium extend into the otolithic membrane of the maculae or the cupula of the cristae " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ntrk2tm1Bbd/Ntrk2tm1Kln
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

 MP:0004716 abnormal cochlear nerve morphology "any structural abnormality in the part of the vestibulocochlear nerve [CN VIII] peripheral to the cochlear root; composed of the central nerve processes of the bipolar neurons of the spiral ganglion, which have their peripheral processes on the four rows of neuroepithelial cells (hair cells) of the spiral organ" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln,Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004718 abnormal vestibular nerve morphology "any structural abnormality in the part of the vestibulocochlear nerve [CN VIII] peripheral to the vestibular root; it is composed of the central processes of bipolar neurons that have the terminals of their peripheral processes on the hair cells in the ampullae of the semicircular ducts and the maculae of the saccule and utricle, and cell bodies of the vestibular ganglion" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004736 abnormal distortion product otoacoustic emission "any abnormality in the sound produced by the cochlea in response to stimulation with 2 simultaneous tones of different frequencies; this measurement is particularly useful in assessing the functional state of OHCs" [eMedicine:http://www.emedicine.com/ent/topic372.htm, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ntrk2tm1Bbd/Ntrk2tm1Kln
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

 MP:0004747 abnormal cochlear OHC afferent innervation "any changes in the morphology or number of afferent terminals and/or their synapses in the cochlear OHC region" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ntrk1tm1Par/Ntrk1tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Ntrk2tm1Bbd/Ntrk2tm1Kln
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ntrk2tm2Kln/Ntrk2tm2Kln,Tg(Cck-cre,-lacZ)1Mini/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0005345 abnormal circulating corticosterone level "anomalous blood concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ntrk2tm1Rohr/Ntrk2+
Genetic Background: Not Specified

Allelic Composition: Ntrk2tm2Kln/Ntrk2tm2Kln,Tg(Cck-cre,-lacZ)1Mini/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0005455 increased weight gain "greater increase in body weight over existing weight when compared to the average increase in weight on the same diet, with equal energy (calorie) intake " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:42702]
Show

Allelic Composition: Ntrk2tm2Kln/Ntrk2tm2Kln,Tg(Cck-cre,-lacZ)1Mini/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nr6a1tm1b(EUCOMM)Wtsi/Nr6a1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nr6a1tm1b(EUCOMM)Wtsi/Bay

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Ntrk2tm2Kln/Ntrk2tm2Kln,Tg(Cck-cre,-lacZ)1Mini/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

Allelic Composition: Ntrk2tm1Mini/Ntrk2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mcl1tm1Dmta/Mcl1+,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Mcl1tm1Dmta Gt(ROSA)26Sortm9(cre/ESR1)Arte

Allelic Composition: Ntrk2tm2Kln/Ntrk2tm2Kln,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0006309 decreased retinal ganglion cell number "reduced number of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Angptl4tm1Lex/Angptl4tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0006396 decreased long bone epiphyseal plate size "reduced size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ntrk2tm2Lfp/Ntrk2tm2Lfp,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0008056 abnormal retinal ganglion cell morphology "any structural anomaly of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Angptl4tm1Lex/Angptl4tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Ntrk2tm1Lfr/Ntrk2+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Ntrk2tm2Lfr/Ntrk2tm2Lfr,Tg(Six3-cre)69Frty/?,Tg(Thy1-YFP)HJrs/?
Genetic Background: involves: C57BL/6 * CBA * DBA/2

 MP:0008106 decreased amacrine cell number "reduction in the number of one of the three types of interneurons found in the inner nuclear layer of the mature retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ntrk2tm1Rohr/Ntrk2+
Genetic Background: Not Specified

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoetm1(APOE)Sfu/Apoetm1(APOE)Sfu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

Allelic Composition: Ntrk2tm2Lfr/Ntrk2tm2Lfr,Tg(Six3-cre)69Frty/?,Tg(Thy1-YFP)HJrs/?
Genetic Background: involves: C57BL/6 * CBA * DBA/2

Allelic Composition: Ntrk2tm2Kln/Ntrk2tm2Kln,Slc1a3tm1(cre/ERT2)Mgoe/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * SJL

