ENSMUSG00000074121


Mus musculus

Features
Gene ID: ENSMUSG00000074121
  
Biological name :Ntf5
  
Synonyms : Neurotrophin-4 / Ntf5 / Q80VU4
  
Possible biological names infered from orthology : NTF4 / P34130
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: B3
Gene start: 45413695
Gene end: 45417179
  
Corresponding Affymetrix probe sets: 10552938 (MoGene1.0st)   1440353_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000057916
Ensembl peptide - ENSMUSP00000148209
NCBI entrez gene - 78405     See in Manteia.
MGI - MGI:97381
RefSeq - XM_011250919
RefSeq - NM_198190
RefSeq - XM_006541312
RefSeq - XM_006541313
RefSeq Peptide - NP_937833
swissprot - A0A1B0GT57
swissprot - Q80VU4
Ensembl - ENSMUSG00000074121
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NTF4ENSG00000225950Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bdnf / P21237 / Brain-derived neurotrophic factor / P23560*ENSMUSG0000004848243
Ntf3 / P20181 / Neurotrophin-3 / P20783*ENSMUSG0000004910740
Ngf / P01139 / Beta-nerve growth factor / P01138* / nerve growth factor*ENSMUSG0000002785936


Protein motifs (from Interpro)
Interpro ID Name
 IPR002072  Nerve growth factor-related
 IPR019846  Nerve growth factor conserved site
 IPR020408  Nerve growth factor-like
 IPR020432  Neurotrophin-4
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0007267 cell-cell signaling IBA
 biological_processGO:0007402 ganglion mother cell fate determination IMP
 biological_processGO:0007616 long-term memory IMP
 biological_processGO:0008052 sensory organ boundary specification IMP
 biological_processGO:0008344 adult locomotory behavior IMP
 biological_processGO:0008544 epidermis development IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0042490 mechanoreceptor differentiation IGI
 biological_processGO:0043524 negative regulation of neuron apoptotic process IBA
 biological_processGO:0045664 regulation of neuron differentiation IBA
 biological_processGO:0048812 neuron projection morphogenesis IBA
 biological_processGO:0060384 innervation IDA
 biological_processGO:0060548 negative regulation of cell death IDA
 biological_processGO:0061193 taste bud development IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0031410 cytoplasmic vesicle IBA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005166 neurotrophin p75 receptor binding TAS
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
Activated NTRK2 signals through PLCG1
Activated NTRK2 signals through FRS2 and FRS3


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000427 abnormal hair cycle "aberrant growth or asynchronous timing of the hair growth " [J:65302]
Show

Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

 MP:0000565 oligodactyly "congenital condition in which some digits or parts of digits are missing" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Nr6a1tm1b(EUCOMM)Wtsi/Nr6a1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nr6a1tm1b(EUCOMM)Wtsi/Bay

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Nr6a1tm1b(EUCOMM)Wtsi/Nr6a1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nr6a1tm1b(EUCOMM)Wtsi/Bay

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
Show

Allelic Composition: Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Bdnftm1Par/Bdnftm1Par,Ntf5tm1Par/Ntf5tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000964 small dorsal root ganglia "reduced size of the dorsal root ganglia" [J:17123]
Show

Allelic Composition: Ntf3tm1Par/Ntf3tm1Par,Ntf5tm1Par/Ntf5tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Ntf5tm1Par/Ntf5tm1Par,Ntrk1tm1Par/Ntrk1tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000966 reduced sensory neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

Allelic Composition: Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Bdnftm1Gdy/Bdnftm1Gdy,Ntf5tm1Gdy/Ntf5tm1Gdy
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Bdnftm1Jae/Bdnftm1Jae,Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
Show

Allelic Composition: Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0001021 small L4 ganglion "reduced size of L4 ganglion" [J:17792]
Show

Allelic Composition: Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0001052 abnormal muscle innervation "malfomation or misprojection of sensory or motor nerves to targets in muscle" [J:75958]
Show

Allelic Composition: Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0001065 abnormal trigeminal nerve morphology "malformed chief sensory nerve of the face and motor nerve of the muscles of mastication; has three major divisions: ophthalmic, maxillary and mandibular " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:33038]
Show

Allelic Composition: Bdnftm1Jae/Bdnftm1Jae,Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0001083 small geniculate ganglion "reduced size of the geniculate ganglion or decreased size of sensory neuron cell bodies associated with the facial nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

Allelic Composition: Bdnftm1Jae/Bdnftm1Jae,Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0001085 small petrosal ganglion "reduced size of the petrosal ganglion" [J:25565]
Show

Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

Allelic Composition: Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Bdnftm1Gdy/Bdnftm1Gdy,Ntf5tm1Gdy/Ntf5tm1Gdy
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Bdnftm1Jae/Bdnftm1Jae,Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0001088 small nodose ganglion "reduced size of the nodose ganglion" [J:25565, J:17123]
Show

Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

Allelic Composition: Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Bdnftm1Gdy/Bdnftm1Gdy,Ntf5tm1Gdy/Ntf5tm1Gdy
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Bdnftm1Jae/Bdnftm1Jae,Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0001093 small trigeminal ganglion "reduced size of the trigeminal ganglion" [J:25565, J:17123]
Show

Allelic Composition: Ntf3tm1Par/Ntf3tm1Par,Ntf5tm1Par/Ntf5tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Bdnftm1Gdy/Bdnftm1Gdy,Ntf5tm1Gdy/Ntf5tm1Gdy
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Bdnftm1Jae/Bdnftm1Jae,Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0001200 thick skin "greater depth of skin " [J:47225]
Show

Allelic Composition: Ntf3tm1Par/Ntf3tm1Par
Genetic Background: involves: 129S1/Sv

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Bdnftm1Gdy/Bdnftm1Gdy,Ntf5tm1Gdy/Ntf5tm1Gdy
Genetic Background: involves: 129P2/OlaHsd

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Bdnftm1Jae/Bdnftm1Jae,Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bdnftm1Gdy/Bdnftm1Gdy,Ntf5tm1Gdy/Ntf5tm1Gdy
Genetic Background: involves: 129P2/OlaHsd

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
Show

Allelic Composition: Bdnftm1Gdy/Bdnftm1Gdy,Ntf5tm1Gdy/Ntf5tm1Gdy
Genetic Background: involves: 129P2/OlaHsd

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
Show

Allelic Composition: Bdnftm1Jae/Bdnftm1Jae,Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
Show

Allelic Composition: Nr6a1tm1b(EUCOMM)Wtsi/Nr6a1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nr6a1tm1b(EUCOMM)Wtsi/Bay

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Bdnftm1Gdy/Bdnftm1Gdy,Ntf5tm1Gdy/Ntf5tm1Gdy
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Bdnftm1Jae/Bdnftm1Jae,Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Nr6a1tm1b(EUCOMM)Wtsi/Nr6a1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nr6a1tm1b(EUCOMM)Wtsi/Bay

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nr6a1tm1b(EUCOMM)Wtsi/Nr6a1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nr6a1tm1b(EUCOMM)Wtsi/Bay

 MP:0003204 decreased neuron apoptosis "decrease in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Ngfrtm1Jae/Ngfrtm1Jae,Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0003987 small vestibular ganglion "reduced size of the vestibular ganglion or of the sensory neuron cell bodies associated with the eighth cranial nerve" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Bdnftm1Gdy/Bdnftm1Gdy,Ntf5tm1Gdy/Ntf5tm1Gdy
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Bdnftm1Jae/Bdnftm1Jae,Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nr6a1tm1b(EUCOMM)Wtsi/Nr6a1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nr6a1tm1b(EUCOMM)Wtsi/Bay

 MP:0009141 increased prepulse inhibition "increase in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nr6a1tm1b(EUCOMM)Wtsi/Nr6a1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nr6a1tm1b(EUCOMM)Wtsi/Bay

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Bdnftm1Par/Bdnftm1Par,Ntf5tm1Par/Ntf5tm1Par
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Bdnftm1Gdy/Bdnftm1Gdy,Ntf5tm1Gdy/Ntf5tm1Gdy
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Bdnftm1Jae/Bdnftm1Jae,Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000018697 Aatf / Q9JKX4 / apoptosis antagonizing transcription factor / Q9NY61*  / reaction / complex
 ENSMUSG00000016933 Plcg1 / Q62077 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 / P19174* / phospholipase C gamma 1*  / complex
 ENSMUSG00000020170 Frs2 / Q8C180 / Fibroblast growth factor receptor substrate 2 / Q8WU20*  / complex / reaction
 ENSMUSG00000027859 Ngf / P01139 / Beta-nerve growth factor / P01138* / nerve growth factor*  / reaction / complex
 ENSMUSG00000048482 Bdnf / P21237 / Brain-derived neurotrophic factor / P23560*  / complex / reaction
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / complex
 ENSMUSG00000055254 Ntrk2 / P15209 / BDNF/NT-3 growth factors receptor / Q16620* / neurotrophic receptor tyrosine kinase 2*  / complex
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex
 ENSMUSG00000025151 Maged1 / Q9QYH6 / Melanoma-associated antigen D1 / Q9Y5V3* / MAGE family member D1*  / reaction / complex
 ENSMUSG00000074121 Ntf5 / Q80VU4 / Neurotrophin-4 / NTF4* / P34130*  / reaction / complex
 ENSMUSG00000049107 Ntf3 / P20181 / Neurotrophin-3 / P20783*  / complex / reaction






 

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