ENSG00000107731


Homo sapiens

Features
Gene ID: ENSG00000107731
  
Biological name :UNC5B
  
Synonyms : Q8IZJ1 / UNC5B / unc-5 netrin receptor B
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: q22.1
Gene start: 71212570
Gene end: 71302864
  
Corresponding Affymetrix probe sets: 213100_at (Human Genome U133 Plus 2.0 Array)   226899_at (Human Genome U133 Plus 2.0 Array)   41856_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000334329
Ensembl peptide - ENSP00000362288
NCBI entrez gene - 219699     See in Manteia.
OMIM - 607870
RefSeq - XM_017015835
RefSeq - NM_001244889
RefSeq - NM_170744
RefSeq - XM_011539453
RefSeq - XM_017015834
RefSeq Peptide - NP_001231818
RefSeq Peptide - NP_734465
swissprot - Q8IZJ1
Ensembl - ENSG00000107731
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 unc5bENSDARG00000033327Danio rerio
 UNC5BENSGALG00000004569Gallus gallus
 Unc5bENSMUSG00000020099Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
UNC5C / O95185 / unc-5 netrin receptor CENSG0000018216863
UNC5D / Q6UXZ4 / unc-5 netrin receptor DENSG0000015668752
UNC5A / Q6ZN44 / unc-5 netrin receptor AENSG0000011376346
Q8IV45 / UNC5CL / unc-5 family C-terminal likeENSG0000012460214


Protein motifs (from Interpro)
Interpro ID Name
 IPR000488  Death domain
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR000906  ZU5 domain
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR011029  Death-like domain superfamily
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR033772  UPA domain
 IPR036179  Immunoglobulin-like domain superfamily
 IPR036383  Thrombospondin type-1 (TSP1) repeat superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IMP
 biological_processGO:0033564 anterior/posterior axon guidance IEA
 biological_processGO:0038007 netrin-activated signaling pathway IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IMP
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0005042 netrin receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Netrin-1 signaling
Netrin mediated repulsion signals
via Dependence Receptors in the absence of ligand


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000065320 NTN1 / O95631 / netrin 1  / complex / reaction
 ENSG00000187323 DCC / P43146 / DCC netrin 1 receptor  / complex / reaction
 ENSG00000164305 CASP3 / P42574 / caspase 3  / reaction
 ENSG00000135439 AGAP2 / Q99490 / ArfGAP with GTPase domain, ankyrin repeat and PH domain 2  / reaction / complex
 ENSG00000196730 DAPK1 / P53355 / death associated protein kinase 1  / complex / reaction






 

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