Allelic Composition: Ntrk2tm1.1Tes/Ntrk2tm1.1Tes
Genetic Background: B6.129S1-Ntrk2tm1.1Tes

 MP:0008294 abnormal zona fasciculata morphology "any structural anomaly of the wide middle zone of the adrenal cortex that produces cortisol (hydrocortisone)" [MESH:A06.407.071.140.950]
Show

Allelic Composition: Ntrk2tm2Kln/Ntrk2tm2Kln,Tg(Cck-cre,-lacZ)1Mini/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

Allelic Composition: Ntrk2tm1Mini/Ntrk2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008299 adrenal cortical hyperplasia "overdevelopment of the thick outer layer of the adrenal gland that produces and secretes steroid hormones, usually due to an increase in the number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ntrk2tm2Kln/Ntrk2tm2Kln,Tg(Cck-cre,-lacZ)1Mini/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

Allelic Composition: Ntrk2tm1Mini/Ntrk2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ntrk2tm2.1Tes/Ntrk2tm2.1Tes
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0008439 abnormal cortical plate morphology "any strucutral anomaly of the outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:1812236]
Show

Allelic Composition: Ntrk2tm2Kln/Ntrk2tm2Kln,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0008456 abnormal retinal rod cell outer segment morphology "any strucutral anomaly of the retinal rod cell region which contains stacks of membranous discs separate from the outer cell membrane that are rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ntrk2tm1Rohr/Ntrk2+
Genetic Background: Not Specified

 MP:0008572 abnormal Purkinje cell dendrite morphology "any strucutral anomaly of the Purkinje cell body projections with hundreds of parallel spiny branches reaching up into the molecular layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ntrk2tm1Bbd/Ntrk2tm1Bbd
Genetic Background: involves: 129S2/SvPas

 MP:0008911 induced hyperactivity "increased physical activity following stimulation such as handling, touching or noise" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ntrk2tm2Kln/Ntrk2tm2Kln,Tg(Penk-cre,-lacZ)1Mini/0
Genetic Background: involves: 129S2/SvPas

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
Show

Allelic Composition: Apoetm1(APOE)Sfu/Apoetm1(APOE)Sfu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nr6a1tm1b(EUCOMM)Wtsi/Nr6a1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nr6a1tm1b(EUCOMM)Wtsi/Bay

 MP:0009285 increased gonadal fat pad weight "greater than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ntrk2tm2Kln/Ntrk2tm2Kln,Tg(Cck-cre,-lacZ)1Mini/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0009286 increased abdominal fat pad weight "greater than average weight of the encapsulated adipose tissue in the abdomen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ntrk2tm2Kln/Ntrk2tm2Kln,Tg(Cck-cre,-lacZ)1Mini/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

Allelic Composition: Ntrk2tm1Mini/Ntrk2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009363 abnormal secondary ovarian follicle morphology "any structural abnormality in the ovarian follicle in which the primary oocyte attains its full size and is surrounded by an extracellular glycoprotein layer (zona pellucida) that separates it from a peripheral layer of follicular cells permeated by one or more fluid-filled antra; the primary oocyte occupies the cumulus oophorus while the theca of the follicle develops into internal and external layers" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Mxi1tm1Rdp/Mxi1tm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0009450 abnormal axon fasiculation "anomaly in the process by which axons form into bundles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mcl1tm1Dmta/Mcl1+,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: B6.Cg-Mcl1tm1Dmta Gt(ROSA)26Sortm9(cre/ESR1)Arte

Allelic Composition: Ntrk2tm2Kln/Ntrk2tm2Kln,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0009538 abnormal synapse morphology "any strucutral anomaly of the membrane junction site of a nerve cell to a target cell, such as another nerve cell, an effector cell, or a sensory receptor cell; transmission of nerve impulses may be mediated by chemical or by electrical means" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.850]
Show

Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ntrk2tm2Lfp/Ntrk2tm2Lfp,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0009754 enhanced behavioral response to cocaine "increased sensitivity to cocaine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ntrk2tm2Kln/Ntrk2tm2Kln,Tg(Penk-cre,-lacZ)1Mini/0
Genetic Background: involves: 129S2/SvPas

