ENSG00000113763


Homo sapiens

Features
Gene ID: ENSG00000113763
  
Biological name :UNC5A
  
Synonyms : Q6ZN44 / UNC5A / unc-5 netrin receptor A
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q35.2
Gene start: 176810477
Gene end: 176880898
  
Corresponding Affymetrix probe sets: 236448_at (Human Genome U133 Plus 2.0 Array)   243833_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000332737
Ensembl peptide - ENSP00000421795
Ensembl peptide - ENSP00000424067
NCBI entrez gene - 90249     See in Manteia.
OMIM - 607869
RefSeq - XM_011534686
RefSeq - NM_133369
RefSeq - XM_006714927
RefSeq - XM_006714928
RefSeq Peptide - NP_588610
swissprot - Q6ZN44
swissprot - H0Y9G2
swissprot - H0Y8R2
Ensembl - ENSG00000113763
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 unc5aENSDARG00000099034Danio rerio
 UNC5AENSGALG00000018998Gallus gallus
 Unc5aENSMUSG00000025876Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
UNC5C / O95185 / unc-5 netrin receptor CENSG0000018216854
UNC5B / Q8IZJ1 / unc-5 netrin receptor BENSG0000010773152
UNC5D / Q6UXZ4 / unc-5 netrin receptor DENSG0000015668744
Q8IV45 / UNC5CL / unc-5 family C-terminal likeENSG0000012460214


Protein motifs (from Interpro)
Interpro ID Name
 IPR000488  Death domain
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR000906  ZU5 domain
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR011029  Death-like domain superfamily
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR033772  UPA domain
 IPR036179  Immunoglobulin-like domain superfamily
 IPR036383  Thrombospondin type-1 (TSP1) repeat superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007411 axon guidance TAS
 biological_processGO:0031175 neuron projection development ISS
 biological_processGO:0033564 anterior/posterior axon guidance IEA
 biological_processGO:0038007 netrin-activated signaling pathway IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031226 intrinsic component of plasma membrane ISS
 cellular_componentGO:0032589 neuron projection membrane ISS
 cellular_componentGO:0032809 neuronal cell body membrane ISS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0005042 netrin receptor activity IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Netrin-1 signaling
Netrin mediated repulsion signals
via Dependence Receptors in the absence of ligand


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000065320 NTN1 / O95631 / netrin 1  / reaction / complex
 ENSG00000187323 DCC / P43146 / DCC netrin 1 receptor  / complex / reaction
 ENSG00000164305 CASP3 / P42574 / caspase 3  / reaction
 ENSG00000074527 NTN4 / Q9HB63 / netrin 4  / reaction / complex
 ENSG00000179222 MAGED1 / Q9Y5V3 / MAGE family member D1  / reaction / complex






 

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