ENSG00000196730


Homo sapiens

Features
Gene ID: ENSG00000196730
  
Biological name :DAPK1
  
Synonyms : DAPK1 / death associated protein kinase 1 / P53355
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: 1
Band: q21.33
Gene start: 87497228
Gene end: 87708633
  
Corresponding Affymetrix probe sets: 203139_at (Human Genome U133 Plus 2.0 Array)   211214_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000484267
Ensembl peptide - ENSP00000418885
Ensembl peptide - ENSP00000419026
Ensembl peptide - ENSP00000350785
Ensembl peptide - ENSP00000386135
Ensembl peptide - ENSP00000417076
Ensembl peptide - ENSP00000417746
NCBI entrez gene - 1612     See in Manteia.
OMIM - 600831
RefSeq - XM_005251757
RefSeq - NM_001288729
RefSeq - NM_001288730
RefSeq - NM_001288731
RefSeq - NM_004938
RefSeq Peptide - NP_001275658
RefSeq Peptide - NP_001275659
RefSeq Peptide - NP_001275660
RefSeq Peptide - NP_004929
swissprot - P53355
swissprot - F8WCQ3
Ensembl - ENSG00000196730
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dapk1ENSDARG00000060093Danio rerio
 DAPK1ENSGALG00000012608Gallus gallus
 Dapk1ENSMUSG00000021559Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DAPK3 / O43293 / death associated protein kinase 3ENSG0000016765719
SPEG / Q15772 / SPEG complex locusENSG0000007219516
DAPK2 / Q9UIK4 / death associated protein kinase 2ENSG0000003566416
MYLK / Q15746 / myosin light chain kinaseENSG0000006553412
O94768 / STK17B / serine/threonine kinase 17bENSG0000008132010
MYLK4 / Q86YV6 / myosin light chain kinase family member 4ENSG000001459499
Q9UEE5 / STK17A / serine/threonine kinase 17aENSG000001645439
MYLK3 / Q32MK0 / myosin light chain kinase 3ENSG000001407959
MYLK2 / Q9H1R3 / myosin light chain kinase 2ENSG000001013069


Protein motifs (from Interpro)
Interpro ID Name
 IPR000488  Death domain
 IPR000719  Protein kinase domain
 IPR002110  Ankyrin repeat
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011029  Death-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020676  Death-associated protein kinase 1
 IPR020683  Ankyrin repeat-containing domain
 IPR020859  Roc domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006468 protein phosphorylation TAS
 biological_processGO:0006915 apoptotic process IGI
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008625 extrinsic apoptotic signaling pathway via death domain receptors IEA
 biological_processGO:0010506 regulation of autophagy TAS
 biological_processGO:0010508 positive regulation of autophagy IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0017148 negative regulation of translation IDA
 biological_processGO:0035556 intracellular signal transduction IDA
 biological_processGO:0042981 regulation of apoptotic process TAS
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0046777 protein autophosphorylation TAS
 biological_processGO:0071346 cellular response to interferon-gamma IDA
 biological_processGO:0071447 cellular response to hydroperoxide IMP
 biological_processGO:0097190 apoptotic signaling pathway IMP
 biological_processGO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
 biological_processGO:2000310 regulation of NMDA receptor activity ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0015629 actin cytoskeleton IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0004683 calmodulin-dependent protein kinase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0005524 ATP binding IDA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017075 syntaxin-1 binding IPI
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
via Dependence Receptors in the absence of ligand


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000107731 UNC5B / Q8IZJ1 / unc-5 netrin receptor B  / reaction / complex






 

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