ENSMUSG00000025151


Mus musculus

Features
Gene ID: ENSMUSG00000025151
  
Biological name :Maged1
  
Synonyms : Maged1 / Melanoma-associated antigen D1 / Q9QYH6
  
Possible biological names infered from orthology : MAGE family member D1 / Q9Y5V3
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: C3
Gene start: 94535474
Gene end: 94542143
  
Corresponding Affymetrix probe sets: 10605766 (MoGene1.0st)   1450062_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026142
NCBI entrez gene - 94275     See in Manteia.
MGI - MGI:1930187
RefSeq - NM_019791
RefSeq Peptide - NP_062765
swissprot - Q9QYH6
Ensembl - ENSMUSG00000025151
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ndnl2ENSDARG00000058212Danio rerio
 MAGED1ENSG00000179222Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tro / trophinin / Q12816*ENSMUSG0000002527230
Maged2 / Mus musculus melanoma antigen, family D, 2 (Maged2), transcript variant 4, mRNA. / Q9UNF1* / MAGE family member D2*ENSMUSG0000002526830
Magel2 / Q9QZ04 / MAGE-like protein 2 / Q9UJ55* / MAGE family member L2*ENSMUSG0000005697219
Magee1 / Q6PCZ4 / Melanoma-associated antigen E1 / Q9HCI5* / MAGE family member E1*ENSMUSG0000003122717
Gm8914 / Q8N7X4* / MAGEB6* / MAGEB6B* / MAGE family member B6* / MAGE family member B6B*ENSMUSG0000009607213
Gm5072 / Q8N7X4* / MAGEB6* / MAGEB6B* / MAGE family member B6* / MAGE family member B6B*ENSMUSG0000009486113
Magea10 / P43363* / MAGE family member A10*ENSMUSG0000004345313
Nsmce3 / Q9CPR8 / Non-structural maintenance of chromosomes element 3 homolog / Q96MG7* / NSE3 homolog, SMC5-SMC6 complex component*ENSMUSG0000007052013
Mageb4 / A2A9R3 / Melanoma-associated antigen B4 / P43366* / MAGEB1* / MAGEB2* / O15479* / O15481* / MAGE family member B1* / MAGE family member B4* / MAGE family member B2*ENSMUSG0000003542713
4933402E13Rik / RIKEN cDNA 4933402E13 geneENSMUSG0000004533013
Magee2 / MAGE family member E2 / Q8TD90*ENSMUSG0000003122413
Q8BQR7 / Mageb18 / Melanoma-associated antigen B18 / Q96M61* / MAGE family member B18*ENSMUSG0000006764912
4930550L24Rik / RIKEN cDNA 4930550L24 gene / MAGEC2* / MAGEC3* / Q8TD91* / Q9UBF1* / MAGEC1* / O60732* / MAGE family member C1* / MAGE family member C2* / MAGE family member C3*ENSMUSG0000004618012
Magea5 / P43363* / MAGEA10* / MAGE family member A10*ENSMUSG0000007934912
Q9CWV4 / Mageb16 / Melanoma-associated antigen B16 / A2A368* / MAGE family member B16*ENSMUSG0000004694212
Magea6 / melanoma antigen, family A, 6 / P43363* / MAGEA10* / MAGE family member A10*ENSMUSG0000006372812
Magea3 / P43363* / MAGEA10* / MAGE family member A10*ENSMUSG0000009419612
Magea4 / P43363* / MAGEA10* / MAGE family member A10*ENSMUSG0000003334312
Magea8 / melanoma antigen, family A, 8 / P43363* / MAGEA10* / MAGE family member A10*ENSMUSG0000007935012
3830417A13Rik / RIKEN cDNA 3830417A13 gene / P43363* / MAGEA10* / MAGE family member A10*ENSMUSG0000003117911


Protein motifs (from Interpro)
Interpro ID Name
 IPR002190  MAGE homology domain
 IPR030083  Melanoma-associated antigen D1
 IPR037445  Melanoma-associated antigen


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0032922 circadian regulation of gene expression IMP
 biological_processGO:0042752 regulation of circadian rhythm IMP
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043406 positive regulation of MAP kinase activity IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IEA
 biological_processGO:0090190 positive regulation of branching involved in ureteric bud morphogenesis IMP
 biological_processGO:2001235 positive regulation of apoptotic signaling pathway IMP
 cellular_componentGO:0000785 chromatin IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0003713 transcription coactivator activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001011 abnormal superior cervical ganglion morphology "malformation or absence of the group of neurons that is the largest of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Mirc30tm1.1Rdf/Mirc30tm1.1Rdf
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0001361 social withdrawal "mice remain physically distant, do not sleep in piles with cagemates" [J:57125]
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Allelic Composition: Nr1d1tm1.1Rev/Nr1d1tm1.1Rev,Nr1d2tm1.1Rev/Nr1d2tm1.1Rev,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: BALB/cJ * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Maged1tm1Tnab/Maged1tm1Tnab
Genetic Background: B6.129P2-Maged1tm1Tnab

Allelic Composition: Maged1tm1Tnab/Maged1+
Genetic Background: B6.129P2-Maged1tm1Tnab

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Nr1d1tm1.1Rev/Nr1d1tm1.1Rev,Nr1d2tm1.1Rev/Nr1d2tm1.1Rev,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: BALB/cJ * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Maged1tm1Tnab/Maged1tm1Tnab
Genetic Background: B6.129P2-Maged1tm1Tnab

Allelic Composition: Maged1tm1Tnab/Maged1+
Genetic Background: B6.129P2-Maged1tm1Tnab

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
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Allelic Composition: Nr1d1tm1.1Rev/Nr1d1tm1.1Rev,Nr1d2tm1.1Rev/Nr1d2tm1.1Rev,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: BALB/cJ * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Maged1tm1Tnab/Maged1tm1Tnab
Genetic Background: B6.129P2-Maged1tm1Tnab

Allelic Composition: Maged1tm1Tnab/Maged1+
Genetic Background: B6.129P2-Maged1tm1Tnab

 MP:0002573 behavioral despair "depression assayed by reduced escape attempts and/or immobility when placed in a stressful situation such as a forced swim test or a suspension test; or failure to seek pleasurable stimuli" [J:80395]
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Allelic Composition: Nr1d1tm1.1Rev/Nr1d1tm1.1Rev,Nr1d2tm1.1Rev/Nr1d2tm1.1Rev,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: BALB/cJ * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Maged1tm1Tnab/Maged1tm1Tnab
Genetic Background: B6.129P2-Maged1tm1Tnab

Allelic Composition: Maged1tm1Tnab/Maged1+
Genetic Background: B6.129P2-Maged1tm1Tnab

 MP:0003204 decreased neuron apoptosis "decrease in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Mirc30tm1.1Rdf/Mirc30tm1.1Rdf
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0005253 abnormal eye physiology "anomalous function and/or activity of the ocular system or any of its parts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Mirc30tm1.1Rdf/Mirc30tm1.1Rdf
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0005322 abnormal serotonin level "anomalous concentration of biochemical messenger and regulator, found in the CNS, g.i. tract, and produced by platelets; it mediates neurotransmission, g.i. motility, hemostasis, and cardiovascular integrity " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nr1d1tm1.1Rev/Nr1d1tm1.1Rev,Nr1d2tm1.1Rev/Nr1d2tm1.1Rev,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: BALB/cJ * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Maged1tm1Tnab/Maged1tm1Tnab
Genetic Background: B6.129P2-Maged1tm1Tnab

 MP:0008752 abnormal tumor necrosis factor level "deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Mirc30tm1.1Rdf/Mirc30tm1.1Rdf
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0008859 abnormal hair cycle catagen phase "anomaly in the phase of the hair growth cycle during which cell proliferation ceases, the hair follicle shortens, and an anchored hair is produced" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Mirc30tm1.1Rdf/Mirc30tm1.1Rdf
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0009253 abnormal sympathetic neuron physiology "any functional anomaly of any of the neurons of the part of the autonomic nervous system that innervates smooth muscle, cardiac muscle and glands and mediates the body s response to stressful situations" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Mirc30tm1.1Rdf/Mirc30tm1.1Rdf
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0009710 anhedonia "inability to experience pleasure in response to normally pleasurable stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr1d1tm1.1Rev/Nr1d1tm1.1Rev,Nr1d2tm1.1Rev/Nr1d2tm1.1Rev,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: BALB/cJ * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Maged1tm1Tnab/Maged1tm1Tnab
Genetic Background: B6.129P2-Maged1tm1Tnab

 MP:0010069 increased serotonin concentration "increase in the amount per unit of biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets that mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Nr1d1tm1.1Rev/Nr1d1tm1.1Rev,Nr1d2tm1.1Rev/Nr1d2tm1.1Rev,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: BALB/cJ * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Maged1tm1Tnab/Maged1tm1Tnab
Genetic Background: B6.129P2-Maged1tm1Tnab

 MP:0010070 decreased serotonin concentration "reduction in the amount per unit of biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets that mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Nr1d1tm1.1Rev/Nr1d1tm1.1Rev,Nr1d2tm1.1Rev/Nr1d2tm1.1Rev,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: BALB/cJ * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Maged1tm1Tnab/Maged1tm1Tnab
Genetic Background: B6.129P2-Maged1tm1Tnab

 MP:0020467 abnormal circadian behavior "any anomaly in the specific behavior of an organism that recurs with a regularity of approximately 24 hours" [GO:0048512]
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Allelic Composition: Gt(ROSA)26Sortm1(MAML1)Wsp/Gt(ROSA)26Sor+,Tg(KRT14-rtTA)F42Efu/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6 * FVB

Allelic Composition: Maged1tm1Xgao/Maged1tm1Xgao
Genetic Background: B6.Cg-Maged1tm1Xgao

 MP:0020470 shortened circadian behavior period "decrease in the cycle length of a behavior expressed when exposed to constant conditions without temporal cues" [MGI:smb]
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Allelic Composition: Gt(ROSA)26Sortm1(MAML1)Wsp/Gt(ROSA)26Sor+,Tg(KRT14-rtTA)F42Efu/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6 * FVB

Allelic Composition: Maged1tm1Xgao/Maged1tm1Xgao
Genetic Background: B6.Cg-Maged1tm1Xgao

Allelic Composition: Maged1tm1Xgao/Maged1+
Genetic Background: B6.Cg-Maged1tm1Xgao

 MP:0020476 abnormal circardian behavior entrainment "anomaly in the synchronization of a circadian behavior to environmental time cues such as light" [GO:0009649]
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Allelic Composition: Gt(ROSA)26Sortm1(MAML1)Wsp/Gt(ROSA)26Sor+,Tg(KRT14-rtTA)F42Efu/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6 * FVB

Allelic Composition: Maged1tm1Xgao/Maged1tm1Xgao
Genetic Background: B6.Cg-Maged1tm1Xgao

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000018697 Aatf / Q9JKX4 / apoptosis antagonizing transcription factor / Q9NY61*  / complex / reaction
 ENSMUSG00000025876 Unc5a / Q8K1S4 / unc-5 netrin receptor A / Q6ZN44*  / reaction / complex
 ENSMUSG00000027859 Ngf / P01139 / Beta-nerve growth factor / P01138* / nerve growth factor*  / complex / reaction
 ENSMUSG00000074121 Ntf5 / Q80VU4 / Neurotrophin-4 / NTF4* / P34130*  / complex / reaction
 ENSMUSG00000049107 Ntf3 / P20181 / Neurotrophin-3 / P20783*  / complex / reaction
 ENSMUSG00000048482 Bdnf / P21237 / Brain-derived neurotrophic factor / P23560*  / complex / reaction






 

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