ENSG00000179222


Homo sapiens

Features
Gene ID: ENSG00000179222
  
Biological name :MAGED1
  
Synonyms : MAGED1 / MAGE family member D1 / Q9Y5V3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: 1
Band: p11.22
Gene start: 51803007
Gene end: 51902357
  
Corresponding Affymetrix probe sets: 209014_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000325333
Ensembl peptide - ENSP00000364847
Ensembl peptide - ENSP00000364874
Ensembl peptide - ENSP00000364927
NCBI entrez gene - 9500     See in Manteia.
OMIM - 300224
RefSeq - XM_017029980
RefSeq - NM_001005332
RefSeq - NM_001005333
RefSeq - NM_006986
RefSeq - XM_011530835
RefSeq - XM_017029978
RefSeq - XM_017029979
RefSeq Peptide - NP_001005332
RefSeq Peptide - NP_001005333
RefSeq Peptide - NP_008917
swissprot - Q9Y5V3
Ensembl - ENSG00000179222
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ndnl2ENSDARG00000058212Danio rerio
 Maged1ENSMUSG00000025151Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MAGED4 / Q96JG8 / MAGE family member D4ENSG0000015454539
Q96JG8 / MAGED4B / MAGE family member D4BENSG0000018724339
TRO / Q12816 / trophininENSG0000006744530
MAGED2 / Q9UNF1 / MAGE family member D2ENSG0000010231629
MAGEL2 / Q9UJ55 / MAGE family member L2ENSG0000025458523
MAGEE1 / Q9HCI5 / MAGE family member E1ENSG0000019893418
MAGEF1 / Q9HAY2 / MAGE family member F1ENSG0000017738313
A2A368 / MAGEB16 / MAGE family member B16ENSG0000018902313
MAGEB6B / MAGE family member B6BENSG0000023203013
MAGEB1 / P43366 / MAGE family member B1ENSG0000021410713
MAGEB3 / O15480 / MAGE family member B3ENSG0000019879813
A8MXT2 / MAGEB17 / MAGE family member B17ENSG0000018279813
P43363 / MAGEA10 / MAGE family member A10ENSG0000012426013
MAGEB4 / O15481 / MAGE family member B4ENSG0000012028913
Q96M61 / MAGEB18 / MAGE family member B18ENSG0000017677413
MAGEB6 / Q8N7X4 / MAGE family member B6ENSG0000017674612
MAGEA4 / P43358 / MAGE family member A4ENSG0000014738112
Q96LZ2 / MAGEB10 / MAGE family member B10ENSG0000017768912
P43364 / MAGEA11 / MAGE family member A11ENSG0000018524712
NDN / Q99608 / necdin, MAGE family memberENSG0000018263612


Protein motifs (from Interpro)
Interpro ID Name
 IPR002190  MAGE homology domain
 IPR030083  Melanoma-associated antigen D1
 IPR037445  Melanoma-associated antigen


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated TAS
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0032922 circadian regulation of gene expression ISS
 biological_processGO:0042752 regulation of circadian rhythm IEA
 biological_processGO:0042981 regulation of apoptotic process TAS
 biological_processGO:0043406 positive regulation of MAP kinase activity IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IDA
 biological_processGO:0090190 positive regulation of branching involved in ureteric bud morphogenesis IEA
 biological_processGO:2001235 positive regulation of apoptotic signaling pathway IEA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0032991 protein-containing complex IDA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
via Dependence Receptors in the absence of ligand


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000107643 MAPK8 / P45983 / mitogen-activated protein kinase 8  / reaction
 ENSG00000113763 UNC5A / Q6ZN44 / unc-5 netrin receptor A  / reaction / complex
 ENSG00000134259 NGF / P01138 / nerve growth factor  / complex / reaction
 ENSG00000064300 NGFR / P08138 / nerve growth factor receptor  / reaction / complex
 ENSG00000275700 AATF / Q9NY61 / apoptosis antagonizing transcription factor  / reaction / complex






 

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