ENSG00000182168


Homo sapiens

Features
Gene ID: ENSG00000182168
  
Biological name :UNC5C
  
Synonyms : O95185 / UNC5C / unc-5 netrin receptor C
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: q22.3
Gene start: 95162504
Gene end: 95549206
  
Corresponding Affymetrix probe sets: 1555341_at (Human Genome U133 Plus 2.0 Array)   1555342_a_at (Human Genome U133 Plus 2.0 Array)   206189_at (Human Genome U133 Plus 2.0 Array)   227838_at (Human Genome U133 Plus 2.0 Array)   240958_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000425117
Ensembl peptide - ENSP00000483905
Ensembl peptide - ENSP00000426924
Ensembl peptide - ENSP00000426153
Ensembl peptide - ENSP00000406022
NCBI entrez gene - 8633     See in Manteia.
OMIM - 603610
RefSeq - XM_005263321
RefSeq - XM_017008790
RefSeq - XM_017008789
RefSeq - NM_003728
RefSeq Peptide - NP_003719
swissprot - O95185
swissprot - E0CX15
swissprot - A0A087X152
swissprot - D6RE16
Ensembl - ENSG00000182168
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch73-72b7.1ENSDARG00000099133Danio rerio
 unc5cENSDARG00000087341Danio rerio
 UNC5CENSGALG00000012219Gallus gallus
 Unc5cENSMUSG00000059921Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
UNC5B / Q8IZJ1 / unc-5 netrin receptor BENSG0000010773164
UNC5D / Q6UXZ4 / unc-5 netrin receptor DENSG0000015668750
UNC5A / Q6ZN44 / unc-5 netrin receptor AENSG0000011376349
Q8IV45 / UNC5CL / unc-5 family C-terminal likeENSG0000012460214


Protein motifs (from Interpro)
Interpro ID Name
 IPR000488  Death domain
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR000906  ZU5 domain
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR011029  Death-like domain superfamily
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR021157  Cytochrome c1, transmembrane anchor, C-terminal
 IPR033772  UPA domain
 IPR036179  Immunoglobulin-like domain superfamily
 IPR036383  Thrombospondin type-1 (TSP1) repeat superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007411 axon guidance TAS
 biological_processGO:0007420 brain development TAS
 biological_processGO:0030334 regulation of cell migration IEA
 biological_processGO:0033564 anterior/posterior axon guidance IEA
 biological_processGO:0038007 netrin-activated signaling pathway IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0005042 netrin receptor activity IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Netrin mediated repulsion signals


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000065320 NTN1 / O95631 / netrin 1  / complex / reaction
 ENSG00000187323 DCC / P43146 / DCC netrin 1 receptor  / complex / reaction
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / reaction
 ENSG00000179295 PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11  / complex / reaction






 

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