 MP:0009772 abnormal retinal development "anomaly in any of the steps during embryogenesis that produce the nerve layer lining in the back of the eye which senses light, and creates impulses that travel through the optic nerve to the brain" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ntrk2tm1Rohr/Ntrk2+
Genetic Background: Not Specified

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ntrk2tm2Kln/Ntrk2tm2Kln,Slc1a3tm1(cre/ERT2)Mgoe/?,Gt(ROSA)26Sortm1Sor/?
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * SJL

Allelic Composition: Ntrk2tm2.1Mini/Ntrk2tm2.1Mini
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Ntrk2tm2Kln/Ntrk2tm2Kln,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ntrk2tm2Kln/Ntrk2tm2Kln,Tg(Cck-cre,-lacZ)1Mini/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0010769 abnormal survival "deviation from the expected viability or life span of an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sptbn4qv/Sptbn4qv
Genetic Background: either: (involves: BALB/c) or (involves: C57BL/10)

Allelic Composition: Ntrk2tm3.1(cre/ERT2)Ddg/Ntrk2tm3.1(cre/ERT2)Ddg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Mxi1tm1Rdp/Mxi1tm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Ntrk2tm1Rohr/Ntrk2tm1Rohr
Genetic Background: involves: ICR

Allelic Composition: Ntrk2tm1Lfp/Ntrk2tm1Lfp
Genetic Background: involves: 129 * C57

Allelic Composition: Ntrk2tm1Bbd/Ntrk2tm1Bbd
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Ntrk2tm2.1Mini/Ntrk2tm2.1Mini
Genetic Background: involves: 129P2/OlaHsd

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ntrk2tm2Lfp/Ntrk2tm2Lfp,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Ttm1(cre/ERT2)Hssk/T+
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj * ICR

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Ntrk1tm1Par/Ntrk1tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Nr6a1tm1b(EUCOMM)Wtsi/Nr6a1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nr6a1tm1b(EUCOMM)Wtsi/Bay

 MP:0011448 decreased dopaminergic neuron number "fewer than normal numbers of the neurons that utilize dopamine as a neurotransmitter" [MGI:smb]
Show

Allelic Composition: Itgb1tm1Mll/Itgb1tm1Mll,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ

 MP:0011451 increased susceptibility to dopaminergic neuron neurotoxicity "greater than normal amount of dopaminergic neuronal cell death following exposure to a neurotoxic compound, such as MPTP-induced cell death occurring through interference in mitochondrial metabolism" [MGI:csmith]
Show

Allelic Composition: Itgb1tm1Mll/Itgb1tm1Mll,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ

 MP:0011987 abnormal GABAergic neuron physiology "any functional anomaly of the neurons that utilize gamma-aminobutyric acid as a neurotransmitter" [PMID:8787741]
Show

Allelic Composition: Ntrk2tm2Kln/Ntrk2tm2Kln,Tg(Cck-cre,-lacZ)1Mini/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0020467 abnormal circadian behavior "any anomaly in the specific behavior of an organism that recurs with a regularity of approximately 24 hours" [GO:0048512]
Show

Allelic Composition: Ntrk2tm2Kln/Ntrk2tm2Kln,Tg(Cck-cre,-lacZ)1Mini/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000016933 Plcg1 / Q62077 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 / P19174* / phospholipase C gamma 1*  / complex / reaction
 ENSMUSG00000020170 Frs2 / Q8C180 / Fibroblast growth factor receptor substrate 2 / Q8WU20*  / complex / reaction
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / complex
 ENSMUSG00000031714 Gab1 / Q9QYY0 / GRB2-associated-binding protein 1 / Q13480*  / complex
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / reaction / complex
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / complex
 ENSMUSG00000074121 Ntf5 / Q80VU4 / Neurotrophin-4 / NTF4* / P34130*  / complex
 ENSMUSG00000048482 Bdnf / P21237 / Brain-derived neurotrophic factor / P23560*  / complex
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / complex
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex
 ENSMUSG00000055254 Ntrk2 / P15209 / BDNF/NT-3 growth factors receptor / Q16620* / neurotrophic receptor tyrosine kinase 2*  / complex
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr